Abstract: A catheter assembly includes a catheter body having a catheter lumen. A manifold assembly is coupled with a proximal catheter portion. A manifold lumen extends through the manifold assembly, and the manifold lumen includes an assembly cavity extending around the proximal catheter portion. A fluid jet loop is coupled with a high pressure tube at a distal catheter portion. The catheter assembly further includes a tapered loop guide surface.

Abstract: Fluid infusion systems and fluid couplings are described herein. The infusion systems may include one or more fluid couplings used to make fluidic connection between a supply line and delivery tubing. The fluid couplings separate the functions of providing a seal around a delivery tube and retaining the delivery tube within the fluid coupling. The seal provided around the delivery tube prevents leakage around an exterior surface of a delivery tube such that fluid passing through the coupling must pass through the delivery tube rather than leak around the delivery tube. The structure used to retain the delivery tube in the fluid coupling prevents ejection of the delivery tube from the coupling due to the fluid pressures present in the coupling. The separate functions are performed by different structures within the fluid couplings.

Abstract: A catheter assembly includes a catheter body having a catheter lumen. A manifold assembly is coupled with a proximal catheter portion. A manifold lumen extends through the manifold assembly, and the manifold lumen includes an assembly cavity extending around the proximal catheter portion. A fluid jet loop is coupled with a high pressure tube at a distal catheter portion. The catheter assembly further includes a tapered loop guide surface.

Abstract: Thrombectomy catheters having at least one outflow orifice and one or more inflow orifices, systems including the thrombectomy catheters, and methods of using the thrombectomy catheters are described herein. The thrombectomy catheters described herein may include one or more of the protective features that may limit potential hazards to vessel walls in which the thrombectomy catheters are used.

Abstract: Fluid infusion systems and fluid couplings are described herein. The infusion systems may include one or more fluid couplings used to make fluidic connection between a supply line and delivery tubing. The fluid couplings separate the functions of providing a seal around a delivery tube and retaining the delivery tube within the fluid coupling. The seal provided around the delivery tube prevents leakage around an exterior surface of a delivery tube such that fluid passing through the coupling must pass through the delivery tube rather than leak around the delivery tube. The structure used to retain the delivery tube in the fluid coupling prevents ejection of the delivery tube from the coupling due to the fluid pressures present in the coupling. The separate functions are performed by different structures within the fluid couplings.

Abstract: A catheter including a catheter body having a catheter lumen is disclosed. A manifold assembly is coupled with a proximal catheter portion. A manifold lumen extends through the manifold assembly and includes an assembly cavity extending around the proximal catheter portion. A fluid jet loop including fluid jet orfices along a tapered loop guide surface is coupled with a distal catheter portion. The catheter further includes a composite guide having a proximal guide insert and a distal guide. The proximal guide insert is positioned within the assembly cavity and includes a guide insert surface flush with a catheter body interior wall. The distal guide includes a tapered loop guide surface, and an intermediate guide surface of the catheter lumen is flushly engaged with a leading edge of the tapered loop guide surface, the distal guide continuously tapering inwardly and distally along the tapered loop guide surface.

Abstract: A catheter assembly includes a catheter body having a catheter lumen. A manifold assembly is coupled with a proximal catheter portion. A manifold lumen extends through the manifold assembly, and the manifold lumen includes an assembly cavity extending around the proximal catheter portion. A fluid jet loop is coupled with a high pressure tube at a distal catheter portion. The catheter assembly further includes a composite guide having first and second guide portions. The first guide portion includes a proximal guide insert near the proximal catheter portion, the proximal guide insert is positioned within the assembly cavity, and includes a guide insert surface flush with a catheter body interior wall. The second guide portion includes a distal guide near the distal catheter portion including a tapered loop guide surface and an intermediate guide surface of the catheter lumen flushly engaged with a leading edge of the tapered loop guide surface.