Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4A, R4b, and R5, are as defined herein, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of CLL.

Abstract: The present disclosure provides systems and methods for managing investments. In some aspects, an investment management system comprising at least one processor configured to receive a selection from one or more users relating to interest from the one or more users in an investment opportunity, wherein interest is in the form of a vote, determine if an aggregate of the selections from the one or more users relating to the interest in the investment opportunity reaches a threshold amount of interest, present, if the threshold amount of interest has been met, information relating to the investment opportunity, and receive a selection from the one or more users relating to a financial commitment from the one or more users in the investment opportunity.

Abstract: The concepts, systems and methods described herein are directed towards real time carrier phase monitoring and platform attitude solutions on a moving platform. In an embodiment, highly accurate platform attitude and monitored carrier phases can be determined in a single step and use data screening, error bounds inflation and statistical tests to ensure both inputs and outputs of an attitude solution are self-consistent. The method includes determining a carrier phase error level for each of the satellite-receiver tracks, identifying the satellite-receiver tracks having the carrier phase error level greater than or equal to a carrier phase error threshold, generating an attitude correction using the received data from the one or more satellite-receiver tracks having the carrier phase error level less than the carrier phase error threshold and determining a convergence state of the attitude correction. The carrier phase monitoring may be activated or dis-activated based on the convergence level.

Abstract: A computerized system performs automated schedule optimization. In particular, the system solves the problem of determining the range of advertisement placement prices that a seller can select from, while still satisfying all of the constraints on the buyers' orders. The system generates such a range of prices automatically based on a variety of data. As a result, the system helps the seller to maximize the prices of the potential placements that can satisfy a set of orders from buyers.

Abstract: A system draws an inference about the audience being targeted by the buyer of an advertisement placement opportunity by correlating the order for the advertisement placement opportunity with characteristics of the audience associated with the television program in which the advertisement placement opportunity is embedded. Sellers of advertisement placement opportunities may use the inferred target audience information to appropriately price their advertising inventories and to fulfill orders more effectively.

Abstract: A computer system uses data about delivery of particular content to users via multiple technology platforms. For example, the computer system may track delivery of particular content to an audience via television in order to enable the same or similar content to be delivered to the same or similar audience via a digital medium (e.g., the web), and vice versa. The computer enables the provider of the content (e.g., advertisement) to benefit from exposure data in one medium or technology platform—namely television or digital—when targeting content at viewers in the other medium or technology platform.

Abstract: The concepts, systems and methods described herein are directed towards real time carrier phase monitoring and platform attitude solutions on a moving platform. In an embodiment, highly accurate platform attitude and monitored carrier phases can be determined in a single step and use data screening, error bounds inflation and statistical tests to ensure both inputs and outputs of an attitude solution are self-consistent. The method includes determining a carrier phase error level for each of the satellite-receiver tracks, identifying the satellite-receiver tracks having the carrier phase error level greater than or equal to a carrier phase error threshold, generating an attitude correction using the received data from the one or more satellite-receiver tracks having the carrier phase error level less than the carrier phase error threshold and determining a convergence state of the attitude correction. The carrier phase monitoring may be activated or dis-activated based on the convergence level.

Abstract: A computer system uses data about delivery of particular content to users via multiple technology platforms. For example, the computer system may track delivery of particular content to an audience via television in order to enable the same or similar content to be delivered to the same or similar audience via a digital medium (e.g., the web), and vice versa. The computer enables the provider of the content (e.g., advertisement) to benefit from exposure data in one medium or technology platform—namely television or digital—when targeting content at viewers in the other medium or technology platform.

Abstract: A computer system provides a virtual marketplace in which an advertising opportunity (such as a television advertising opportunity) is expressed in terms of an audience model representing an audience associated with the advertising opportunity. The computer system provides potential buyers of a particular advertising opportunity with information about the audience model associated with that advertising opportunity. The computer system sells advertising opportunities to buyers using any of a variety of transaction semantics. A buyer who purchases a particular advertising opportunity purchases the opportunity to present an advertisement to an audience represented by the audience model associated with the purchased advertising opportunity.