Abstract: An analyte monitoring sensor configured for in vivo measurement of at least one analyte is provided, the sensor comprising a substrate having a substrate surface, an aptamer protective layer encapsulating at least a portion of the substrate surface, the aptamer protective layer permeable to the at least one analyte, one or more aptamer conjugates associated with at least a portion of the substrate surface and positioned between the aptamer protective layer and the substrate for obtaining measurements related to the at least one analyte in vivo. Methods of extending in vivo performance of the analyte monitoring sensor are also described.

Abstract: Techniques for data analysis and user guidance are provided. One or more current measurements of one or more current analyte levels for the user are received from a sensor. A pattern is generated based on the one or more current measurements and the one or more past measurements. A first alignment with a first user target is then determined based on the pattern, where the first user target relates to one or more of a mental state or physical state of the user. A first result is output to the user, based on the determined first alignment.

Abstract: Techniques for data analysis and user guidance are provided. One or more current measurements of one or more current analyte levels for the user are received from a sensor. A pattern is generated based on the one or more current measurements and the one or more past measurements. A first alignment with a first user target is then determined based on the pattern, where the first user target relates to one or more of a mental state or physical state of the user. A first result is output to the user, based on the determined first alignment.

Abstract: Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Abstract: Certain aspects of the present disclosure relate to methods and systems for generating and utilizing analyte measurements. In certain aspects, a monitoring system comprises a continuous analyte sensor configured generate analyte measurements associated with analyte levels of a patient and a sensor electronics module coupled to the continuous analyte sensor and configured to receive and process the analyte measurements.

Abstract: Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

Abstract: An analyte sensor system may include a first communication circuit configured to transmit a wireless signal in a first communication mode and a second communication mode, and a processor, wherein the processor determines whether a first condition is satisfied, the first condition relating to the sensor signal or to communication by the first communication circuit, and shifts the system to a second communication mode responsive to the first condition being satisfied.

Abstract: Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

Abstract: Techniques for data analysis and user guidance are provided. One or more current measurements of one or more current analyte levels for the user are received from a sensor. A pattern is generated based on the one or more current measurements and the one or more past measurements. A first alignment with a first user target is then determined based on the pattern, where the first user target relates to one or more of a mental state or physical state of the user. A first result is output to the user, based on the determined first alignment.

Abstract: A suture locking device includes a carrier member, a locking assembly, a suture path, and an actuator assembly. The locking assembly includes a first locking member having an outer surface portion, and a second locking member having an inner surface portion. The suture path is receptive of a suture and defined at least partially through the first locking member, between the outer and inner surface portions, and at least partially through the carrier member. The actuator assembly is operable to move the first and second locking members together to lock the suture relative to the lock assembly.

Abstract: A suture locking device includes a suture locking assembly, a suture cutting member, and an actuator assembly. The actuator assembly includes a first actuator operable longitudinally to lock the suture with the suture locking assembly, and a second actuator operable laterally to concurrently cut the suture with the suture cutting member and disconnect the suture locking assembly from the suture locking device.

Abstract: A vascular closure system includes a body portion, an anchor, a suture carrying portion, and a plurality of needles. The body portion has a distal end surface. The anchor is positionable through a vessel puncture in a vessel wall of a vessel. The anchor defines a vessel contact surface, wherein withdrawal of the anchor captures a portion of the vessel wall between the vessel contact surface and the distal end surface. The suture carrying portion is positionable through the vessel puncture and carries at least one suture member. The plurality of needles extend through the portion of the vessel wall adjacent to the vessel puncture and are configured to connect to the at least one suture member. Withdrawal of the plurality of needles through the portion of the vessel wall positions the at least one suture member through the portion of the vessel wall.

Abstract: A vascular closure system includes a body portion, an anchor, a suture carrying portion, and a plurality of needles. The body portion has a distal end surface. The anchor is positionable through a vessel puncture in a vessel wall of a vessel. The anchor defines a vessel contact surface, wherein withdrawal of the anchor captures a portion of the vessel wall between the vessel contact surface and the distal end surface. The suture carrying portion is positionable through the vessel puncture and carries at least one suture member. The plurality of needles extend through the portion of the vessel wall adjacent to the vessel puncture and are configured to connect to the at least one suture member. Withdrawal of the plurality of needles through the portion of the vessel wall positions the at least one suture member through the portion of the vessel wall.

Abstract: A suture locking device includes a carrier member, a locking assembly, a suture path, and an actuator assembly. The locking assembly includes a first locking member having an outer surface portion, and a second locking member having an inner surface portion. The suture path is receptive of a suture and defined at least partially through the first locking member, between the outer and inner surface portions, and at least partially through the carrier member. The actuator assembly is operable to move the first and second locking members together to lock the suture relative to the lock assembly.

Abstract: A suture locking device includes a suture locking assembly, a suture cutting member, and an actuator assembly. The actuator assembly includes a first actuator operable longitudinally to lock the suture with the suture locking assembly, and a second actuator operable laterally to concurrently cut the suture with the suture cutting member and disconnect the suture locking assembly from the suture locking device.

Abstract: An adjustable-backset deadbolt lock with a dual-adjustment capability including a simple push-and-twist operation to adjust the relief of the outer casing, as well as a second adjustment capability for adjusting the deadbolt travel. The deadbolt lock generally comprises a latch case defined by opposing walls having an aperture there through, and a guide tab projecting forwardly from the latch case. An annular frontal casing is inserted onto the latch case and receives the guide tab in a track. The frontal casing remains rotatable on the latch case, the track engaging the guide tab during rotation to extend or retract the frontal casing. The track includes two stop positions so that the frontal casing may be adjusted by an indexed push-and-twist adjustment between two positions relative to the latch case as indexed by the stop positions. The lock also includes a deadbolt with adjustable travel via a two-part bolt cam that is turned to extend/retract the bolt extension and deadbolt.