Abstract: The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.

Abstract: A coupling for interfacing a heat source to a heat sink for dissipating heat from the heat source includes a first portion and a second portion. The first portion defines a surface that defines a plurality of spaced apart voids that extend into the first portion. The second portion has an outside surface that complements the surface of the first portion. The second portion is capable of repeated mate and de-mate cycles from the first portion. A gel is disposed on the interior surface of the cavity. In operation, insertion of the second portion within the cavity causes a portion of the gel to displace into openings at first ends of the voids. The gel returns to an original shape when the second portion is removed from the cavity.

Abstract: A cable for coupling a base unit to a remote unit for communicating signals between the base unit to the remote unit includes one or more electrical conductors for communicating electrical signals between the base unit and the remote unit. The cable also includes one or more optical fibers for communicating optical signals between the base unit and the remote unit. An outside jacket is formed around the one or more electrical conductors and that one or more optical fibers.

Abstract: Optical probes may be used to capture images of a subject. An optical probe may include an optical reflector, an optical waveguide, and an electric motor. A rotor of the electric motor is mechanically coupled with the optical reflector to rotate the optical reflector in response to an input electric current. The optical waveguide is optically coupled with the optical reflector. The optical waveguide may output light to the optical reflector which directs the light to the subject. Light may then reflect back from the subject to the optical reflector which directs the reflected light from the subject to the optical waveguide.

Abstract: A diagnostic system includes a remote unit configured to gather information and a base unit configured to process the gathered information. A cable couples the remote unit to the base unit and is configured to carry the information. The cable includes one or more electrical conductors for communicating electrical signals between the base unit and the remote unit. The cable also includes one or more optical fibers over which the gathered information is communicated. An outside sleeve is formed around the one or more electrical conductors and the one or more optical fibers.