Patents by Inventor Jason McClure

Jason McClure has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11131670
    Abstract: A device for determining presence or absence of infection due to an infectious agent is described. The device comprises a sample receiving zone configured to receive a liquid sample from a subject suspected of having an infection due to an infectious agent, the sample receiving zone positioned to distribute the sample along a first fluid flow path to a first label zone and along a second fluid flow path to a second label zone. Test lines in each fluid flow path capture a mobile detectable species as an indicator of presence or absence of the infectious agent. The device also comprises a reference line positioned in the one of the fluid flow paths. The bidirectional fluid flow paths emanate from a common sample zone and provide an efficient approach to detection and differentiate two species as indicators of the same infectious agent or as indicators of two different infectious agents.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: September 28, 2021
    Assignee: Quidel Corporation
    Inventors: Robert Reed, Irene Sinn, Robert Weiller, Jason McClure
  • Publication number: 20210188971
    Abstract: Antibody fusions comprising any antibody or fragment thereof, operably linked, and expressed as a fusion with a label of interest are provided. Plasmids, vectors, host cells, methods, and kits related to the described antibody fusions are also provided. The antibody fusions are useful at least in the diagnostic and reagent setting.
    Type: Application
    Filed: December 18, 2020
    Publication date: June 24, 2021
    Inventors: Jason J. Sun, Richard L. Egan, Jason McClure, Werner Kroll
  • Publication number: 20200292539
    Abstract: A system including a sample receptacle configured to receive a test sample and a test strip coupled to the sample receptacle is provided. The test strip configured to generate a signal based on a concentration of a target analyte in the test sample. The system also includes a detector to generate a transduced signal based on the signal and a computer to receive a transduced signal. The computer further determines the concentration of the target analyte in the test sample. For this, the computer retrieves the transduced signal from the detector at multiple time points to determine a signal rate based on a signal value for the time points, and to determine the concentration of the target analyte based on the signal rate and a model. A method and a non-transitory, computer-readable medium storing instructions to use the above system are also provided.
    Type: Application
    Filed: March 12, 2020
    Publication date: September 17, 2020
    Inventors: Peter Yan-Guo REN, Stewart HOELSCHER, Cristian ALBERTO, Stephanie PINEDO, Jason MCCLURE, Dipesh Jaiswal
  • Publication number: 20200116720
    Abstract: An enzymatic extraction agent, as well as methods, compositions and kits for detecting Group A streptococcus in a biological sample, which involve the enzymatic agent, are described.
    Type: Application
    Filed: October 11, 2019
    Publication date: April 16, 2020
    Inventors: Peter Yan-Guo Ren, Stewart Hoelscher, Cristian Alberto, Stephanie Pinedo, Jason McClure, Hyunjin Kim
  • Publication number: 20200062832
    Abstract: Embodiments of the present disclosure relate to chimeric antibodies which specifically bind to Borrelia decorin-binding protein A (DbpA) antigens and compositions or kits comprising such antibodies. The disclosure further relates to use of such antibodies in the detection of Borrelia sp. in samples, e.g., biological samples such as human blood and/or tissues of deer, ticks and other carriers of Borrelia. Embodiments of the disclosure further relate to diagnosis and/or therapy of Lyme disease using the chimeric antibodies and/or compositions containing the chimeric antibodies.
    Type: Application
    Filed: August 20, 2019
    Publication date: February 27, 2020
    Inventors: Jason J. SUN, Jason McCLURE
  • Publication number: 20190094221
    Abstract: Methods, compositions and kits for detecting Group A streptococcus in a biological sample are described. More particularly, the present disclosure provides an immunoassay in which the specificity of detection of Group A streptococcus is enhanced by addition of N-acetyl-D-glucosamine. These methods, compositions and kits are useful in convenient, reliable and early diagnosis of streptococcal infection in a human subject.
    Type: Application
    Filed: November 28, 2018
    Publication date: March 28, 2019
    Inventors: Peter Yan-Guo REN, Jason MCCLURE, Kevin S. RICHARDSON
  • Patent number: 10168329
    Abstract: Methods, compositions and kits for detecting Group A streptococcus in a biological sample are described. More particularly, the present disclosure provides an immunoassay in which the specificity of detection of Group A streptococcus is enhanced by addition of N-acetyl-D-glucosamine. These methods, compositions and kits are useful in convenient, reliable and early diagnosis of streptococcal infection in a human subject.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: January 1, 2019
    Assignee: Quidel Corporation
    Inventors: Peter Yan-Guo Ren, Jason McClure, Kevin S. Richardson
  • Publication number: 20180229232
    Abstract: A substrate structured to define thereon a fluid flow channel and/or a fluid control feature is described. The substrate may additionally comprise a capture zone and/or a test zone, for use as a test strip for determining presence or absence of an analyte of interest, such as an infectious agent or a biomarker. Reagents are deposited in the capture zone and/or test zone as an array of drops.
    Type: Application
    Filed: February 9, 2018
    Publication date: August 16, 2018
    Inventors: Samantha Chang, Jason McClure, Robert Reed, Irene Sinn Blandy, Robert Weiller, Christian Bobritchi
  • Publication number: 20170059566
    Abstract: A device for determining presence or absence of infection due to an infectious agent is described. The device comprises a sample receiving zone configured to receive a liquid sample from a subject suspected of having an infection due to an infectious agent, the sample receiving zone positioned to distribute the sample along a first fluid flow path to a first label zone and along a second fluid flow path to a second label zone. Test lines in each fluid flow path capture a mobile detectable species as an indicator of presence or absence of the infectious agent. The device also comprises a reference line positioned in the one of the fluid flow paths. The bidirectional fluid flow paths emanate from a common sample zone and provide an efficient approach to detection and differentiate two species as indicators of the same infectious agent or as indicators of two different infectious agents.
    Type: Application
    Filed: August 25, 2016
    Publication date: March 2, 2017
    Inventors: Robert Reed, Irene Sinn, Robert Weiller, Jason McClure
  • Patent number: 9024945
    Abstract: Embodiments include methods that may be used to optically obtain the precise three-dimensional location of multiple objects from one or more two dimensional images. An optical point spread function having a transverse shape which varies with axial distance may be implemented to obtain depth information. The transverse variation in the PSF with depth may be produced using a cylindrical lens. The objects may be imaged by a focal plane array detector. One or more 2D images may be used to find the 3D location of the objects using sparse signal reconstruction methods.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: May 5, 2015
    Assignee: Roper Scientific, Inc.
    Inventor: Jason McClure
  • Publication number: 20140192042
    Abstract: Embodiments include methods that may be used to optically obtain the precise three-dimensional location of multiple objects from one or more two dimensional images. An optical point spread function having a transverse shape which varies with axial distance may be implemented to obtain depth information. The transverse variation in the PSF with depth may be produced using a cylindrical lens. The objects may be imaged by a focal plane array detector. One or more 2D images may be used to find the 3D location of the objects using sparse signal reconstruction methods.
    Type: Application
    Filed: January 4, 2013
    Publication date: July 10, 2014
    Inventor: Jason McClure
  • Patent number: 8773659
    Abstract: An apparatus and method are disclosed for producing spectrographic images free of SI, SII, and SIII field aberrations. The apparatus includes a focusing element placed at a distance from a dispersing element equal to the radius of curvature of the focusing element. The apparatus further includes at least one correcting plate for adding or subtracting abberations.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: July 8, 2014
    Assignee: Roper Scientific Inc.
    Inventor: Jason McClure
  • Publication number: 20130196337
    Abstract: Methods, compositions and kits for detecting Group A streptococcus in a biological sample are described. More particularly, the present disclosure provides an immunoassay in which the specificity of detection of Group A streptococcus is enhanced by addition of N-acetyl-D-glucosamine. These methods, compositions and kits are useful in convenient, reliable and early diagnosis of streptococcal infection in a human subject.
    Type: Application
    Filed: July 31, 2012
    Publication date: August 1, 2013
    Applicant: Quidel Corporation
    Inventors: Peter Yan-Guo Ren, Jason McClure, Kevin S. Richardson
  • Publication number: 20130182250
    Abstract: An apparatus and method are disclosed for producing spectrographic images free of SI, SII, and SIII field aberrations. The apparatus includes a focusing element placed at a distance from a dispersing element equal to the radius of curvature of the focusing element. The apparatus further includes at least one correcting plate for adding or subtracting abberations.
    Type: Application
    Filed: January 13, 2012
    Publication date: July 18, 2013
    Applicant: ROPER SCIENTIFIC, INC.
    Inventor: Jason McClure
  • Patent number: 8436423
    Abstract: A backside-illuminated image sensor is disclosed having improved quantum efficiency (QE) in the near infrared wavelengths (NIR: 750-1100 nm) with minimal optical interference fringes produced by multiple reflected rays within the photosensitive Si region of the sensor, which may be a charge-coupled device, a complementary metal oxide sensor or an electron-multiplication sensor. The invention comprises a fringe suppression layer applied to the backside surface of the photosensitive Si region of a detector (Si substrate) whereby the fringe suppression layer functions in concert with the Si substrate to reduce the occurrence of interference fringes in the NIR while maintaining a high QE over a broad range of wavelengths (300-1100 nm). The combination of a fringe suppression layer applied to a Si substrate provides a new class of back illuminated solid state detectors for imaging.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: May 7, 2013
    Assignee: Roper Scientific, Inc.
    Inventors: William Edward Asher, Michael Alan Case, Jason McClure
  • Patent number: 7999933
    Abstract: Disclosed is a method for calibrating optical spectrographs, and in particular optical spectrographs having focal plane array detectors. The method comprises the steps of detecting a spectrum of a known source, referencing a table of known spectral wavelengths and relative intensities, and deriving a spectrograph model based on the spectrograph's physical properties to approximate the observed spectrum, wherein non-linear optimization techniques refine the theoretical model parameters, thereby minimizing the residual difference between observed and calculated spectral intensities in an iterative process producing a set of physical model parameters that best describe the modeling spectrograph for calibration of subsequent spectral acquisitions.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: August 16, 2011
    Assignee: Princeton Instruments
    Inventor: Jason McClure
  • Publication number: 20110175185
    Abstract: A backside-illuminated image sensor is disclosed having improved quantum efficiency (QE) in the near infrared wavelengths (NIR: 750-1100 nm) with minimal optical interference fringes produced by multiple reflected rays within the photosensitive Si region of the sensor, which may be a charge-coupled device, a complementary metal oxide sensor or an electron-multiplication sensor. The invention comprises a fringe suppression layer applied to the backside surface of the photosensitive Si region of a detector (Si substrate) whereby the fringe suppression layer functions in concert with the Si substrate to reduce the occurrence of interference fringes in the NIR while maintaining a high QE over a broad range of wavelengths (300-1100 nm). The combination of a fringe suppression layer applied to a Si substrate provides a new class of back illuminated solid state detectors for imaging.
    Type: Application
    Filed: January 20, 2011
    Publication date: July 21, 2011
    Applicant: ROPER SCIENTIFIC, INC.
    Inventors: William Edward Asher, Michael Alan Case, Jason McClure
  • Publication number: 20110037975
    Abstract: Disclosed is a method for calibrating optical spectrographs, and in particular optical spectrographs having focal plane array detectors. The method comprises the steps of detecting a spectrum of a known source, referencing a table of known spectral wavelengths and relative intensities, and deriving a spectrograph model based on the spectrograph's physical properties to approximate the observed spectrum, wherein non-linear optimization techniques refine the theoretical model parameters, thereby minimizing the residual difference between observed and calculated spectral intensities in an iterative process producing a set of physical model parameters that best describe the modeling spectrograph for calibration of subsequent spectral acquisitions.
    Type: Application
    Filed: August 14, 2009
    Publication date: February 17, 2011
    Applicant: PRINCETON INSTRUMENTS
    Inventor: Jason McClure
  • Publication number: 20060086624
    Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
    Type: Application
    Filed: November 16, 2005
    Publication date: April 27, 2006
    Inventors: Mark Tapsak, Rathbun Rhodes, Mark Shults, Jason McClure
  • Publication number: 20060068208
    Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
    Type: Application
    Filed: November 16, 2005
    Publication date: March 30, 2006
    Inventors: Mark Tapsak, Rathbun Rhodes, Mark Shults, Jason McClure