Patents by Inventor Jason Michael Romero

Jason Michael Romero has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for selective expansion of delta-3 gamma delta T-cell populations and compositions thereof
    Patent number: 12221480
    Abstract: The present application is directed to agents that bind an epitope specific to a ?3 ?? TCR. Such agents can be, but are not limited to, an antibody or fragment thereof. Also described herein are methods for using the agents, e.g., to expand or selectively expand ?3 ?? T cells. Also described herein are methods of using expanded ?3 ?? T cells for treatment of a subject in need thereof.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: February 11, 2025
    Inventors: Aya Jakobovits, Daulet Kadyl Satpayev, Orit Foord, Yifeng Frank Jing, Hui Shao, Jason Michael Romero, Mary Michael Brody, Matthew Ian Hoopes
  • METHODS FOR SELECTIVE EXPANSION OF DELTA-3 GAMMA DELTA T-CELL POPULATIONS AND COMPOSITIONS THEREOF
    Publication number: 20230257462
    Abstract: The present application is directed to agents that bind an epitope specific to a ?3 ?? TCR. Such agents can be, but are not limited to, an antibody or fragment thereof. Also described herein are methods for using the agents, e.g., to expand or selectively expand ?3 ?? T cells. Also described herein are methods of using expanded ?3 ?? T cells for treatment of a subject in need thereof.
    Type: Application
    Filed: November 15, 2018
    Publication date: August 17, 2023
    Inventors: Aya Jakobovits, Daulet Kadyl Satpayev, Orit Foord, Yifeng Frank Jing, Hui Shao, Jason Michael Romero, Mary Michael Brodey, Matthew Ian Hoopes
  • COMPOSITIONS AND METHODS REGARDING ENGINEERED AND NON-ENGINEERED GAMMA DELTA T-CELLS FOR TREATMENT OF HEMATOLOGICAL TUMORS
    Publication number: 20210388100
    Abstract: Aspects of the invention include compositions and methods for treatment of hematological tumors with engineered or non-engineered ??-T cells. In some embodiments, the ??-T cells comprise a chimeric antigen receptor (CAR) construct. The CAR construct can contain an anti-CD20 binding domain or anti-B cell maturation antigen (BCMA) binding domain, a CD8 hinge and transmembrane domain, a costimulatory domain, a CD3 ? signalling domain, a combination thereof, or all thereof. The CAR construct can contain a domain encoding for a secreted common gamma chain cytokine such as a sIL 15 domain.
    Type: Application
    Filed: October 1, 2019
    Publication date: December 16, 2021
    Inventors: Daulet Kadyl Satpayev, Marissa Ann Herrman, Jason Michael Romero, Yifeng Frank Jing, Zili An, Aya Jakobovits
  • COMPOSITIONS AND METHODS REGARDING ENGINEERED AND NON-ENGINEERED GAMMA DELTA T-CELLS FOR TREATMENT OF SOLID TUMORS
    Publication number: 20210388109
    Abstract: Aspects of the invention include compositions and methods for treatment of solid tumors with engineered or non-engineered ??-T cells. In some embodiments, the ??-T cells comprise a chimeric antigen receptor (CAR) construct. The CAR construct can contain an anti-TryD binding domain, a CD8? hinge and transmembrane domain, a costimulatory domain, a 003? signalling domain, a combination thereof, or all thereof. The CAR construct can contain an anti-GPC3 binding domain, a CD8? hinge and transmembrane domain, a costimulatmy domain, a CD3? signalling domain, a combination thereof, or all thereof. The CAR construct can contain a domain encoding for a secreted common gamma chain cytokine such as a sIL 15 domain.
    Type: Application
    Filed: October 1, 2019
    Publication date: December 16, 2021
    Inventors: Daulet Kadyl Satpayev, Marissa Ann Herrman, Jason Michael Romero, Yifeng Frank Jing, Zili An, Aya Jakobovits