Abstract: A surgical instrument and method for assessing restoration of the femoral head centre is provided. The instrument comprising: a body having a first connector for attaching the body to a femoral part, and wherein the body defines a plurality of apertures therein, wherein each aperture corresponds to a respective femoral head centre arising from a respective corresponding femoral neck; and a gauge, wherein the gauge includes a pin at a first end and an arm extending transversely from the pin and wherein the pin is receivable in each of the plurality of apertures and the arm bears a scale indicating a distance from the pin. The approach seeks to provide a simple and/or easy to use approach to restoring the native femoral head position during a hip replacement surgical procedure.

Abstract: A cement restrictor inserter instrument (130) comprises an inserter (131) having a handle (132) at a proximal end, a cement restrictor attachment formation (137) at a distal end for releasably attaching a cement restrictor (150), a shaft (136) extending from the proximal end to the distal end and a stop (138) on the shaft and between the proximal end and the distal end; and a body (140) having a shape corresponding to the shape of an orthopaedic prosthetic implant, a spacer (142), a visible depth guide feature (190) and a releasable attachment mechanism by which the body is releasably attachable to the shaft, and wherein the spacer is configured to position the visible depth guide feature at a fixed position relative to the inserter when the spacer abuts the stop corresponding to a target cement restrictor position when the visible depth guide feature is aligned with a feature of a bone of a patient in which the cement restrictor is to be inserted.

Abstract: The invention provides a surgical device for performing a controlled resection of the neck of a femur during a hip replacement procedure. The surgical device comprises a body portion having: a frame comprising an aperture dimension for receipt of a femoral head of the femur to position the body portion with respect to a centre of the femoral head; a resection guide for indicating a position of a resection plane on the femoral neck, and an arm extending between the frame and the resection guide. The body portion includes a linear alignment surface for alignment with a femoral shaft axis of the femur while the frame is mounted on the anterior or posterior aspect of the femoral head.

Abstract: A trial neck for hip surgery and a method of attaching a trial neck to a bone canal preparation instrument. The trial neck includes a body portion having a bore for receiving a proximal end of the bone canal preparation instrument. The trial neck also includes an elongate neck part comprising a pair of arms extending from the body portion. The trial neck further includes a clamping mechanism comprising a live spring formed by the body portion and said pair of arms of the elongate neck part and an actuator, for moving the clamping mechanism between a clamping configuration and a non-clamping configuration. In the clamping configuration, the pair of arms of the elongate neck part are pinched together to cause an inner wall of the bore to urge against the bone canal preparation instrument to retain the proximal end of the bone canal preparation instrument within the bore.

Abstract: The present disclosure relates to a manufacturing system, method and control circuitry for quality assured manufacturing of at least two biopharmaceutical products. The manufacturing system comprises a warehouse facility, a hydration facility, and at least two biopharmaceutical manufacturing facilities, wherein the warehouse facility and hydration facility are comprised in the macro structure. Each biopharmaceutical manufacturing facility is comprised in a respective micro node, and a control facility in the macro structure is configured to control interoperability of the macro structure and the micro nodes by means of a network spine interconnecting the macro structure with each micro node.

Abstract: The invention provides a surgical device for performing a controlled resection of the neck of a femur during a hip replacement procedure. The surgical device comprises a body portion having: a frame comprising an aperture dimension for receipt of a femoral head of the femur to position the body portion with respect to a centre of the femoral head; a resection guide for indicating a position of a resection plane on the femoral neck, and an arm extending between the frame and the resection guide. The body portion includes a linear alignment surface for alignment with a femoral shaft axis of the femur while the frame is mounted on the anterior or posterior aspect of the femoral head.

Abstract: The invention provides a surgical apparatus for performing a controlled resection of the neck of a femur during a hip replacement procedure, the surgical apparatus comprising: a body portion. The body portion comprises a frame that is mountable on a femoral head of the femur to position the body portion with respect to a centre of the femoral head. The body portion also includes a resection guide for indicating a position of a resection plane on the femoral neck, and an arm extending from the frame and including markings for reading off a femoral head offset. The apparatus also includes a connector for mounting the body portion on an intramedullary rod located in an intramedullary canal of the femur, and for slidably receiving the arm. The connector includes a pointer. The femoral head offset is indicated by reading the position of the pointer relative to the markings on the arm.

Abstract: A device for use in orthopaedic surgery. The device includes a metallic central member. The device also includes an outer portion comprising a polymer. The outer portion surrounds the metallic central member. The outer portion has a profiled outer surface for removing bone. A surgical instrument kit including a plurality of differently sized devices of the kind described herein. The device can be a broach or rasp. A method of removing bone during orthopaedic surgery.

Abstract: The present disclosure relates to a manufacturing system, method and control circuitry for quality assured manufacturing of at least two biopharmaceutical products. The manufacturing system comprises a warehouse facility, a hydration facility, and at least two biopharmaceutical manufacturing facilities, wherein the warehouse facility and hydration facility are comprised in the macro structure. Each biopharmaceutical manufacturing facility is comprised in a respective micro node, and a control facility in the macro structure is configured to control interoperability of the macro structure and the micro nodes by means of a network spine interconnecting the macro structure with each micro node.

Abstract: The present disclosure relates to a manufacturing system, method and control circuitry for quality assured manufacturing of at least two biopharmaceutical products. The manufacturing system comprises a warehouse facility, a hydration facility, and at least two biopharmaceutical manufacturing facilities, wherein the warehouse facility and hydration facility are comprised in the macro structure. Each biopharmaceutical manufacturing facility is comprised in a respective micro node, and a control facility in the macro structure is configured to control interoperability of the macro structure and the micro nodes by means of a network spine interconnecting the macro structure with each micro node.

Abstract: The present disclosure relates to a manufacturing system, method and control circuitry for quality assured manufacturing of at least two biopharmaceutical products. The manufacturing system comprises a warehouse facility, a hydration facility, and at least two biopharmaceutical manufacturing facilities, wherein the warehouse facility and hydration facility are comprised in the macro structure. Each biopharmaceutical manufacturing facility is comprised in a respective micro node, and a control facility in the macro structure is configured to control interoperability of the macro structure and the micro nodes by means of a network spine interconnecting the macro structure with each micro node.

Abstract: The present disclosure relates to a manufacturing system, method and control circuitry for quality assured manufacturing of at least two biopharmaceutical products. The manufacturing system comprises a warehouse facility, a hydration facility, and at least two biopharmaceutical manufacturing facilities, wherein the warehouse facility and hydration facility are comprised in the macro structure. Each biopharmaceutical manufacturing facility is comprised in a respective micro node, and a control facility in the macro structure is configured to control interoperability of the macro structure and the micro nodes by means of a network spine interconnecting the macro structure with each micro node.

Abstract: A device for use in orthopaedic surgery. The device includes a metallic central member. The device also includes an outer portion comprising a polymer. The outer portion surrounds the metallic central member. The outer portion has a profiled outer surface for removing bone. A surgical instrument kit including a plurality of differently sized devices of the kind described herein. The device can be a broach or rasp. A method of removing bone during orthopaedic surgery.

Abstract: A device (10) for use in orthopedic surgery includes a metallic central member (30). The device also includes an outer portion (20) comprising a polymer, which can be molded around the metallic central member. The outer portion thus surrounds the metallic central member. The outer portion has a profiled outer surface (40), such as teeth, ribs or ridges for removing bone. Engagement features for resisting relative movement between the metallic central member and the outer portion can comprise ridges, grooves (34, 36) and apertures (32) of the metallic central member, filled with polymer. The device can be a broach or rasp. A surgical instrument kit includes a plurality of differently sized devices of the kind described herein.

Abstract: The present disclosure relates to a manufacturing system, method and control circuitry for quality assured manufacturing of at least two biopharmaceutical products. The manufacturing system (100) comprises a warehouse facility (210), a hydration facility (220), and at least two biopharmaceutical manufacturing facilities, wherein the warehouse facility (210) and hydration facility (220) are comprised in the macro structure (200). Each biopharmaceutical manufacturing facility is comprised in a respective micro node (300), and a control facility (230) in the macro structure (200) is configured to control interoperability of the macro structure (200) and the micro nodes (300) by means of a network spine interconnecting the macro structure (200) with each micro node (300).

Abstract: Microclip appliance formed from a single conductive planar metal sheet includes portions defined along an elongated length including a pin receiver, a solder paddle and a bridge. The pin receiver includes first and second planar rings, and a spring bar extending from a periphery of the first ring to a periphery of the second ring. The solder paddle is comprised of a portion of the conductive metal sheet distal from the pin receiver and the bridge extends from a peripheral portion of the solder paddle to the second ring. Lateral bends are disposed along a length of the conductive planar metal sheet to facilitate the various portions of the microclip.

Abstract: A device (10) for use in orthopaedic surgery includes a metallic central member (30). The device also includes an outer portion (20) comprising a polymer, which can be moulded around the metallic central member. The outer portion thus surrounds the metallic central member. The outer portion has a profiled outer surface (40), such as teeth, ribs or ridges for removing bone. Engagement features for resisting relative movement between the metallic central member and the outer portion can comprise ridges, grooves (34, 36) and apertures (32) of the metallic central member, filled with polymer. The device can be a broach or rasp. A surgical instrument kit includes a plurality of differently sized devices of the kind described herein.

Abstract: The present invention relates to isolated Cpn10 polypeptides possessing an increased affinity for a PRR ligand compared to Ala Cpn10 polypeptide. In a further embodiment, the present invention also relates to modified chaperonin 10 polypeptides, and to nucleic acids encoding the same and to compositions comprising such polypeptides and uses thereof.

Abstract: The invention relates generally to chaperonin 10 N-terminal variants. More specifically, the invention relates to chaperonin 10 N-terminal variants with enhanced immunomodulatory capacity and/or enhanced binding affinity for pathogen-associated molecular patterns (PAMPs) and/or damage-associated molecular patterns (PAMPs).

Abstract: The invention relates generally to chaperonin 10 N-terminal variants. More specifically, the invention relates to chaperonin 10 N-terminal variants with enhanced immunomodulatory capacity and/or enhanced binding affinity for pathogen-associated molecular patterns (PAMPs) and/or damage-associated molecular patterns (DAMPs).