Abstract: A technique for servicing a memory request is disclosed. The technique includes obtaining permissions associated with a source and a destination specified by the memory request, obtaining a first set of address translations for the memory request, and executing operations for a first request, using the first set of address translations.

Abstract: One variation of a system includes a bogie including: a chassis; a first set of latches configured to transiently engage a first subset of engagement features, in a first array of engagement features on a left rail and in a second array of engagement features on a right rail of the trailer, to retain the bogie below a floor of the trailer; a driven axle suspended from the chassis; and a motor coupled to the driven axle and configured to output torque to the driven axle and regeneratively brake the driven axle. The system further includes a battery assembly: including a second set of latches configured to transiently engage a second subset of engagement features, in the first array of engagement features and in the second array of engagement features, to retain the battery assembly adjacent the bogie; and configured to receive electrical energy from the motor.

Abstract: This invention relates to methods and systems for searching. It is particularly applicable to methods of searching which enable efficient identification of compatible portfolios. Embodiments of the invention propose methods of searching which address the huge search space issue associated with identifying compatible portfolios. In particular, embodiments of the invention start their search operations simultaneously from both sides by both trying to form valid portfolios from candidate products until a valid solution is found and trying to find conflicts from the defined compatibility rules until a conflict is found which leads to the conclusion that no valid solution exists. A conclusion from either process will stop the whole searching process which can significantly reduce blind and unnecessary searching in the whole search space.

Abstract: The invention relates generally to systems and devices for material delivery, energy delivery, and/or monitoring electrophysiological activity, and method of use thereof. In particular, the present invention provides devices and systems, and methods of use thereof, configured to deliver therapeutic compositions, to provide electroporation and/or sonoporation to increase therapeutic efficiency, and to monitor electrophysiological activity, for example, before and after treatment.

Abstract: Described here are systems and methods for producing high-resolution three-dimensional (“3D”) relaxation parameter maps by calibrating high-resolution 3D magnetic resonance images. As one example, high-resolution longitudinal relaxation time (“T1”) maps can be generated based on images acquired using a T1-weighted pulse sequence, and as another example high-resolution transverse relaxation time (“T2”) maps can be generated based on images acquired using a T2-weighted pulse sequence. The high-resolution images can be calibrated, for example, using a lower resolution single slice relaxation parameter map. The methods described here utilize high-resolution 3D scans and low-resolution relaxation parameter maps that are commonly available on MRI systems. The calibration is a post-processing step used to create the high-resolution 3D relaxation parameter maps from these two types of scans.

Abstract: At least one location of interest for perpetuation or persistence of arrhythmia or atrial fibrillation is identified by determining a repeatability of electrogram morphologies from electrical recordings within at least one atrium.

Abstract: The invention relates generally to systems and devices for material delivery, energy delivery, and/or monitoring electrophysiological activity, and method of use thereof. In particular, the present invention provides devices and systems, and methods of use thereof, configured to deliver therapeutic compositions, to provide electroporation and/or sonoporation to increase therapeutic efficiency, and to monitor electrophysiological activity, for example, before and after treatment.

Abstract: Described here are systems and methods for producing high-resolution three-dimensional (“3D”) relaxation parameter maps by calibrating high-resolution 3D magnetic resonance images. As one example, high-resolution longitudinal relaxation time (“T1”) maps can be generated based on images acquired using a T1-weighted pulse sequence, and as another example high-resolution transverse relaxation time (“T2”) maps can be generated based on images acquired using a T2-weighted pulse sequence. The high-resolution images can be calibrated, for example, using a lower resolution single slice relaxation parameter map. The methods described here utilize high-resolution 3D scans and low-resolution relaxation parameter maps that are commonly available on MRI systems. The calibration is a post-processing step used to create the high-resolution 3D relaxation parameter maps from these two types of scans.

Abstract: The invention relates generally to systems and devices for material delivery, energy delivery, and/or monitoring electrophysiological activity, and method of use thereof. In particular, the present invention provides devices and systems, and methods of use thereof, configured to deliver therapeutic compositions, to provide electroporation and/or sonoporation to increase therapeutic efficiency, and to monitor electrophysiological activity, for example, before and after treatment.

Abstract: This invention relates to methods and systems for searching. It is particularly applicable to methods of searching which enable efficient identification of compatible portfolios. Embodiments of the invention propose methods of searching which address the huge search space issue associated with identifying compatible portfolios. In particular, embodiments of the invention start their search operations simultaneously from both sides by both trying to form valid portfolios from candidate products until a valid solution is found and trying to find conflicts from the defined compatibility rules until a conflict is found which leads to the conclusion that no valid solution exists. A conclusion from either process will stop the whole searching process which can significantly reduce blind and unnecessary searching in the whole search space.

Abstract: A method of targeting fibrosis or autonomic nerve tissue for ablation in a subject is provided. The method includes performing at least one EGM analysis of a plurality of recorded atrial EGMs for a tissue in a region suspected of having fibrosis or autonomic nerve tissue. With regard to targeting fibrosis for ablation, the method includes determining one or more correlations of at least one AF EGM characteristic to a region having fibrosis from the plurality of recorded atrial EGMs for the tissue and determining whether the tissue contains dense fibrosis that would preclude effective ablation of the analysis region of the tissue. With regard to targeting autonomic nerve for ablation, the method includes determining whether one or more significant changes in EGM characteristics with autonomic blockade exist that would indicate the need to perform ablation of the analysis region of the tissue.

Abstract: A method is provided of analyzing a cardiac electrogram using a computer. In one step, a determination is made as to a plurality of cycle lengths between a plurality of activation peaks of the cardiac electrogram. In another step, a determination is made as to whether a mean of the plurality of cycle lengths meets at least one criteria. The method may be used to iteratively adjust a detection threshold level for detecting atrial fibrillation based on the cardiac electrogram.

Abstract: A method is provided of analyzing a cardiac electrogram using a computer. In one step, a determination is made as to a plurality of cycle lengths between a plurality of activation peaks of the cardiac electrogram. In another step, a determination is made as to whether a mean of the plurality of cycle lengths meets at least one criteria. The method may be used to iteratively adjust a detection threshold level for detecting atrial fibrillation based on the cardiac electrogram.

Abstract: A method is provided of analyzing a cardiac electrogram using a computer. In one step, a determination is made as to a plurality of cycle lengths between a plurality of activation peaks of the cardiac electrogram. In another step, a determination is made as to whether a mean of the plurality of cycle lengths meets at least one criteria. The method may be used to iteratively adjust a detection threshold level for detecting atrial fibrillation based on the cardiac electrogram.

Abstract: At least one location of interest for perpetuation or persistence of arrhythmia or atrial fibrillation is identified by determining a repeatability of electrogram morphologies from electrical recordings within at least one atrium.

Abstract: A method of targeting fibrosis or autonomic nerve tissue for ablation in a subject is described. The method includes at least the following steps. The method includes performing at least one EGM analysis of a plurality of recorded atrial EGMs for a tissue in a region suspected of having fibrosis or autonomic nerve tissue. With regard to targeting fibrosis for ablation, the method includes determining one or more correlations of at least one AF EGM characteristic to a region having fibrosis from the plurality of recorded atrial EGMs for the tissue and determining whether the tissue contains dense fibrosis that would preclude effective ablation of the analysis region of the tissue. With regard to targeting autonomic nerve for ablation, the method includes determining whether one or more significant changes in EGM characteristics with autonomic blockade exist that would indicate the need to perform ablation of the analysis region of the tissue.

Abstract: A method of targeting fibrosis or autonomic nerve tissue for ablation in a subject is provided. The method includes performing at least one EGM analysis of a plurality of recorded atrial EGMs for a tissue in a region suspected of having fibrosis or autonomic nerve tissue. With regard to targeting fibrosis for ablation, the method includes determining one or more correlations of at least one AF EGM characteristic to a region having fibrosis from the plurality of recorded atrial EGMs for the tissue and determining whether the tissue contains dense fibrosis that would preclude effective ablation of the analysis region of the tissue. With regard to targeting autonomic nerve for ablation, the method includes determining whether one or more significant changes in EGM characteristics with autonomic blockade exist that would indicate the need to perform ablation of the analysis region of the tissue.

Abstract: A method is provided of analyzing a cardiac electrogram using a computer. In one step, a determination is made as to a plurality of cycle lengths between a plurality of activation peaks of the cardiac electrogram. In another step, a determination is made as to whether a mean of the plurality of cycle lengths meets at least one criteria. The method may be used to iteratively adjust a detection threshold level for detecting atrial fibrillation based on the cardiac electrogram.

Abstract: A method of targeting fibrosis or autonomic nerve tissue for ablation in a subject is described. The method includes at least the following steps. The method includes performing at least one EGM analysis of a plurality of recorded atrial EGMs for a tissue in a region suspected of having fibrosis or autonomic nerve tissue. With regard to targeting fibrosis for ablation, the method includes determining one or more correlations of at least one AF EGM characteristic to a region having fibrosis from the plurality of recorded atrial EGMs for the tissue and determining whether the tissue contains dense fibrosis that would preclude effective ablation of the analysis region of the tissue. With regard to targeting autonomic nerve for ablation, the method includes determining whether one or more significant changes in EGM characteristics with autonomic blockade exist that would indicate the need to perform ablation of the analysis region of the tissue.

Abstract: The invention relates generally to systems and devices for material delivery, energy delivery, and/or monitoring electrophysiological activity, and method of use thereof. In particular, the present invention provides devices and systems, and methods of use thereof, configured to deliver therapeutic compositions, to provide electroporation and/or sonoporation to increase therapeutic efficiency, and to monitor electrophysiological activity, for example, before and after treatment.