Abstract: The present invention relates to novel c-MYC mRNA translation modulators, composition and methods of preparation thereof, and uses thereof in the treatment of cancer.

Abstract: A system and method of providing real time account information for financial accounts is disclosed. The system includes an event based architecture including an event stream. Financial transaction processing systems publish transaction events to the event stream. A transaction service listening to the event stream detects new transaction events. The transaction service takes action to enrich transaction data. A middleware system reconciles existing transactions and persists transaction records in long term storage. The system can retrieve real time enriched transaction data to calculate account summary information, including current account balances and projected future account balances. The system can also be used to provide real time notifications to customers using enriched transaction data.

Abstract: The present invention relates to novel c-Myc mRNA translation modulators, composition and methods of preparation CA thereof, and uses thereof in the treatment of cancer.

Abstract: Systems and techniques are provided herein to enable an authoritative DNS zone to selectively utilize a forwarding service to resolve domain names that cannot be resolved by the authoritative DNS zone. A forwarder indication may be provided in an authoritative DNS zone configuration file specific to the authoritative DNS zone to indicate whether the forwarding service is active.

Abstract: Apparatus and methods for the detection of proteins in biological fluids such as urine using a label-free assay is described. Specific proteins are detected by their binding to highly specific capture reagents such as SOMAmers that are attached to the surface of a substrate. Changes to these capture reagents and their local environment upon protein binding modify the behavior of color centers (e.g., fluorescence, ionization state, spin state, etc.) embedded in the substrate beneath the bound capture reagents. These changes can be read out, for example, optically or electrically, for an individual color center or as an average response of many color centers.

Abstract: Embodiments include an aircraft comprising a fuselage; a wing connected to the fuselage; and first and second propulsion systems connected to the wing on opposite sides of the fuselage, wherein at least a portion of each of the first and second propulsion systems and at least a portion of the wing are tiltable between a first position in which the aircraft is in a hover mode and a second position in which the aircraft is in a cruise mode, wherein each of the propulsion systems includes pylon and a rotor assembly comprising a plurality of rotor blades.

Abstract: Devices, systems, and methods are provided for indoor localization. A self-driving vehicle may detect a first fiducial marker located at a first location within a building, wherein the first fiducial marker comprises first fiducial marker information associated with the first location. The self-driving vehicle may retrieve the first fiducial marker information from the first fiducial marker. The self-driving vehicle may generate localization information of the self-driving vehicle based on the first fiducial marker information. The self-driving vehicle may utilize the localization information to transition to a second location within the building, wherein the second location comprises a second fiducial marker.

Abstract: Various examples include a substrate pre-aligner system that can align substrates by detecting a fiducial on the substrate, determine an amount of bow in the substrate, and determine other characteristics of the substrate. In one example, by imaging both a 0-degree orientation and after a single 180-degree rotation of the substrate, the pre-aligner of the disclosed subject-matter can determine, for example, a location of the fiducial and bow in the substrate. In other embodiments, multiple cameras are used to capture images of the substrate substantially simultaneously and determine, for example, a location of the fiducial and bow in the substrate. The multiple camera embodiment can also allow a higher throughput of substrates as compared with the 0-degree to 180-degree embodiment. Other systems and methods are also disclosed.

Abstract: Provided herein is a vaccine against RSV. The vaccine comprises an mRNA encoding a stabilised prefusion RSV F protein immunogen linked to a scaffold based on lumazine synthase.

Abstract: Systems, devices, and process described facilitate use of a first user device communicatively coupled to a local area network (LAN) The first user device may include a first hardware processor configured to execute first, non-transient, computer instructions for facilitating a first seamless DVR engine configured to identify a first content. A second user device is also coupled to the LAN. The second user device may include a second hardware processor configured to execute second, non-transient, computer instructions for facilitating a second seamless DVR configured to identify a second content. Each of the seamless DVR engines may be configured to generate a common universal directory identifying the first content and the second content as being available for use by each of the first user device and the second user device. User devices may independently populate the common universal directory. The universal directory may identify a distinct status for the content.

Abstract: Various examples include a system and network to map of substrates within a substrate carrier (e.g., such as silicon wafers within a wafer cassette), and a classification of a state of each substrate, as well as the carrier in which the substrates are placed. In various examples provided herein, an image acquisition system, such as a camera, acquires multiple images of the substrates within the carrier. The image or images are then processed with a deep-convolutional neural-network to classify a state of the substrate relative to a substrate slot including empty slots, occupied slots (e.g., properly loaded slots), double-loaded slots, cross-slotted, and protruded (where a substrate is not fully loaded into a slot).

Abstract: A variety of charge tubes for perforating gun systems including, in one embodiment, a method attaching a charge tube, comprising swaging one or more ends of the charge tube to form at least one swaged end on the charge tube, wherein the charge tube comprises a plurality of charge ports; and coupling the at least one swaged end to a gun system component.

Abstract: A sorbent material may include activated carbon, wherein the activated carbon has been subjected to an impregnation with a nitrogen-containing compound, a calcination, an oxidation, or combinations thereof, wherein the sorbent material includes about 5 wt. % to about 10 wt. % nitrogen and has an iodine number of about 1000 mg/g to about 1500 mg/g. Methods of producing such a sorbent material are also described.

Abstract: The present embodiments relate to establishing secure data communication using an Elliptic-curve Diffie-Hellman ephemeral (ECDHE) key agreement procedure. Devices in a network environment can utilize a key agreement procedure to establish secure communication between multiple application layers in a micro service architecture. Particularly, a tunnel can be established between a mobile device and an encryption service by transmitting key information between the mobile device and the encryption service. This can allow for encryption keys to only be accurately generated by the mobile device and encryption service. Accordingly, intermediary nodes may be unable to decrypt the data, allowing for safe and secure transport of sensitive data.

Abstract: An arc-detection system for detecting an arc during an electrocautery surgical procedure may comprise a camera portion and an image processing controller portion. The camera portion may be sized for minimally invasive penetration into a patient's body. The camera portion may comprise a wide-angle lens having a field of view wider than 45 degrees and wider than a field of view of a conventional endoscopic camera system. The image processing controller portion may be configured to monitor images captured by the camera portion and configured to detect thermal changes to tissue at the surgical site.

Abstract: Provided are computer-implemented systems and methods for a device that includes at least one processor programmed or configured to receive one or more messages from a device in an transmit state, the one or more messages comprising a first message received at a first power level, the first message comprising data associated with a power level at which the first message was transmitted by the transmitting device, and a second messages received at a second power level, the second message comprising data associated with a power level at which the second message was transmitted by the transmitting device. The processor is further configured to determine a heading toward the transmitting device based on the first message and the second message; and output data associated with an indication of the heading toward the transmitting device.

Abstract: Provided are computer-implemented systems and methods for a device that includes at least one processor programmed or configured to receive one or more messages from a device in an transmit state, the one or more messages comprising a first message received at a first power level, the first message comprising data associated with a power level at which the first message was transmitted by the transmitting device, and a second messages received at a second power level, the second message comprising data associated with a power level at which the second message was transmitted by the transmitting device. The processor is further configured to determine a heading toward the transmitting device based on the first message and the second message; and output data associated with an indication of the heading toward the transmitting device.

Abstract: A method of removing organic carbon and other contaminants from a water stream. The method comprises screening large solids from the stream. Pre-oxidation chemicals may then be added. A coagulant is fed into the stream. An activated carbon, preferably formed from lignite, is added by pumping a highly concentrated activated carbon slurry into the stream. The stream, including the activated carbon and coagulant, next flows into a clarifier, where the coagulant will flocculate and enmesh the activated carbon. The activated carbon adsorbs organic carbon and other contaminants, including bacteria, pharmacological agents, and hydrocarbons, as the stream flows through the clarifier. Eventually, the flocculate will agglomerate and settle out in the clarifier, where it, the enmeshed carbon, and the contaminants they contain may be removed. The stream's organic carbon content exiting the clarifier will be much reduced. Accordingly, less primary oxidizing agent will be needed to treat any remaining organic carbon.

Abstract: A dampening housing that may comprise a tubular structure, a chamber disposed within the tubular structure, and a first port disposed within the tubular structure about a first end of the chamber and providing fluid communication between the chamber to a wellbore. The dampening housing may further include a piston disposed within the chamber and configured to traverse the length of the chamber.