Abstract: Benzimidazole compounds that increase the rate of SOS-mediated nucleotide exchange on Ras by binding to a functionally relevant, chemically tractable pocket on the SOS protein, as part of the Ras:SOS:Ras complex.

Abstract: Described are N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)benzamide and acetamide-containing compounds that inhibit WDR5 and associated protein-protein interactions, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating disorders and conditions in a subject.

Abstract: Described are N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)benzamide and acetamide-containing compounds that inhibit WDR5 and associated protein-protein interactions, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating disorders and conditions in a subject.

Abstract: Techniques for reducing electronic resource consumption using a quality model are disclosed herein. In some embodiments, a data quality system receives a request from a first device of a first user of a social network service, identifies digital content based on the request, and accesses user data of the first user, with the user data of the first user comprising at least one of profile data of the first user and activity data of the first user. In some embodiments, the data quality system determines that the accessed user data of the first user does not satisfy a quality model, with the quality model requiring that at least two criteria of a plurality of criteria be satisfied by the accessed user data, and performs a restriction operation based on the determining that the accessed user data of the first user does not satisfy the quality model.

Abstract: Techniques for predicting relevance of social networking service member accounts to a job posting. In an embodiment, a candidate predictor engine of a system encodes data representing an applicant quality (AQ) score for each job/applicant pair for a plurality of applicants to a job posting. Additionally, the system stores the encoded data and assigns member-level weights to each of the applicants. Moreover, the system calculates weighted AQ scores for each of the job/applicant pairs, the weighted AQ scores being products of respective AQ scores and member-level weights. Furthermore, the system sums the weighted AQ scores to derive a total weighted score for the job posting. Then, the candidate predictor engine generates a job-level probability of confirmed hire (pCH) based on the total weighted score, the job-level pCH indicating a likelihood of the posting being filled by an applicant. Also, the system transmits the job-level pCH to a client for display.

Abstract: Described are compounds that disrupt the WDR5-MLL1 protein-protein interaction, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating disorders and conditions in a subject.

Abstract: Described are compounds that disrupt the WDR5-MLL1 protein-protein interaction, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating disorders and conditions in a subject.

Abstract: Disclosed are compounds which are tripeptides of the formula P-A-B-C or prodrugs thereof, wherein A is an amino acid having a carboxy alkyl group (e.g., carboxy C1-C6 alkyl group), B is tyrosine, phenylalanine, or a substituted tyrosine or phenylalanine, C is a hydrophobic amino acid, and P is an amine protecting group protecting the amine end of A. Also disclosed are pharmaceutical compositions comprising such a compound and a pharmaceutically acceptable carrier, and a method of treating an animal, e.g., a human, exposed to or infected by Yersinia pestis. The compounds find use as anti-bioterrorism agents.