Patents by Inventor Jason Pinkstaff

Jason Pinkstaff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Relaxin polypeptides comprising non-naturally encoded amino acids
    Patent number: 8735539
    Abstract: Modified relaxin polypeptides and their uses are provided. In one aspect, the disclosure provides a relaxin polypeptide comprising one or more non-naturally encoded amino acids. The polypeptide may be linked to a linker, polymer, or biologically active molecule. The serum half-life of the relaxin polypeptide may be enhanced relative to the unconjugated form. In another aspect, the disclosure provides methods of treating a patient having a disorder modulated by relaxin.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: May 27, 2014
    Assignee: Ambrx, Inc.
    Inventors: Vadim Kraynov, Nick Knudsen, Ahma Hewet, Kristine De Dios, Jason Pinkstaff, Lorraine Sullivan
  • Relaxin polypeptides comprising non-naturally encoded amino acids
    Patent number: 8691940
    Abstract: Modified relaxin polypeptides and their uses are provided. In one aspect, the disclosure provides a relaxin polypeptide comprising one or more non-naturally encoded amino acids. The polypeptide may be linked to a linker, polymer, or biologically active molecule. The serum half-life of the relaxin polypeptide may be enhanced relative to the unconjugated form. In another aspect, the disclosure provides methods of treating a patient having a disorder modulated by relaxin.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: April 8, 2014
    Assignee: Ambrx, Inc.
    Inventors: Vadim Kraynov, Nick Knudsen, Ahma Hewet, Kristine De Dios, Jason Pinkstaff, Lorraine Sullivan
  • MODIFIED RELAXIN POLYPEPTIDES AND THEIR USES
    Publication number: 20130237481
    Abstract: Modified relaxin polypeptides and their uses thereof are provided. Exemplary embodiments provide relaxin polypeptides which include one or more amino acid substitutions with natural or non-naturally encoded amino acids, and/or linkage to a water-soluble polymer, such as polyethylene glycol. Additionally, use of said relaxin polypeptides for treatment of disease, such as heart failure, is also provided.
    Type: Application
    Filed: February 22, 2013
    Publication date: September 12, 2013
    Inventors: Vadim Kraynov, Nick Knudsen, Amha Hewet, Kristine de Dios, Jason Pinkstaff, Lorraine Sullivan
  • Methods of making FGF-21 mutants comprising non-naturally encoded phenylalanine derivatives
    Patent number: 8383365
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: February 26, 2013
    Assignee: AMBRX, Inc.
    Inventors: Thomas P. Cujec, Roberto Mariani, Anna-Maria A. Hays Putnam, William M. Keefe, Nick Knudsen, Lillian Skidmore (Nee Ho), Jason Pinkstaff, Vadim Kraynov
  • Modified interferon beta polypeptides and their uses
    Patent number: 8329869
    Abstract: Modified interferon beta polypeptides and uses thereof are provided.
    Type: Grant
    Filed: January 6, 2012
    Date of Patent: December 11, 2012
    Assignee: Ambrx, Inc.
    Inventors: Vadim Kraynov, Nick Knudsen, Anna-Maria A. Hays Putnam, Denise Krawitz, Jason Pinkstaff, Heather Myler
  • MODIFIED INTERFERON BETA POLYPEPTIDES AND THEIR USES
    Publication number: 20120197006
    Abstract: Modified interferon beta polypeptides and uses thereof are provided.
    Type: Application
    Filed: January 6, 2012
    Publication date: August 2, 2012
    Applicant: AMBRX, INC.
    Inventors: Vadim KRAYNOV, Nick KNUDSEN, Anna-Maria A. HAYS PUTNAM, Denise KRAWITZ, Jason PINKSTAFF, Heather MYLER
  • Modified Leptin Polypeptides and Their Uses
    Publication number: 20120149636
    Abstract: Modified human leptin polypeptides and uses thereof are provided.
    Type: Application
    Filed: February 5, 2009
    Publication date: June 14, 2012
    Applicant: AMBRX, INC.
    Inventors: Vadim Kraynov, Anna-Maria A. Hays Putnam, Nick Knudsen, Jason Pinkstaff, Heather Myler, Lorraine Sullivan
  • MODIFIED RELAXIN POLYPEPTIDES AND THEIR USES
    Publication number: 20120046229
    Abstract: Modified relaxin polypeptides and their uses thereof are provided
    Type: Application
    Filed: August 17, 2011
    Publication date: February 23, 2012
    Applicant: AMBRX, INC.
    Inventors: Vadim KRAYNOV, Nick KNUDSEN, Amha HEWET, Kristine DE DIOS, Jason PINKSTAFF, Lorraine SULLIVAN
  • Modified interferon beta polypeptides and their uses
    Patent number: 8114630
    Abstract: Modified interferon beta polypeptides and uses thereof are provided.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: February 14, 2012
    Assignee: Ambrx, Inc.
    Inventors: Vadim Kraynov, Nick Knudsen, Anna-Maria A. Hays Putnam, Denise Krawitz, Jason Pinkstaff, Heather Myler
  • Modified FGF-21 polypeptides and their uses
    Patent number: 8012931
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: September 6, 2011
    Assignee: Ambrx, Inc.
    Inventors: Thomas P. Cujec, Roberto Mariani, Anna-Maria A. Hays Putnam, William M. Keefe, Nick Knudsen, Lillian Ho, Jason Pinkstaff, Vadim Kraynov
  • Modified FGF-21 Polypeptides and Their Uses
    Publication number: 20110172401
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Application
    Filed: March 18, 2011
    Publication date: July 14, 2011
    Applicant: AMBRX, INC.
    Inventors: Thomas P. CUJEC, Roberto MARIANI, Anna-Maria A. HAYS PUTNAM, William M. KEEFE, Nick KNUDSEN, Lillian Ho, Jason PINKSTAFF, Vadim KRAYNOV
  • Modified FGF-23 Polypeptides and Their Uses
    Publication number: 20110015345
    Abstract: Modified FGF-23 polypeptides and uses thereof are provided.
    Type: Application
    Filed: March 19, 2009
    Publication date: January 20, 2011
    Applicant: AMBRX, INC.
    Inventors: Jason Pinkstaff, Anna-Maria A Hays Putnam, Kristin S Eaton
  • MODIFIED INTERFERON BETA POLYPEPTIDES AND THEIR USES
    Publication number: 20090208454
    Abstract: Modified interferon beta polypeptides and uses thereof are provided.
    Type: Application
    Filed: April 30, 2008
    Publication date: August 20, 2009
    Applicant: AMBRX, INC.
    Inventors: Vadim KRAYNOV, Nick KNUDSEN, Anna-Maria A. HAYS PUTNAM, Denise KRAWITZ, Jason PINKSTAFF, Heather MYLER
  • Modified FGF-21 Polypeptides and Their Uses
    Publication number: 20080255045
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Application
    Filed: March 19, 2008
    Publication date: October 16, 2008
    Applicant: AMBRX, INC.
    Inventors: Thomas P. CUJEC, Roberto MARIANI, Anna-Maria A. HAYS PUTNAM, William M. KEEFE, Nick KNUDSEN, Lillian HO, Jason PINKSTAFF, Vadim KRAYNOV