Abstract: Disclosed herein are compositions and methods of treating disclosure provides for compounds for use in treating Mitochondrial Neurogastrointestinal Encephalopathy Syndrome (MNGIE). In some embodiments, the compounds have cell penetrating activity and thymidine phosphorylase activity. In certain embodiments, the compounds disclosed herein comprise: a) at least one cell-penetrating peptide (CPP) moiety; and b) a thymidine phosphorylase, or an active fragment or analog thereof (TP), wherein the CPP is coupled, directly or indirectly, to TP.

Abstract: This disclosure includes several different features suitable for use in circumaural and supra-aural headphones designs. Designs that include earpad assemblies that improve acoustic isolation are discussed. User convenience features that include automatically detecting the orientation of the headphones on a user's head are also discussed. Various power-saving features, design features, sensor configurations and user comfort features are also discussed.

Abstract: This application relates to earbuds configured with one or more biometric sensors. At least one of the biometric sensors is configured to be pressed up against a portion of the tragus for making biometric measurements. In some embodiments, the housing of the earbud can be symmetric so that the earbud can be worn interchangeably in either a left or a right ear of a user. In such an embodiment, the earbud can include a sensor and circuitry configured to determine and alter operation of the earbud in accordance to which ear the earbud is determined to be sitting in.

Abstract: A gastrostomy tube for insertion through an abdomen and into a stomach, including a cylindrical outer tube including a first proximal opening and a first distal opening, a flange surrounding the first proximal opening of the outer tube, a detachable cylindrical inner tube including a second proximal opening and a second distal opening, and one or more spokes attached to a distal end of the gastrostomy tube, wherein the one or more spokes include an actuatable portion configured to rotate the one or more spokes between a retracted position and an expanded position, wherein the inner tube is insertable into the first proximal opening of the outer tube, wherein the one or more spokes are rotatable into the expanded position when the inner tube is inserted through the first distal opening of the outer tube, and wherein the one or more spokes are substantially perpendicular to the outer tube in the expanded position.

Abstract: Described embodiments relate to motor control for synchronous motors, and more specifically, some embodiments relate to motor-current control for permanent-magnet synchronous motors. Embodiments of a current controller are described that include an adaptive controller configured to adapt to changing system dynamics of a PMSM. Embodiments of adaptive control techniques are described that involve estimating system parameters of a PMSM and adapting control actions to compensate for such estimated system parameters. Such adapted control actions may be expected to track an observed motor current to a desired motor current. Systems, methods and devices related to the above are also described.

Abstract: Described embodiments relate to motor control for synchronous motors, and more specifically, some embodiments relate to motor-current control for permanent-magnet synchronous motors. Embodiments of a current controller are described that include an adaptive controller configured to adapt to changing system dynamics of a PMSM. Embodiments of adaptive control techniques are described that involve estimating system parameters of a PMSM and adapting control actions to compensate for such estimated system parameters. Such adapted control actions may be expected to track an observed motor current to a desired motor current. Systems, methods and devices related to the above are also described.