Abstract: A suspension of a therapeutic substance (e.g., embolic beads) dispersed within a liquid can be delivered via a catheter by using a bidirectional pump to rapidly draw the mixture of the therapeutic substance and liquid from an external syringe into an internal reservoir, then rapidly push the mixture back out into the external syringe. The rapid operation of the bidirectional pump mixes the two constituents so that the therapeutic substance is temporarily suspended within the liquid. Then, a low-speed pump is used to inject the mixture out via the catheter. In some embodiments, the parameters of the low-speed pump are controlled so that the fluid exiting the catheter will experience laminar flow. When the therapeutic substance comprises embolic beads, this can advantageously prevent reflux of the embolic beads, which can be dangerous.

Abstract: An endoscopy device is configured with a flexible cannula or tube for nasal insertion and has multiple parallel and adjacent lumens that provide sub-chambers configured to provide means to diagnose and treat Barrett's esophagus, such as by spray cryo-therapy with no further insertion of tubes. The lumens are configured to impart a small diameter with sufficient flexibility for nasal insertion into a patient's esophagus and accommodate a means any treatment modality. In the case of cryo-therapy, a lumen provides gas pressure relief, and is along the tube, with separate lumens for the delivery of a liquid freezing agent and an imaging means, which includes a source of illumination. Outer lumens may support guide wires used to steer the tube tip and aim the camera to determine the where to immobilize tip before the start of the treatment and/or to correct strictures formed in prior procedures.

Abstract: A suspension of a therapeutic substance (e.g., embolic beads) dispersed within a liquid can be delivered via a catheter by using a bidirectional pump to rapidly draw the mixture of the therapeutic substance and liquid from an external syringe into an internal reservoir, then rapidly push the mixture back out into the external syringe. The rapid operation of the bidirectional pump mixes the two constituents so that the therapeutic substance is temporarily suspended within the liquid. Then, a low-speed pump is used to inject the mixture out via the catheter. In some embodiments, the parameters of the low-speed pump are controlled so that the fluid exiting the catheter will experience laminar flow. When the therapeutic substance comprises embolic beads, this can advantageously prevent reflux of the embolic beads, which can be dangerous.