Abstract: The present disclosure includes computing device related, systems, and methods for IPR planning as described herein. One method includes identifying a first tooth and a second tooth in a digital dental model with an overlap in a target final position in a treatment plan and identifying a reference line on each of the first tooth and the second tooth; revising the treatment plan wherein a position of each of the first tooth and the second tooth is determined in which the reference line of each of the first tooth and the second tooth are aligned and the first tooth and second tooth are not overlapping; and prescribing IPR based on the determined position of each of the first tooth and the second tooth.

Abstract: A method may include: receiving an image of a mouth region of a patient's face; extracting teeth contours within the image of the mouth region of the patient's face; locating a mouth opening within the image of the mouth region of the patient's face; extracting the tooth contours from a 3D model of the patient's teeth; and aligning the tooth contours from the 3D model with the tooth contours of the teeth within the image of the mouth region of the patient's face.

Abstract: The example systems, methods, and/or computer-readable media described herein help with design treatment plans for orthodontic treatments. Treatment templates expressed according to treatment domain-specific protocols may be processed to provide treatment planning software, including automated or real-time treatment planning software, that accommodates treatment preferences of a practitioner and/or patient data relevant to a treatment plan. These methods and systems may be also be useful for planning, designing and producing as series of dental appliances (e.g., aligners).

Abstract: The example systems, methods, and/or computer-readable media described herein help with design treatment plans for orthodontic treatments. Treatment templates expressed according to treatment domain-specific protocols may be processed to provide treatment planning software, including automated or real-time treatment planning software, that accommodates treatment preferences of a practitioner and/or patient data relevant to a treatment plan. These methods and systems may be also be useful for planning, designing and producing as series of dental appliances (e.g., aligners).

Abstract: The example systems, methods, and/or computer-readable media described herein help with design treatment plans for orthodontic treatments. Treatment templates expressed according to treatment domain-specific protocols may be processed to provide treatment planning software, including automated or real-time treatment planning software, that accommodates treatment preferences of a practitioner and/or patient data relevant to a treatment plan. These methods and systems may be also be useful for planning, designing and producing as series of dental appliances (e.g., aligners).

Abstract: Orthodontic and/or dental treatment planning methods and apparatuses. In particular, described herein are methods of generating a plurality of potential treatment plan variations for the concurrent and interactive review of the treatment plan variations. Each variation may be optimized to best address the user's treatment goals, as well as approximating as closely as possible an ideal or target final position. Also described herein are orthodontic and/or dental treatment planning methods and apparatuses that allow a user to form, modify, and select a treatment plan from a plurality of different treatment plans, in real time.

Abstract: Methods and systems are provided for manufacturing an appliance for correcting malocclusions of a patient's teeth. The method may include measuring the positions of a patient's teeth and receiving tooth movement constraints. The method may also include generating an initial treatment plan based on the measured tooth positions and the tooth movement constraints and measuring the malocclusions of the patient's teeth for one or more types of dental malocclusions. The method may also include generating a plurality of treatment plans from the initial treatment plan based on the measured malocclusion and generating a model of an appliance for each stage of the treatment plan. The method may also include generating instructions for fabricating the appliance for each stage of the treatment plan based on the model of the appliance for each stage of the treatment plan.

Abstract: A computer-implemented method for virtually representing an orthodontic treatment outcome using automated detection of facial and dental reference objects is disclosed herein. The computer-implemented method may involve modeling initial positions of an orthodontic patient's teeth in a three-dimensional (3D) virtual model and determining the effect of application of various force systems applied through an orthodontic treatment plan on the patient's teeth. Images of the patient's face may be used to identify facial reference objects. Dental reference objects of the patient's dentition may be identified from the 3D virtual model. A relationship between the facial reference objects and the dental reference objects may form the basis of modifications to the orthodontic treatment plan and/or modeling final orthodontic positions of the orthodontic treatment plan.

Abstract: A method may include: receiving an image of a mouth region of a patient's face; extracting teeth contours within the image of the mouth region of the patient's face; locating a mouth opening within the image of the mouth region of the patient's face; extracting the tooth contours from a 3D model of the patient's teeth; and aligning the tooth contours from the 3D model with the tooth contours of the teeth within the image of the mouth region of the patient's face.

Abstract: A computer-implemented method for generating a virtual depiction of an orthodontic treatment of a patient is disclosed herein. The computer-implemented method may involve gathering a three-dimensional (3D) model modeling the patient's dentition at a specific treatment stage of an orthodontic treatment plan. An image of the patient's face and dentition may be gathered. A first set of reference points modeled on the 3D model of the patient's dentition and a second set of reference points represented on the dentition of the image of the patient may be received. The image of the patient's dentition may be projected into a 3D space to create a projected 3D model of the image of the patient's dentition. Based on a comparison of the first reference points and projections of the second set of reference points, a modified image of the patient may be constructed and/or modeled.

Abstract: The present disclosure includes computing device related, systems, and methods for IPR planning as described herein. One method includes identifying a first tooth and a second tooth in a digital dental model with an overlap in a target final position in a treatment plan and identifying a reference line on each of the first tooth and the second tooth; revising the treatment plan wherein a position of each of the first tooth and the second tooth is determined in which the reference line of each of the first tooth and the second tooth are aligned and the first tooth and second tooth are not overlapping; and prescribing IPR based on the determined position of each of the first tooth and the second tooth.

Abstract: The present disclosure includes computing device related, systems, and methods for IPR planning as described herein. One method includes identifying a first tooth and a second tooth in a digital dental model with an overlap in a target final position in a treatment plan and identifying a reference line on each of the first tooth and the second tooth; revising the treatment plan wherein a position of each of the first tooth and the second tooth is determined in which the reference line of each of the first tooth and the second tooth are aligned and the first tooth and second tooth are not overlapping; and prescribing IPR based on the determined position of each of the first tooth and the second tooth.

Abstract: The present disclosure includes computing device related, systems, and methods for IPR planning as described herein. One method includes identifying a first tooth and a second tooth in a digital dental model with an overlap in a target final position in a treatment plan and identifying a reference line on each of the first tooth and the second tooth; revising the treatment plan wherein a position of each of the first tooth and the second tooth is determined in which the reference line of each of the first tooth and the second tooth are aligned and the first tooth and second tooth are not overlapping; and prescribing IPR based on the determined position of each of the first tooth and the second tooth.

Abstract: Described herein are methods for using calcium flux as a biomarker to select and predict patients likely to respond to an apoptotic agent as therapy. Further described herein is a method of using calcium flux as a clinical biomarker to determine whether a tumor is sensitive to an HDAC inhibitor.