Abstract: The disclosure relates to compounds of Formula I, methods of making same, pharmaceutical compositions including same, and methods of treating pain and neurological disorders using same: wherein R1 is hydrogen, halogen, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, aryl, nitro, or cyano; wherein R2 and R3 are independently hydrogen, halogen, aryl, or substituted or unsubstituted alkyl, or wherein R2 and R3 are connected to form an alkyl chain; wherein R4 is a substituted or unsubstituted aryl or heteroaryl group having from 5 to 10 members; wherein X is O, S, N, NH, CH, CH2, or CO; wherein n is from 0 to 10; and wherein the bond indicated by * is a double bond or a single bond based on a valence of X. The compounds selectively bind to CB2, can penetrate the blood brain barrier, and have a half-life of 20 hours or greater.