Patents by Inventor Jason Robert Hyde
Jason Robert Hyde has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11913936Abstract: An apparatus for supporting an array of layers of amphiphilic molecules, the apparatus comprising: a body, formed in a surface of the body, an array of sensor wells capable of supporting a layer of amphiphilic molecules across the sensor wells, the sensor wells each containing an electrode for connection to an electrical circuit, and formed in the surface of the body between the sensor wells, flow control wells capable of smoothing the flow of a fluid across the surface.Type: GrantFiled: December 20, 2022Date of Patent: February 27, 2024Assignee: Oxford Nanopore Technologies PLCInventors: Jason Robert Hyde, James Anthony Clarke, Gaëlle Anne-Leonie Andreatta
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Publication number: 20230228733Abstract: An apparatus for supporting an array of layers of amphiphilic molecules, the apparatus comprising: a body, formed in a surface of the body, an array of sensor wells capable of supporting a layer of amphiphilic molecules across the sensor wells, the sensor wells each containing an electrode for connection to an electrical circuit, and formed in the surface of the body between the sensor wells, flow control wells capable of smoothing the flow of a fluid across the surface.Type: ApplicationFiled: December 20, 2022Publication date: July 20, 2023Applicant: Oxford Nanopore Technologies PLCInventors: Jason Robert Hyde, James Anthony Clarke, Gaëlle Anne-Leonie Andreatta
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Publication number: 20230228732Abstract: There is disclosed a nanopore support structure comprising a wall layer comprising walls defining a plurality of wells, and overhangs extending from the walls across each of the wells, the overhang defining an aperture configured to support a membrane suitable for insertion of a nanopore. There is further disclosed a nanopore sensing device comprising a nanopore support structure, and methods of manufacturing the nanopore support structure and the nanopore sensing device.Type: ApplicationFiled: April 29, 2021Publication date: July 20, 2023Applicant: Oxford Nanopore Technologies PLCInventors: Ping Xie, Justin Millis, Ken Healy, James Anthony Clarke, Jason Robert Hyde, Richard Kenneth John Wiltshire, Jonathan Edward McKendry, Robert Greasty, Clive Gavin Brown, loana Pera, Gurdial Singh Sanghera, Mark Hyland, Pedro Miguel Ortiz Bahamon, Mark David Jackson, Paul Raymond Mackett, Rhodri Rhys Davies
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Publication number: 20230158503Abstract: Droplet interfaces are formed between droplets in an electro-wetting device comprising an array of actuation electrodes. Actuation signals are applied to selected actuation electrodes to place the droplets into an energised state in which the shape of the droplets is modified compared to a shape of the droplets in a lower energy state and to bring the two droplets into proximity. The actuation signals are then changed to lower the energy of the droplets into the lower energy state so that the droplets relax into the gap and the two droplets contact each other thereby forming a droplet interface. The use of sensing electrodes in the device permit electrical current measurements across the droplet interface. The sensing electrodes can be used for either (i) applying a reference signal during droplet actuation or (ii) recording electrical current measurements.Type: ApplicationFiled: November 18, 2022Publication date: May 25, 2023Applicants: Oxford Nanopore Technologies PLC, Sharp Life Science EU (Ltd)Inventors: Matthew Holden, James White, Andrew John Heron, James Anthony Clarke, Jason Robert Hyde, Benjamin James Hadwen, Sally Anderson
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Publication number: 20230041418Abstract: Provided herein is a method of concentrating a tethering complex in a region of an amphiphilic layer, such as a lipid membrane. Also provided herein are methods of assembling a tethering complex; methods of concentrating an analyte in the region of a detector; amphiphilic layers; and arrays and devices for use in the disclosed methods.Type: ApplicationFiled: December 3, 2020Publication date: February 9, 2023Applicant: Oxford Nanopore Technologies PLCInventors: Clive Gavin Brown, Andrew John Heron, James Anthony Clarke, Paul Richard Moody, Aaron Luke Acton, Jason Robert Hyde
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Patent number: 11561216Abstract: An apparatus for supporting an array of layers of amphiphilic molecules, the apparatus comprising: a body, formed in a surface of the body, an array of sensor wells capable of supporting a layer of amphiphilic molecules across the sensor wells, the sensor wells each containing an electrode for connection to an electrical circuit, and formed in the surface of the body between the sensor wells, flow control wells capable of smoothing the flow of a fluid across the surface.Type: GrantFiled: May 6, 2019Date of Patent: January 24, 2023Assignee: Oxford Nanopore Technologies PLCInventors: Jason Robert Hyde, James Anthony Clarke, Gaëlle Anne-Leonie Andreatta
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Patent number: 11534763Abstract: Droplet interfaces are formed between droplets in an electro-wetting device comprising an array of actuation electrodes. Actuation signals are applied to selected actuation electrodes to place the droplets into an energised state in which the shape of the droplets is modified compared to a shape of the droplets in a lower energy state and to bring the two droplets into proximity. The actuation signals are then changed to lower the energy of the droplets into the lower energy state so that the droplets relax into the gap and the two droplets contact each other thereby forming a droplet interface. The use of sensing electrodes in the device permit electrical current measurements across the droplet interface. The sensing electrodes can be used for either (i) applying a reference signal during droplet actuation or (ii) recording electrical current measurements.Type: GrantFiled: December 21, 2018Date of Patent: December 27, 2022Assignees: Oxford Nanopore Technologies PLC, Sharp Life Science EU (Ltd)Inventors: Matthew Holden, James White, Andrew John Heron, James Anthony Clarke, Jason Robert Hyde, Benjamin James Hadwen, Sally Anderson
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Publication number: 20220396013Abstract: The invention relates to a method of forming a sensing device for supporting a plurality of nanopores upon an array of wells. The method involves providing a substrate, said substrate having a surface having an array of electrodes located thereon for connecting to or for configuring upon an electronic circuit. Separately, a well array structure is provided, which has an array of walls defining through-holes for defining wells. The substrate and well array structures are aligning said array of electrodes define, at least in part, a portion of the bases of respective wells at the bottom of the through holes. The resulting sensing device overcomes problems with known sensing devices by employing a substrate and/or well array structure, or hybrid thereof, that employs alternative materials or manufacturing processes.Type: ApplicationFiled: October 23, 2020Publication date: December 15, 2022Applicant: Oxford Nanopore Technologies PLCInventors: Pedro Miguel Ortiz Bahamon, Paul Raymond Mackett, Robert Greasty, Jonathan Edward McKendry, Jason Robert Hyde, Mark David Jackson, Richard Kenneth John Wiltshire, Rhodri Rhys Davies, Mark Hyland, James Anthony Clarke, Gurdial Singh Sanghera
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Publication number: 20220023819Abstract: An array of membranes comprising amphipathic molecules is formed using an apparatus comprising a support defining an array of compartments. Volumes comprising polar medium are provided within respective compartments and a layer comprising apolar medium is provided extending across the openings with the volumes. Polar medium is flowed across the support to displace apolar medium and form a layer in contact with the volumes, forming membranes comprising amphipathic molecules at the interfaces. In one construction of the apparatus, the support that comprises partitions which comprise inner portions and outer portions. The inner portions define inner recesses without gaps therebetween that are capable of constraining the volumes comprising polar medium contained in neighbouring inner recesses from contacting each other. The outer portions extend outwardly from the inner portions and have gaps allowing the flow of an apolar medium across the substrate.Type: ApplicationFiled: July 1, 2021Publication date: January 27, 2022Applicant: Oxford Nanopore Technologies Ltd.Inventors: Jason Robert Hyde, Pedro Miguel Ortiz Bahamon, Clive Gavin Brown, Andrew John, Paul Raymond Mackett
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Patent number: 11084015Abstract: An array of membranes comprising amphipathic molecules is formed using an apparatus comprising a support defining an array of compartments. Volumes comprising polar medium are provided within respective compartments and a layer comprising apolar medium is provided extending across the openings with the volumes. Polar medium is flowed across the support to displace apolar medium and form a layer in contact with the volumes, forming membranes comprising amphipathic molecules at the interfaces. In one construction of the apparatus, the support that comprises partitions which comprise inner portions and outer portions. The inner portions define inner recesses without gaps therebetween that are capable of constraining the volumes comprising polar medium contained in neighbouring inner recesses from contacting each other. The outer portions extend outwardly from the inner portions and have gaps allowing the flow of an apolar medium across the substrate.Type: GrantFiled: September 30, 2020Date of Patent: August 10, 2021Assignee: Oxford Nanopore Technologies Ltd.Inventors: Jason Robert Hyde, Pedro Miguel Ortiz Bahamon, Clive Gavin Brown, Andrew John Heron, Paul Raymond Mackett
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Publication number: 20210086160Abstract: An array of membranes comprising amphipathic molecules is formed using an apparatus comprising a support defining an array of compartments. Volumes comprising polar medium are provided within respective compartments and a layer comprising apolar medium is provided extending across the openings with the volumes. Polar medium is flowed across the support to displace apolar medium and form a layer in contact with the volumes, forming membranes comprising amphipathic molecules at the interfaces. In one construction of the apparatus, the support that comprises partitions which comprise inner portions and outer portions. The inner portions define inner recesses without gaps therebetween that are capable of constraining the volumes comprising polar medium contained in neighbouring inner recesses from contacting each other. The outer portions extend outwardly from the inner portions and have gaps allowing the flow of an apolar medium across the substrate.Type: ApplicationFiled: September 30, 2020Publication date: March 25, 2021Applicant: Oxford Nanopore Technologies Ltd.Inventors: Jason Robert Hyde, Pedro Miguel Ortiz Bahamon, Clive Gavin Brown, Andrew John Heron, Paul Raymond Mackett
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Publication number: 20210008557Abstract: Droplet interfaces are formed between droplets in an electro-wetting device comprising an array of actuation electrodes. Actuation signals are applied to selected actuation electrodes to place the droplets into an energised state in which the shape of the droplets is modified compared to a shape of the droplets in a lower energy state and to bring the two droplets into proximity. The actuation signals are then changed to lower the energy of the droplets into the lower energy state so that the droplets relax into the gap and the two droplets contact each other thereby forming a droplet interface. The use of sensing electrodes in the device permit electrical current measurements across the droplet interface. The sensing electrodes can be used for either (i) applying a reference signal during droplet actuation or (ii) recording electrical current measurements.Type: ApplicationFiled: December 21, 2018Publication date: January 14, 2021Applicants: Oxford Nanopore Technologies Ltd., Sharp Life Science (EU) LtdInventors: Matthew HOLDEN, James WHITE, Andrew John HERON, James Anthony CLARKE, Jason Robert HYDE, Benjamin James HADWEN, Sally ANDERSON
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Patent number: 10814298Abstract: An array of membranes comprising amphipathic molecules is formed using an apparatus comprising a support defining an array of compartments. Volumes comprising polar medium are provided within respective compartments and a layer comprising apolar medium is provided extending across the openings with the volumes. Polar medium is flowed across the support to displace apolar medium and form a layer in contact with the volumes, forming membranes comprising amphipathic molecules at the interfaces. In one construction of the apparatus, the support that comprises partitions which comprise inner portions and outer portions. The inner portions define inner recesses without gaps therebetween that are capable of constraining the volumes comprising polar medium contained in neighbouring inner recesses from contacting each other. The outer portions extend outwardly from the inner portions and have gaps allowing the flow of an apolar medium across the substrate.Type: GrantFiled: October 23, 2013Date of Patent: October 27, 2020Assignee: Oxford Nanopore Technologies Ltd.Inventors: Jason Robert Hyde, Pedro Miguel Ortiz Bahamon, Clive Gavin Brown, Andrew John Heron, Paul Raymond Mackett
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Patent number: 10549274Abstract: A detachable electrical device can be formed from a kit comprising a pair of component parts adapted for connection to each other, wherein the connected components of the device may be subsequently disconnected, comprising: an array of electrical connectors, each electrical connector comprising an electrically conductive liquid; and an array of electrodes; wherein the arrays can be brought into contact with each other so as to provide a plurality of electrical connections between the electrically conductive liquid of the array of electrical connectors and the electrodes of the array of electrodes, and wherein the electrical connections may be subsequently broken by detaching the electrically conductive liquid from the electrodes of the array.Type: GrantFiled: October 15, 2015Date of Patent: February 4, 2020Assignee: Oxford Nanopore Technologies Ltd.Inventors: Clive Gavin Brown, Jason Robert Hyde, Mark David Jackson, Paul Raymond Mackett, Jonathan Edward McKendry, Richard Kenneth John Wiltshire
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Publication number: 20190391128Abstract: An apparatus for supporting an array of layers of amphiphilic molecules, the apparatus comprising: a body, formed in a surface of the body, an array of sensor wells capable of supporting a layer of amphiphilic molecules across the sensor wells, the sensor wells each containing an electrode for connection to an electrical circuit, and formed in the surface of the body between the sensor wells, flow control wells capable of smoothing the flow of a fluid across the surface.Type: ApplicationFiled: May 6, 2019Publication date: December 26, 2019Applicant: Oxford Nanopore Technologies Ltd.Inventors: Jason Robert Hyde, James Anthony Clarke, Gaëlle Anne-Leonie Andreatta
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Patent number: 10338056Abstract: An apparatus for supporting an array of layers of amphiphilic molecules, the apparatus comprising: a body (11), formed in a surface of the body, an array of sensor wells (10) capable of supporting a layer of amphiphilic molecules (30) across the sensor wells, the sensor wells each containing an electrode (12) for connection to an electrical circuit, and formed in the surface of the body between the sensor wells, flow control wells capable of smoothing the flow of a fluid across the surface.Type: GrantFiled: February 13, 2013Date of Patent: July 2, 2019Assignee: Oxford Nanopore Technologies Ltd.Inventors: Jason Robert Hyde, James Anthony Clarke, Gaëlle Anne-Leonie Andreatta
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Patent number: 9823235Abstract: The invention provides a method of forming a membrane between a first volume of polar medium and a second volume of polar medium. In some embodiments, the method involves providing a first volume including polar medium and a second volume including polar medium which are separated from one another by an apolar medium, in which at least one of the first and second volumes has a layer including amphipathic molecules.Type: GrantFiled: October 23, 2013Date of Patent: November 21, 2017Assignee: Oxford Nanopre Technologies Ltd.Inventors: Andrew John Heron, Jason Robert Hyde, Clive Gavin Brown
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Publication number: 20170326550Abstract: A detachable electrical device can be formed from a kit comprising a pair of component parts adapted for connection to each other, wherein the connected components of the device may be subsequently disconnected, comprising: an array of electrical connectors, each electrical connector comprising an electrically conductive liquid; and an array of electrodes; wherein the arrays can be brought into contact with each other so as to provide a plurality of electrical connections between the electrically conductive liquid of the array of electrical connectors and the electrodes of the array of electrodes, and wherein the electrical connections may be subsequently broken by detaching the electrically conductive liquid from the electrodes of the array.Type: ApplicationFiled: October 15, 2015Publication date: November 16, 2017Applicant: Oxford Nanopore Technologies Ltd.Inventors: Clive Gavin Brown, Jason Robert Hyde, Mark David Jackson, Paul Raymond Mackett, Jonathan Edward Mckendry, Richard Kenneth John Wiltshire
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Publication number: 20150285781Abstract: The invention provides a method of forming a membrane between a first volume of polar medium and a second volume of polar medium, which method comprises: (a) providing a first volume comprising polar medium and a second volume comprising polar medium which are separated from one another by an apolar medium, wherein at least one of said first and second volumes comprises a layer comprising amphipathic molecules, at the interface between the polar medium and the apolar medium, wherein each of the amphipathic molecules comprises a first outer hydrophilic group, a hydrophobic core group, and a second outer hydrophilic group, wherein each of the first and second outer hydrophilic groups is linked to the hydrophobic core group; and (b) causing the first and second volumes to come into contact with one another to form a membrane comprising said amphipathic molecules between the first and second volumes.Type: ApplicationFiled: October 23, 2013Publication date: October 8, 2015Applicant: Oxford Nanopore Technologies Ltd.Inventors: Andrew John Heron, Jason Robert Hyde, Clive Gavin Brown
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Publication number: 20150265994Abstract: An array of membranes comprising amphipathic molecules is formed using an apparatus comprising a support defining an array of compartments. Volumes comprising polar medium are provided within respective compartments and a layer comprising apolar medium is provided extending across the openings with the volumes. Polar medium is flowed across the support to displace apolar medium and form a layer in contact with the volumes, forming membranes comprising amphipathic molecules at the interfaces. In one construction of the apparatus, the support that comprises partitions which comprise inner portions and outer portions. The inner portions define inner recesses without gaps therebetween that are capable of constraining the volumes comprising polar medium contained in neighbouring inner recesses from contacting each other. The outer portions extend outwardly from the inner portions and have gaps allowing the flow of an apolar medium across the substrate.Type: ApplicationFiled: October 23, 2013Publication date: September 24, 2015Applicant: Oxford Nanopore Technologies Ltd.Inventors: Jason Robert Hyde, Pedro Miguel Ortiz Bahamon, Clive Gavin Brown, Andrew John Heron, Paul Raymond Mackett