Patents by Inventor Jason Robert ZBIEG

Jason Robert ZBIEG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic compounds and methods of use
    Patent number: 12275745
    Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.
    Type: Grant
    Filed: November 21, 2022
    Date of Patent: April 15, 2025
    Assignee: GENENTECH, INC.
    Inventors: Jason Robert Zbieg, Paul Powell Beroza, Vishal Anil Verma, Bing-Yan Zhu, Ramsay Beveridge, Liang Zhao, Melissa Leblanc, Lisa Marie Barton, Bryan Ka Ip Chan, Samir Bouayad-Gervais, Anwesha Dey, Marie Anne Evangelista, Russell Tyler Smith
  • THERAPEUTIC COMPOUNDS AND METHODS OF USE
    Publication number: 20250074881
    Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.
    Type: Application
    Filed: September 3, 2024
    Publication date: March 6, 2025
    Applicant: Genentech, Inc.
    Inventors: Jason Robert ZBIEG, Russell Tyler SMITH, Paul Powell BEROZA, Vishal Anil VERMA, Bing-Yan ZHU, Ramsay BEVERIDGE, Lisa Marie BARTON, Bryan Ka Ip CHAN, Curtis COLWELL, Samir BOUAYAD-GERVAIS, Anwesha DEY, Marie Anne EVANGELISTA
  • Lactams as CBL-B inhibitors selective over C-CBL
    Patent number: 12187709
    Abstract: A compound, of formula (I): suitable for treating a cancer wherein the cancer is susceptible to inhibition of Cbl-B.
    Type: Grant
    Filed: November 4, 2022
    Date of Patent: January 7, 2025
    Assignee: Genentech, Inc.
    Inventors: Malcolm Huestis, Michael John Lambrecht, Jun Liang, Man Un Ung, Xiaojing Wang, Jason Robert Zbieg, Bing-Yan Zhu, Lisa Marie Barton, Fabio Broccatelli, Georgette Marie Castanedo, Araz Jakalian, Robin Larouche-Gauthier, Arun Yadav
  • Pyrazolo compounds and methods of use thereof
    Patent number: 12110276
    Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.
    Type: Grant
    Filed: November 21, 2022
    Date of Patent: October 8, 2024
    Assignee: GENENTECH, INC.
    Inventors: Jason Robert Zbieg, Russell Tyler Smith, Paul Powell Beroza, Vishal Anil Verma, Bing-Yan Zhu, Ramsay Beveridge, Lisa Marie Barton, Bryan Ka Ip Chan, Curtis Colwell, Samir Bouayad-Gervais, Anwesha Dey, Marie Anne Evangelista
  • AMIDES AS CBL-B INHIBITORS
    Publication number: 20240300927
    Abstract: Various amide compounds that bind Cbl-B, including those that are selective for C-Cbl, and methods of making and using the same.
    Type: Application
    Filed: February 3, 2022
    Publication date: September 12, 2024
    Applicant: Genentech, Inc.
    Inventors: Jun Liang, Araz Jakalian, Michael John Lambrecht, Robin Larouche-Gauthier, Malcolm Huestis, Man Un Ung, Xiaojing Wang, Arun Yadav, Jason Robert Zbieg, Fabio Broccatelli
  • HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS
    Publication number: 20230242506
    Abstract: The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.
    Type: Application
    Filed: September 2, 2022
    Publication date: August 3, 2023
    Applicant: GENENTECHT, INC.
    Inventors: Jason Robert Zbieg, Elisia Villemure, Joachim Rudolph, Paul Powell Beroza, James John Crawford
  • LACTAMS AS CBL-B INHIBITORS SELECTIVE OVER C-CBL
    Publication number: 20230212153
    Abstract: A compound, of formula (I): suitable for treating a cancer wherein the cancer is susceptible to inhibition of Cbl-B.
    Type: Application
    Filed: November 4, 2022
    Publication date: July 6, 2023
    Applicant: Genentech, Inc.
    Inventors: Malcolm HUESTIS, Michael John LAMBRECHT, Jun LIANG, Man Un UNG, Xiaojing WANG, Jason Robert ZBIEG, Bing-Yan Zhu, Lisa Marie BARTON, Fabio BROCCATELLI, Georgette Marie CASTANEDO, Araz JAKALIAN, Robin LAROUCHE-GAUTHIER, Arun YADAV
  • THERAPEUTIC COMPOUNDS AND METHODS OF USE
    Publication number: 20230202984
    Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.
    Type: Application
    Filed: November 21, 2022
    Publication date: June 29, 2023
    Applicant: Genentech, Inc.
    Inventors: Jason Robert Zbieg, Russell Tyler Smith, Paul Powell Beroza, Vishal Anil Verma, Bing-Yan Zhu, Ramsay Beveridge, Lisa Marie Barton, Bryan Ka lp Chan, Curtis Colwell, Samir Bouayad-Gervais, Anwesha Dey, Marie Anne Evangelista
  • THERAPEUTIC COMPOUNDS AND METHODS OF USE
    Publication number: 20230203062
    Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.
    Type: Application
    Filed: November 21, 2022
    Publication date: June 29, 2023
    Applicant: Genentech, Inc.
    Inventors: Jason Robert ZBIEG, Paul Powell BEROZA, Vishal Anil VERMA, Bing-Yan ZHU, Ramsay BEVERIDGE, Liang ZHAO, Melissa LEBLANC, Lisa Marie BARTON, Bryan Ka Ip CHAN, Samir BOUAYAD-GERVAIS, Anwesha DEY, Marie Anne EVANGELISTA, Russell Tyler SMITH
  • LACTAMS AS CBL-B INHIBITORS
    Publication number: 20230079990
    Abstract: Various lactam compound that binds Cbl-B, many of which are selective for Cbl-B over C-Cbl, and methods of making and using the same.
    Type: Application
    Filed: February 3, 2022
    Publication date: March 16, 2023
    Applicant: Genentech, Inc.
    Inventors: Jun LIANG, Araz JAKALIAN, Michael John LAMBRECHT, Robin LAROUCHE-GAUTHIER, Malcolm HUESTIS, Man Un UNG, Xiaojing WANG, Arun YADAV, Jason Robert ZBIEG, Fabio BROCCATELLI
  • THERAPEUTIC COMPOUNDS
    Publication number: 20230002396
    Abstract: The present disclosure relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, and compositions and uses thereof. The compounds are useful as inhibitors of the YAP:TEAD protein:protein interaction. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various YAP:TEAD-mediated disorders, including cancer.
    Type: Application
    Filed: May 26, 2022
    Publication date: January 5, 2023
    Applicant: Genentech, Inc.
    Inventors: James John Crawford, Jason Robert Zbieg
  • THERAPEUTIC COMPOUNDS AND METHODS OF USE
    Publication number: 20220281819
    Abstract: The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.
    Type: Application
    Filed: May 12, 2022
    Publication date: September 8, 2022
    Applicant: Genentech, Inc.
    Inventors: Jason Robert Zbieg, James John Crawford, Christian N. Cunningham
  • THERAPEUTIC COMPOUNDS
    Publication number: 20210238184
    Abstract: The present disclosure relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R3 have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of the YAP:TEAD protein:protein interaction. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various YAP:TEAD-mediated disorders, including cancer.
    Type: Application
    Filed: November 25, 2020
    Publication date: August 5, 2021
    Applicant: Genentech, Inc.
    Inventors: Jason Robert Zbieg, Paul Powell Beroza, James John Crawford
  • CARBOXAMIDE AND SULFONAMIDE DERIVATIVES USEFUL AS TEAD MODULATORS
    Publication number: 20210188775
    Abstract: The invention is concerned with the compounds of formula (I) and formula (II): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of using the compounds of formula (I) and formula (II) as well as pharmaceutical compositions containing such compounds. The compounds are useful in treating diseases and conditions mediated by TEAD, such as cancer.
    Type: Application
    Filed: March 2, 2021
    Publication date: June 24, 2021
    Applicant: Genentech, Inc.
    Inventors: Christian CUNNINGHAM, Paul Powell BEROZA, James John CRAWFORD, Wendy Lee, Olivier RENE, Jason Robert ZBIEG, Jiangpeng LIAO, Tao WANG, Chen YU