Abstract: An articulating surgical instrument includes a housing, a shaft extending distally from the housing, an end effector assembly, and an articulating component interconnecting the shaft and end effector assembly. The articulating component includes a proximal disk connected to the shaft, a distal disk connected to the end effector assembly, an intermediate disk, a first flexible interconnect connecting the proximal and intermediate disks, and a second flexible interconnect connecting the intermediate and distal disks. The first flexible interconnect defines a single plane of bending to enable articulation of the end effector assembly relative to the shaft within a first plane. The second flexible interconnect defines a single plane of bending substantially perpendicular to the single plane of bending of the first flexible interconnect to enable articulation of the end effector assembly relative to the shaft within a second plane substantially perpendicular to the first plane.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: The innovation supports the ability to map alpha characters entered directly into the dialer application of a smartphone. These alpha characters can be entered via a smartphone keyboard (e.g., QWERTY keyboard) and converted to the appropriate digits as mapped to a conventional telephone keypad. The resultant numerical digits can be used to prompt a network call. Additionally, the innovation can be used during an active call to respond to prompts that traditionally require 12-key mappings. This innovation allows a user to both dial a number directly via a smartphone keyboard, and filter contacts by name, in a non-modal manner.

Abstract: The innovation supports the ability to map alpha characters entered directly into the dialer application of a smartphone. These alpha characters can be entered via a smartphone keyboard (e.g., QWERTY keyboard) and converted to the appropriate digits as mapped to a conventional telephone keypad. The resultant numerical digits can be used to prompt a network call. Additionally, the innovation can be used during an active call to respond to prompts that traditionally require 12-key mappings. This innovation allows a user to both dial a number directly via a smartphone keyboard, and filter contacts by name, in a non-modal manner.

Abstract: The present invention provides an interface and associated object model that exposes a comprehensive set of natural language processing features to an application developer. In one embodiment, the features include lexicon management services and proofing services.