Patents by Inventor Jason S Sawyer

Jason S Sawyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carboline derivatives
    Patent number: 7122554
    Abstract: Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: October 17, 2006
    Assignee: Lilly Icos LLC.
    Inventors: Jason S. Sawyer, Mark W. Orme, Raymond F. Brown, Alain C. Daugan, Agnes Bombrun
  • Chemical compounds
    Patent number: 7115621
    Abstract: Compounds of general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents as inhibitors of phosphodiesterase 5 cardiovascular disorders
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: October 3, 2006
    Assignee: Lilly Icos LLC
    Inventors: Jason S. Sawyer, Mark W. Orme, James D. Copp
  • Tetracyclic compounds as PDE5-inhibitors
    Patent number: 7105506
    Abstract: Compounds of structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: September 12, 2006
    Assignee: Lilly Icos LLC
    Inventors: Mark W. Orme, Jason S. Sawyer, Lisa M. Schultze
  • Pyrazino [1'2':1,6 ] pyrido [3, 4-b] indole-1,4-dione derivatives
    Patent number: 7098209
    Abstract: Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as thereapeutic agents.
    Type: Grant
    Filed: April 15, 2002
    Date of Patent: August 29, 2006
    Assignee: Lilly Icos LLC
    Inventors: Mark W. Orme, Jason S. Sawyer, Lisa M. Schultze
  • Carboline derivatives
    Patent number: 7022856
    Abstract: Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: December 18, 2001
    Date of Patent: April 4, 2006
    Assignee: LIlly Icos LLC.
    Inventors: Mark W. Orme, Jason S. Sawyer, Agnes Bombrun, Romain L. Gosmini, Anne Bouillot, Nerina Dodic, Michael Sierra
  • Carboline derivatives as PDE5 inhibitors
    Patent number: 6992192
    Abstract: Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: January 31, 2006
    Assignee: Lilly Icos LLC.
    Inventors: Jason S. Sawyer, Mark W. Orme
  • Carboline derivatives as PDE5 inhibitors
    Patent number: 6984641
    Abstract: Selective inhibitors of cGMP-specific PDE, and use of the compounds and salts and solvates thereof as therapeutic agents, are disclosed.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: January 10, 2006
    Assignee: Lilly Icos LLC.
    Inventors: Mark W. Orme, Jason S. Sawyer, Alain C. Daugan, Agnes Bombrun, Françoise Gellibert, Lisa M. Schultze, Raymond F. Brown, Romain L. Gosmini
  • Carboline derivatives as pdev inhibitors
    Publication number: 20040171830
    Abstract: Selective inhibitors of cGMP-specific PDE, and use of the compounds and salts and solvates thereof as therapeutic agents, are disclosed.
    Type: Application
    Filed: November 25, 2003
    Publication date: September 2, 2004
    Inventors: Mark W Orme, Jason S Sawyer, Alain C Daugan, Agnes Bombrun, Francois Gellibert, Lisa M Schultze, Raymond E Brown, Romain L Gosmini
  • Tetracyclic compounds as pde5-inhibitors
    Publication number: 20040162291
    Abstract: Compounds of structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Application
    Filed: November 25, 2003
    Publication date: August 19, 2004
    Inventors: Mark W. Orme, Jason S. Sawyer, Lisa M. Schultze
  • Pyrazino 1',2':1,6 pyrido 3,4-b indole1,4-dione derivatives
    Publication number: 20040152705
    Abstract: Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as thereapeutic agents. In particular, the invention relates to compounds that are potent and selective inhibitors of cyclic guanosine 3′, 5′-monophosphate specific phosphodiesterase (cGMP-specific PDE), in particular PDE5, and have utility in a variety of therapeutic areas wherein such inhibition is considered beneficial, including the treatment of cardiovascular disorders and erectile dysfunction.
    Type: Application
    Filed: November 24, 2003
    Publication date: August 5, 2004
    Inventors: Mark W. Orme, Jason S. Sawyer, Lisa M. Schultze
  • Chemical compounds
    Publication number: 20040147542
    Abstract: Compounds of general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents as inhibitors of phosphodiesterase 5 cardiovascular disorders.
    Type: Application
    Filed: February 9, 2004
    Publication date: July 29, 2004
    Inventors: Jason S. Sawyer, Mark W. Orme, James D. Copp
  • Chemical compounds
    Publication number: 20040122035
    Abstract: Compounds of the general structural formula 1
    Type: Application
    Filed: February 12, 2004
    Publication date: June 24, 2004
    Inventors: Mark W. Orme, Jason S Sawyer, Agnes Bombrun, Romain L Gosmini, Anne Bouillot, Nerina Dodic, Michael Sierra
  • Chemical compounds
    Publication number: 20040116458
    Abstract: Compounds of the general structural formula 1
    Type: Application
    Filed: January 8, 2004
    Publication date: June 17, 2004
    Inventors: Jason S. Sawyer, Mark W Orme, Raymond F Brown, Alain C Daugan, Agnes Bombrun
  • Method of treating gout with certain indole compounds
    Patent number: 6303610
    Abstract: This invention relates to a method of treating gout with certain indole compounds and other aromatic compounds.
    Type: Grant
    Filed: March 6, 2000
    Date of Patent: October 16, 2001
    Assignee: Eli Lilly and Company
    Inventors: Douglas W Johnson, John M Morin, Jr., Jason S Sawyer, Robert T Shuman
  • N,N-diethylglycolamido ester prodrugs of indole sPLA2 inhibitors
    Patent number: 6274616
    Abstract: The compound, ((3-(2-amino-1,2-dioxoethyl)-1-((1,1′-biphenyl-3-ylmethyl)-2-methyl-1H-indol-4-yl)oxy)acetic acid N,N-diethylglycolamido ester, is disclosed together with its use as a highly bioavailable indole compound for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
    Type: Grant
    Filed: March 29, 2000
    Date of Patent: August 14, 2001
    Assignee: Eli Lilly and Company
    Inventors: Michael L Denney, John M Morin, Jr., Daniel J Sall, Jason S Sawyer
  • Morpholino-N-ethyl ester prodrugs of indole sPLA2 inhibitors
    Patent number: 6177426
    Abstract: The compound, ((3(2-amino-1,2-dioxoethyl)-1-((1,1′-biphenyl)-3-ylmethyl)-2-methyl-1H-indol-4-yl)oxy)acetic acid morpholino-ethyl ester, is disclosed together with its use as a highly bioavailable indole compound for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
    Type: Grant
    Filed: March 29, 2000
    Date of Patent: January 23, 2001
    Assignee: Eli Lilly and Company
    Inventors: Michael L Denney, John M Morin, Daniel J Sall, Jason S Sawyer
  • Leukotriene antagonists useful for treating iritis
    Patent number: 5998454
    Abstract: This invention provides methods for the treatment or inhibiting of iritis which comprises administering to a mammal in need thereof an effective amount of a compound having activity as a leukotriene B.sub.4 antagonist.
    Type: Grant
    Filed: March 13, 1998
    Date of Patent: December 7, 1999
    Assignee: Eli Lilly and Company
    Inventors: Jerome H. Fleisch, William T. Jackson, Jason S. Sawyer
  • Leukotriene antagonists useful for treating dermatoses
    Patent number: 5914340
    Abstract: This invention provides methods for the treatment or inhibiting of dermatitis which comprises administering to a mammal in need thereof an effective amount of a compound having activity as a leukotriene B.sub.4 antagonist.
    Type: Grant
    Filed: March 13, 1998
    Date of Patent: June 22, 1999
    Assignee: Eli Lilly and Company
    Inventors: Jerome H. Fleisch, William T. Jackson, Jason S. Sawyer
  • Leukotriene antagonists for use in the treatment or inhibition of oral squamous cell carcinoma
    Patent number: 5910505
    Abstract: This invention provides methods for the treatment or inhibitor of oral squamous cell carcinoma which comprises administering to a mammal in need thereof an effective amount of a compound having activity as a leukotriene B.sub.4 antagonist.
    Type: Grant
    Filed: December 2, 1997
    Date of Patent: June 8, 1999
    Assignee: Eli Lilly and Company
    Inventors: Jerome H. Fleisch, William T. Jackson, Jason S. Sawyer
  • Leukotriene antagonists for use in the treatment or inhibition of cerebral focal stroke
    Patent number: 5817684
    Abstract: This invention provides methods for the treatment or prevention of cerebral focal ischemia which comprises administering to a mammal in need thereof an effective amount of a compound having activity as a leukotriene B.sub.4 antagonist.
    Type: Grant
    Filed: December 2, 1997
    Date of Patent: October 6, 1998
    Assignee: Eli Lilly and Company
    Inventors: Jerome H. Fleisch, William T. Jackson, Jason S. Sawyer