Patents by Inventor Jason Shaoyun Xiang

Jason Shaoyun Xiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses thereof
    Patent number: 10449258
    Abstract: Disclosed are an antibody drug conjugate IB, which uses ether linkages for connection, and improves the water solubility, stability and cytotoxicity in vivo and in intro, and an intermediate, a pharmaceutical composition, and uses of the antibody drug conjugate. The antibody drug conjugate has simple synthetic steps and a high yield.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: October 22, 2019
    Assignee: XDCEXPLORER (SHANGHAI) CO., LTD.
    Inventors: Jason Shaoyun Xiang, Shifeng Liu, Hongyu Yang, Xingquan Ma
  • NOVEL HETEROCYCLIC COMPOUNDS AS INHIBITORS OF VANIN-1 ENZYME
    Publication number: 20190292157
    Abstract: Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
    Type: Application
    Filed: April 10, 2019
    Publication date: September 26, 2019
    Applicant: Pfizer Inc.
    Inventors: Agustin Casimiro-Garcia, Jeffrey Scott Condon, Andrew Christopher Flick, Ariamala Gopalsamy, Steven J. Kirincich, John Paul Mathias, Joseph Walter Strohbach, Jason Shaoyun Xiang, Li Huang Xing, Xiaolun Wang
  • Heterocyclic compounds as inhibitors of Vanin-1 enzyme
    Patent number: 10308615
    Abstract: Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: June 4, 2019
    Assignee: Pfizer Inc.
    Inventors: Agustin Casimiro-Garcia, Jeffrey Scott Condon, Andrew Christopher Flick, Ariamala Gopalsamy, Steven J. Kirincich, John Paul Mathias, Joseph Walter Strobach, Jason Shaoyun Xiang, Li Huang Xing, Xiaolun Wang
  • ANTIBODY DRUG CONJUGATE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF
    Publication number: 20180161446
    Abstract: Disclosed are an antibody drug conjugate IB, which uses ether linkages for connection, and improves the water solubility, stability and cytotoxicity in vivo and in intro, and an intermediate, a pharmaceutical composition, and uses of the antibody drug conjugate. The antibody drug conjugate has simple synthetic steps and a high yield.
    Type: Application
    Filed: June 8, 2016
    Publication date: June 14, 2018
    Applicant: XDCEXPLORER (SHANGHAI) CO., LTD.
    Inventors: Jason Shaoyun XIANG, Shifeng LIU, Hongyu YANG, Xingquan MA
  • NOVEL HETEROCYCLIC COMPOUNDS AS INHIBITORS OF VANIN-1 ENZYME
    Publication number: 20180148420
    Abstract: Compounds, pharmaceutically acceptable salts thereof are disclosed wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
    Type: Application
    Filed: May 16, 2016
    Publication date: May 31, 2018
    Applicant: Pfizer Inc.
    Inventors: Agustin Casimiro-Garcia, Jeffrey Scott Condon, Andrew Christopher Flick, Ariamala Gopalsamy, Steven J. Kirincich, John Paul Mathias, Joseph Walter Strobach, Jason Shaoyun Xiang, Li Huang Xing, Xiaolun Wang
  • Glutamate aggrecanase inhibitors
    Patent number: 7998965
    Abstract: The present invention relates to modulators of metalloproteinase activity.
    Type: Grant
    Filed: May 14, 2009
    Date of Patent: August 16, 2011
    Assignee: Wyeth LLC
    Inventors: Phaik-Eng Sum, Jerauld Stanley Skotnicki, Steve Yik-Kai Tam, Tarek Suhayl Mansour, David Brian How, Joshua James Sabatini, Jason Shaoyun Xiang, Eric Feyfant
  • Biaryl sulfonamides and methods for using same
    Patent number: 7923446
    Abstract: The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
    Type: Grant
    Filed: May 31, 2007
    Date of Patent: April 12, 2011
    Assignee: Wyeth LLC
    Inventors: Jason Shaoyun Xiang, Steve Yikkai Tam, Yonghan Hu, Phaik-Eng Sum, David Brian How, Darrin William Hopper, Matthew Douglas Vera, Joshua James Sabatini, Thomas Saltmarsh Rush, III, Elisabeth Ann Morris, Katy Evangelia Georgiadis
  • Biaryl Sulfonamides and Methods for Using Same
    Publication number: 20100137298
    Abstract: The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
    Type: Application
    Filed: June 13, 2008
    Publication date: June 3, 2010
    Applicant: Wyeth
    Inventors: Jeremy Ian Levin, Thomas Saltmarsh Rush, III, Frank Lovering, Yonghan Hu, Jianchang Li, Wei Li, Jun Jun Wu, Rajeev Hotchandani, Jason Shaoyun Xiang, Xuemei Du, Derek Cecil Cole, Steve Yikkai Tam
  • 11-Beta HSD1 Inhibitors
    Publication number: 20100029648
    Abstract: This invention relates to inhibiting 11?HSD1.
    Type: Application
    Filed: August 11, 2009
    Publication date: February 4, 2010
    Inventors: Jason Shaoyun Xiang, Eddine Saiah, Steve Y. Tam, John C. McKew, Lihren Chen, Manus Ipek, Katherine Lee, Huan-Qiu Li, Jianchang Li, Wei Li, Tarek Suhayl Mansour, Vipin Suri, Richard Vargas, Yuchuan Wu, Zhao-Kui Wan, Jinbo Lee, Eva Binnun, Douglas P. Wilson
  • GLUTAMATE AGGRECANASE INHIBITORS
    Publication number: 20100010012
    Abstract: The present invention relates to modulators of metalloproteinase activity.
    Type: Application
    Filed: May 14, 2009
    Publication date: January 14, 2010
    Applicant: Wyeth
    Inventors: Phaik-Eng Sum, Jerauld Stanley Skotnicki, Steve Yik-Kai Tam, Tarek Suhayl Mansour, David Brian How, Joshua James Sabatini, Jason Shaoyun Xiang, Eric Feyfant
  • 11-beta HSD1 inhibitors
    Patent number: 7632838
    Abstract: This invention relates to inhibiting 11?HSD1.
    Type: Grant
    Filed: February 7, 2007
    Date of Patent: December 15, 2009
    Assignee: Wyeth
    Inventors: Jason Shaoyun Xiang, Eddine Saiah, Steve Y. Tam, John C. Mckew, Lihren Chen, Manus Ipek, Huan-Qiu Li, Jianchang Li, Wei Li, Tarek Suhayl Mansour, Vipin Suri, Yuchuan Wu, Zhao-Kui Wan, Jinbo Lee, Eva Binnun, Douglas P. Wilson
  • Glutamate aggrecanase inhibitors
    Patent number: 7553873
    Abstract: The present invention relates to modulators of metalloproteinase activity.
    Type: Grant
    Filed: July 11, 2006
    Date of Patent: June 30, 2009
    Assignee: Wyeth
    Inventors: Phaik-Eng Sum, Jerauld Stanley Skotnicki, Steve Yik-Kai Tam, Tarek Suhayl Mansour, David Brian How, Joshua James Sabatini, Jason Shaoyun Xiang, Eric Feyfant
  • METHOD FOR TREATING ADAMTS-5-ASSOCIATED DISEASE
    Publication number: 20080311113
    Abstract: The present invention relates to methods of treating ADAMTS-5-associated diseases and particularly osteoarthritis comprising administering an agent capable of modulating ADMATS-5 activity to a subject afflicted with the disease. The agent is preferably a biaryl sulfonamide compound. The invention is based, in part, on the discovery that transgenic animals that do not express functional ADAMTS-5 show a reduction in the degree of osteoarthritis after the induction of osteoarthritis as compared to WT animals. Furthermore, the ADAMTS-5 transgenic animals have reduced aggrecanase activity in articular tissue as compared to WT animals. These animals are good models for ADAMTS-5-associated diseases, and for screening of drugs useful in the treatment and/or prevention of these diseases. There are no other animal models in which the deletion of the activity of a single gene is capable of abrogating the course of osteoarthritis.
    Type: Application
    Filed: May 20, 2008
    Publication date: December 18, 2008
    Applicant: Wyeth
    Inventors: Elisabeth A. Morris, Sonya Glasson, Jason Shaoyun Xiang
  • Biaryl sulfonamides and methods for using same
    Patent number: 7420001
    Abstract: The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
    Type: Grant
    Filed: December 1, 2004
    Date of Patent: September 2, 2008
    Assignee: Wyeth
    Inventors: Jeremy Ian Levin, Thomas Saltmarsh Rush, III, Frank Lovering, Yonghan Hu, Jianchang Li, Wei Li, Jun Jun Wu, Rajeev Hotchandani, Jason Shaoyun Xiang, Xuemei Du, Derek Cecil Cole, Steve Yikkai Tam
  • Method for treating ADAMTS-5-associated disease
    Patent number: 7390833
    Abstract: The present invention relates to methods of treating ADAMTS-5-associated diseases and particularly osteoarthritis comprising administering an agent capable of modulating ADMATS-5 activity to a subject afflicted with the disease. The agent is preferably a biaryl sulfonamide compound. The invention is based, in part, on the discovery that transgenic animals that do not express functional ADAMTS-5 show a reduction in the degree of osteoarthritis after the induction of osteoarthritis as compared to WT animals. Furthermore, the ADAMTS-5 transgenic animals have reduced aggrecanase activity in articular tissue as compared to WT animals. These animals are good models for ADAMTS-5-associated diseases, and for screening of drugs useful in the treatment and/or prevention of these diseases. There are no other animal models in which the deletion of the activity of a single gene is capable of abrogating the course of osteoarthritis.
    Type: Grant
    Filed: November 8, 2004
    Date of Patent: June 24, 2008
    Assignee: Wyeth
    Inventors: Elisabeth A. Morris, Sonya Glasson, Jason Shaoyun Xiang
  • Biaryl sulfonamides and methods for using same
    Patent number: 7268135
    Abstract: The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
    Type: Grant
    Filed: December 1, 2004
    Date of Patent: September 11, 2007
    Assignee: Wyeth
    Inventors: Jason Shaoyun Xiang, Steve Yikkai Tam, Yonghan Hu, Phaik-Eng Sum, David Brian How, Darrin William Hopper, Matthew Douglas Vera, Joshua James Sabatini, Thomas Saltmarsh Rush, III
  • Dihydrodipyrazolopyridinone inhibitors of B7-1
    Patent number: 6900223
    Abstract: The present invention provides a compound of formula I and the use thereof for the immunotherapeutic treatment of transplant rejection, autoimmune disease or graft vs. host disease.
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: May 31, 2005
    Assignee: Wyeth
    Inventors: Neal Jeffrey Green, Steve Yikkai Tam, Jason Shaoyun Xiang, Audrey Molina Davies, Lihren Chen, Gary Paul Stack
  • Dihydrodipyrazolopyridinylbenzamide and -sulfonamide inhibitors of B7-1
    Patent number: 6734190
    Abstract: The present invention provides a compound of formula I and the use thereof for the immunotherapeutic treatment of transplant rejection or autoimmune disease.
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: May 11, 2004
    Assignee: Wyeth
    Inventors: Neal Jeffrey Green, Jason Shaoyun Xiang, Audrey Molina Davies, Lihren Chen
  • Dihydrodipyrazolopyridinone inhibitors of B7-1
    Publication number: 20040044024
    Abstract: The present invention provides a compound of formula I and the use thereof for the immunotherapeutic treatment of transplant rejection, autoimmune disease or graft vs. host disease.
    Type: Application
    Filed: July 28, 2003
    Publication date: March 4, 2004
    Applicant: Wyeth
    Inventors: Neal Jeffrey Green, Steve Yikkai Tam, Jason Shaoyun Xiang, Audrey Molina Davies, Lihren Chen, Gary Paul Stack
  • Dihydrodipyrazolopyridinylbenzamide and -sulfonamide inhibitors of B7-1
    Publication number: 20040024008
    Abstract: The present invention provides a compound of formula I and the use thereof for the immunotherapeutic treatment of transplant rejection or autoimmune disease.
    Type: Application
    Filed: July 28, 2003
    Publication date: February 5, 2004
    Applicant: Wyeth
    Inventors: Neal Jeffrey Green, Jason Shaoyun Xiang, Audrey Molina Davies, Lihren Chen