Abstract: Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. The cannula is shaped to facilitate insertion thereof into a patient's eyeball.

Abstract: Elastomeric check valves for use, e.g., in small pump devices, may include a molded elastomeric valve body forming a pocket that extends from an opening at the valve inlet to a terminus inside the valve body, and having a slit extending from the terminus to a valve outlet.

Abstract: In various embodiments, actuation of a drug-delivery pump is controlled based on a change in a condition of the pump.

Abstract: Embodiments of method of manufacturing an implantable pump, including providing an upper layer comprising a dome structure for housing a drug chamber and a cannula in fluid communication with the drug chamber, providing a middle deflection layer adjacent the drug chamber, providing a bottom layer comprising electrolysis electrodes, and bonding the upper layer, middle deflection layer, and bottom layer to form the pump.

Abstract: Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. When a predetermined cracking pressure is reached, a valve opens and allows the liquid to flow through the cannula.

Abstract: In various embodiments, actuation of a drug-delivery pump is controlled based on a change in a condition of the pump.

Abstract: In various embodiments, a tool is employed in filling a drug-delivery device. The tool may include, for example, a needle that is admitted through a fill port of the drug-delivery device.

Abstract: Embodiments of an implantable electrolytic pump include a drug reservoir, a cannula fluidly coupled to the reservoir, a pumping mechanism for forcing liquid from the reservoir through the cannula, control circuitry for operating the pumping mechanism, and a power source comprising primary and auxiliary batteries in a stacked configuration, only the main battery being operatively coupled to the control circuitry during normal operation, the control circuitry operatively coupling the back-up battery upon detection of an electrical fault. The pump may further include a hermetic enclosure containing the control circuitry and the power source.

Abstract: The present invention relates to tackifier compounds and methods of using the same. In various embodiments, the present invention provides a tackifier compound including independently substituted or unsubstituted fused rings A and B each independently chosen from (C5-C10)cycloalkyl and (C2-C10)heterocyclyl. Fused ring A is substituted with (R1)1-8 and fused ring B is substituted with —(OC(O)R?C(O)R2)1-8. At each occurrence R? is independently chosen from (C2-C10)alkanylene, (C2-C10)alkenylene, (C2-C10)alkynylene, C5-C20(arylene), and (C1-C20)heteroarylene, wherein R? is unsubstituted or substituted. At each occurrence R1 is independently selected from —OH, —OR3, and —OC(O)R?C(O)R2. At each occurrence R2 is independently chosen from —OH, —OR3, —NH2, —NHR3, and —NR32. At each occurrence R3 is independently chosen from (C1-C10)alkanyl, (C2-C10)alkenyl, (C2-C10)alkynyl, C5-C20(aryl), and (C1-C20)heteroaryl, wherein R3 is unsubstituted or substituted.

Abstract: The present invention is directed to polyisocyanates and polyurethanes derived therefrom. In various embodiments, the present invention provides polyisocyanates, methods of making the polyisocyanates from fused bicyclic alcohols, polyurethanes, and methods of making the polyurethanes from the polyisocyanates.

Abstract: A method and system for controlling an NFC device are provided, the NFC device comprising an NFC module for establishing an NFC connection with an NFC chip, and a network module for establishing a network connection with a cloud infrastructure, the method comprising: establishing an NFC connection between the NFC chip and the NFC device; receiving a unique reference identification (URI) of the NFC chip by an app configured to process the URI; establishing a network connection between the app and the cloud infrastructure; transmitting the URI to the cloud infrastructure; receiving NFC data associated with the URI from the cloud infrastructure; and executing the app in accordance with the NFC data.

Abstract: A method and system for managing product information is provided, the method comprising: establishing an NFC communication between an NFC chip imbedded in an NFC product and an NFC device; receiving a unique reference identification (URI) for the NFC product from the NFC chip; collecting location data of the NFC device; associating the URI with the location data; and transmitting the URI and the associated location data to a cloud infrastructure.

Abstract: Embodiments of method of manufacturing an implantable pump, including providing an upper layer comprising a dome structure for housing a drug chamber and a cannula in fluid communication with the drug chamber, providing a middle deflection layer adjacent the drug chamber, providing a bottom layer comprising electrolysis electrodes, and bonding the upper layer, middle deflection layer, and bottom layer to form the pump.

Abstract: An adjustable bicycle carrier contains a base; a first mounting rack including an inner rod and an outer rod, and the inner rod having a retaining seat; a rotatable adjusting device including a rotating member a pawl wheel, a rotatable adjustment knob partially, a steel cable and a first resilient element. The steel cable has a first end disposed on an inner peripheral side of the inner rod and a second end mounted on the rotating member. The adjustable bicycle carrier also contains a locking device including a swing arm, and the swing arm having a fixing mount secured on a predetermined portion thereof, wherein the positioning block and the fixing mount simultaneously swing with the swing arm, the fixing mount has a teeth portion for engaging with the pawl wheel, such that when the swing arm swings, the pawl wheel engages with or disengages from the toothed portion.

Abstract: Excess gas generated by and within electrolytic drug-pump devices is managed by strategically facilitating catalytic recombination or sequestration of excess electrolysis gases in void regions where such gases are most likely to accumulate.

Abstract: An adjustable bicycle carrier contains a base; a first mounting rack including an inner rod and an outer rod, and the inner rod having a retaining seat; a rotatable adjusting device including a rotating member a pawl wheel, a rotatable adjustment knob partially, a steel cable and a first resilient element. The steel cable has a first end disposed on an inner peripheral side of the inner rod and a second end mounted on the rotating member. The adjustable bicycle carrier also contains a locking device including a swing arm, and the swing arm having a fixing mount secured on a predetermined portion thereof, wherein the positioning block and the fixing mount simultaneously swing with the swing arm, the fixing mount has a teeth portion for engaging with the pawl wheel, such that when the swing arm swings, the pawl wheel engages with or disengages from the toothed portion.

Abstract: Embodiments of the present invention involve a refill apparatus comprising at least one pump, a plurality of reservoirs, a plurality of reservoir fluid channels each associated with one of the reservoirs, a plurality of valves, each having a cracking pressure, for fluidically sealing the reservoir fluid channels and the outlet fluid channel, an outlet fluid channel fluidically connected to the reservoir fluid channels, and a needle having a lumen in fluid communication with the outlet fluid channel. A parameter such as a pressure level is monitored, and one or more pumps and various ones of the valves are actuated in accordance with a protocol comprising a sequence of steps whereby fluidic pathways are opened between different ones of the reservoirs and the needle in a washing and filling sequence, each of the steps being associated with an expected pressure level.

Abstract: In various embodiments, a tool is employed in filling a drug-delivery device. The tool may include, for example, a needle that is admitted through a fill port of the drug-delivery device.

Abstract: A removable material is deposited or otherwise applied to a flat substrate surface in a pattern corresponding to desired corrugations in a membrane, e.g., a deflection diaphragm. The applied material serves as a scaffold for a polymeric material, which is applied thereover, and following cure or hardening, the polymeric material is removed to form a finished corrugated membrane.

Abstract: A recombination mask integrated onto an electrolysis chip tunes electrolysis parameters by masking off portions of the electrodes exposed to an electrolyte solution. This prevents electrolysis gases from reaching the catalyst on the electrodes and recombining.