Patents by Inventor Jason T. LOWE

Jason T. LOWE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CERTAIN PLADIENOLIDE COMPOUNDS AND METHODS OF USE
    Publication number: 20240368140
    Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.
    Type: Application
    Filed: February 20, 2024
    Publication date: November 7, 2024
    Applicant: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Gregg F. KEANEY, John WANG, Baudouin GERARD, Kenzo ARAI, Xiang LIU, Guo Zhu ZHENG, Kazunobu KIRA, Lisa A. MARCAURELLE, Marta NEVALAINEN, Ming-Hong HAO, Morgan Welzel O'SHEA, Parcharee TIVITMAHAISOON, Sudeep PRAJAPATI, Tuoping LUO, Nicholas C. GEARHART, Jason T. LOWE, Yoshihiko KOTAKE, Satoshi NAGAO, Regina Mikie KANADA SONOBE, Masayuki MIYANO, Norio MURAI, Andrew COOK, Shelby ELLERY, Atsushi ENDO, James PALACINO, Dominic REYNOLDS
  • COMPOUNDS AND USES THEREOF
    Publication number: 20240166668
    Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.
    Type: Application
    Filed: November 27, 2023
    Publication date: May 23, 2024
    Inventors: Sabine K. RUPPEL, Zhaoxia Yang, Jason T. LOWE, Johannes H. VOIGT
  • BRD9 DEGRADERS AND USES THEREOF
    Publication number: 20240150348
    Abstract: The present invention relates to methods and compositions for the treatment of BAF-related disorders such as cancers and viral infections.
    Type: Application
    Filed: August 25, 2023
    Publication date: May 9, 2024
    Inventors: Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Johannes H. VOIGT, Matthew NETHERTON, Francois BRUCELLE
  • METHODS AND COMPOUNDS FOR TREATING DISORDERS
    Publication number: 20240150328
    Abstract: The present invention relates to methods and compositions for the treatment of BAF-related disorders such as cancers and viral infections.
    Type: Application
    Filed: August 23, 2023
    Publication date: May 9, 2024
    Inventors: Qianhe ZHOU, Michael BOCKER, David Simon MILLAN, Ho Man CHAN, Luis SOARES, Matthew NETHERTON, Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Francois BRUCELLE
  • COMPOUNDS AND USES THEREOF
    Publication number: 20240067642
    Abstract: The present invention relates to compositions and methods for the treatment of BAF-related disorders, such as cancers and viral infections.
    Type: Application
    Filed: June 29, 2023
    Publication date: February 29, 2024
    Inventors: Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Johannes H. VOIGT, Matthew NETHERTON
  • COMPOUNDS AND USES THEREOF
    Publication number: 20240002382
    Abstract: The present invention relates to compositions and methods for the treatment of BAF-related disorders, such as cancers and viral infections.
    Type: Application
    Filed: June 29, 2023
    Publication date: January 4, 2024
    Inventors: Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Johannes H. VOIGT, Matthew NETHERTON
  • COMPOUNDS AND USES THEREOF
    Publication number: 20230416246
    Abstract: The present invention relates to compositions and methods for the treatment of BAF-related disorders, such as cancers and viral infections.
    Type: Application
    Filed: June 29, 2023
    Publication date: December 28, 2023
    Inventors: Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Johannes H. VOIGT, Matthew NETHERTON
  • COMPOUNDS AND USES THEREOF
    Publication number: 20230331722
    Abstract: The present invention relates to compositions and methods for the treatment of BAF-related disorders, such as cancers and viral infections.
    Type: Application
    Filed: June 29, 2023
    Publication date: October 19, 2023
    Inventors: Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Johannes H. VOIGT, Matthew NETHERTON
  • CERTAIN ARYL PLADIENOLIDE COMPOUNDS AND METHODS OF USE
    Publication number: 20230301990
    Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.
    Type: Application
    Filed: March 7, 2023
    Publication date: September 28, 2023
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Andrew COOK, Dominic REYNOLDS, Cheng ZHONG, Ryan BRAWN, Shelby ELLERY, Thiwanka SAMARAKOON, Xiang LIU, Sudeep PRAJAPATI, Megan SHEEHAN, Jason T. LOWE, James PALACINO
  • COMPOUNDS AND USES THEREOF
    Publication number: 20230077730
    Abstract: The present invention relates to methods and compositions for the treatment of BAF-related disorders such as cancers and viral infections.
    Type: Application
    Filed: January 29, 2020
    Publication date: March 16, 2023
    Applicants: Foghorn Therapeutics Inc., Foghorn Therapeutics Inc.
    Inventors: Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Johannes H. VOIGT, Matthew NETHERTON, Francois BRUCELLE
  • COMPOUNDS AND USES THEREOF
    Publication number: 20230072053
    Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.
    Type: Application
    Filed: January 29, 2021
    Publication date: March 9, 2023
    Inventors: Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Johannes H. VOIGT
  • COMPOUNDS AND USES THEREOF
    Publication number: 20230065463
    Abstract: The present invention relates to compositions and methods for the treatment of BAF-related disorders, such as cancers and viral infections.
    Type: Application
    Filed: January 29, 2020
    Publication date: March 2, 2023
    Inventors: Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Johannes H. VOIGT, Matthew NETHERTON, Francois BRUCELLE
  • COMPOUNDS AND USES THEREOF
    Publication number: 20230066136
    Abstract: The present invention relates to compositions and methods for the treatment of BAF-related disorders, such as cancers and viral infections.
    Type: Application
    Filed: January 29, 2020
    Publication date: March 2, 2023
    Inventors: Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Johannes H. VOIGT, Matthew NETHERTON
  • COMPOUNDS AND USES THEREOF
    Publication number: 20220289711
    Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.
    Type: Application
    Filed: July 31, 2020
    Publication date: September 15, 2022
    Inventors: Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE
  • COMPOUNDS AND USES THEREOF
    Publication number: 20220098190
    Abstract: The present invention relates to compositions and methods for the treatment of BAF-related disorders, such as cancers and viral infections.
    Type: Application
    Filed: January 29, 2020
    Publication date: March 31, 2022
    Inventors: Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Johannes H. VOIGT, Matthew NETHERTON, Francois BRUCELLE, Rishi G. VASWANI
  • COMPOUNDS AND USES THEREOF
    Publication number: 20220048906
    Abstract: The present invention relates to methods and compositions for the treatment of BAF-related disorders such as cancers and viral infections.
    Type: Application
    Filed: July 22, 2021
    Publication date: February 17, 2022
    Inventors: Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Johannes H. VOIGT, Matthew NETHERTON, Francois BRUCELLE
  • COMPOUNDS AND USES THEREOF
    Publication number: 20210230190
    Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.
    Type: Application
    Filed: January 29, 2021
    Publication date: July 29, 2021
    Inventors: Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Johannes H. VOIGT
  • CERTAIN ARYL PLADIENOLIDE COMPOUNDS AND METHODS OF USE
    Publication number: 20210177837
    Abstract: The present disclosure provides pladienolide compounds, pharmaceutical compositions containing such compounds, and pladienolide compounds for use in methods of medical treatment. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are pladienolide compounds for use in methods of treating cancers by administering at least one pladienolide compound disclosed herein and at least one additional therapy.
    Type: Application
    Filed: April 11, 2019
    Publication date: June 17, 2021
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Andrew COOK, Dominic REYNOLDS, Cheng ZHONG, Ryan BRAWN, Shelby ELLERY, Thiwanka SAMARAKOON, Xiang LIU, Sudeep PRAJAPATI, Megan SHEEHAN, Jason T. LOWE, James PALACINO
  • CERTAIN PLADIENOLIDE COMPOUNDS AND METHODS OF USE
    Publication number: 20210163456
    Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.
    Type: Application
    Filed: April 8, 2019
    Publication date: June 3, 2021
    Applicant: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Gregg F. KEANEY, John WANG, Baudouin GERARD, Kenzo ARAI, Xiang LIU, Guo Zhu ZHENG, Kazunobu KIRA, Lisa A. MARCAURELLE, Marta NEVALAINEN, Ming-Hong HAO, Morgan Welzel O'SHEA, Parcharee TIVITMAHAISOON, Sudeep PRAJAPATI, Touping LUO, Nicholas C. GEARHART, Jason T. LOWE, Yoshihiko KOTAKE, Satoshi NAGAO, Regina Mikie KANADA SONOBE, Masayuki MIYANO, Norio MURAI, Andrew COOK, Shelby ELLERY, Atsushi ENDO, James PALACINO, Dominic REYNOLDS
  • COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF
    Publication number: 20200197391
    Abstract: The disclosure features macrocyclic compounds, alone and in combination with other therapeutic agents, as well as pharmaceutical compositions and protein complexes thereof, capable of modulating biological processes including RAS and RAS-RAF inhibition, and their uses in the treatment of cancers.
    Type: Application
    Filed: December 20, 2019
    Publication date: June 25, 2020
    Inventors: Meizhong JIN, Nicholas PERL, Anna KOHLMANN, Ning YIN, Jason T. LOWE, Jae Young AHN, Mark Joseph MULVIHILL, Elena S. KOLTUN, Adrian L. GILL