Abstract: The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

Abstract: The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R7, and R8 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compound, and methods of using the Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

Abstract: Provided herein are improved methods of determining the sequences of cell-free DNA (cfDNA). The methods in certain embodiments are used for the analysis of circulating DNA in serum samples, such as circulating fetal DNA, circulating donor derived DNA, or circulating tumor DNA. In certain embodiments, the methods include selectively enriching trinucleosomal, dinucleosomal, mononucleosomal or sub-mononucleosomal DNA from the isolated cfDNA.

Abstract: Disclosed here is a composition for isolating nucleic acids from a biological sample, comprising a chaotropic compound and a solvent, wherein the solvent comprises a nitrile compound, tetrahydrofuran, or a combination thereof. Also disclosed is a method for binding nucleic acids to a matrix, comprising: contacting the nucleic acids from a biological sample with the matrix in the presence of a chaotropic compound and a solvent, wherein the solvent comprises a nitrile compound, tetrahydrofuran, or a combination thereof, thereby binding the nucleic acids to the matrix. Further disclosed is a kit for isolating nucleic acids from a biological sample comprising a binding buffer, wherein the binding buffer comprises a chaotropic compound and a solvent, wherein the solvent comprises a nitrile compound, tetrahydrofuran, or a combination thereof.

Abstract: Disclosed here is a method for isolating nucleic acids from a biological sample, comprising: (a) contacting a first composition comprising nucleic acids obtained from a biological sample with a first matrix under a low-stringency binding condition having less than 1% aliphatic alcohols that binds less than 5% of nucleic acids of shorter than about 118 bp and more than 30% of nucleic acids longer than about 194 bp to a first matrix; and (b) contacting a second composition comprising remainder of the first composition with a second matrix under a high-stringency binding condition having less than 1% aliphatic alcohol that binds more than 70% of nucleic acids longer than about 72 bp and 30% of nucleic acids longer than about 50 bp to the second matrix.

Abstract: Disclosed here is a composition for isolating nucleic acids from a biological sample, comprising a chaotropic compound and a solvent, wherein the solvent comprises a nitrile compound, tetrahydrofuran, or a combination thereof. Also disclosed is a method for binding nucleic acids to a matrix, comprising: contacting the nucleic acids from a biological sample with the matrix in the presence of a chaotropic compound and a solvent, wherein the solvent comprises a nitrile compound, tetrahydrofuran, or a combination thereof, thereby binding the nucleic acids to the matrix. Further disclosed is a kit for isolating nucleic acids from a biological sample comprising a binding buffer, wherein the binding buffer comprises a chaotropic compound and a solvent, wherein the solvent comprises a nitrile compound, tetrahydrofuran, or a combination thereof.

Abstract: A system, apparatus and method for saliva-conductance based hydration sensors and for a wireless network comprising hydration sensors and base stations. The hydration sensors include electrodes, a means of measuring saliva conductance, a processor, memory and wireless controllers. The hydration sensors output user hydration status based on the conductance of the user's saliva. Saliva conductance is correlated with ion concentration of saliva, which is a biomarker for dehydration. Thus, saliva conductance can be a proxy for dehydration. The hydration sensors may be used in active or hostile conditions, e.g., military use. Symptoms of dehydration are delayed: fatigue and impaired judgment can occur before a user realizes he/she is dehydrated. The hydration sensors indicate dehydration to a user, thus encouraging a user to hydrate and prevent dehydration-related injuries. Data from hydration sensors may be used in determining supply delivery logistics in hostile or inaccessible terrain.

Abstract: A shopping cart storage system allows a user to easily transport elongated items throughout a store. The system includes a shopping cart having a frame, a basket and a plurality of wheels. The basket and the wheels are coupled to the frame. The frame includes a lower bar spaced below the basket. An upper retaining member is coupled to the basket. The upper retaining member has an open top end and an open bottom end. A lower retaining member is coupled to the lower rail. The lower retaining member has a bottom wall and a perimeter wall coupled to and extending upwardly from the bottom wall. The lower retaining member is spaced from and vertically aligned with the upper retaining member wherein the upper and lower retaining members are configured to retain an elongated object in an upright position adjacent to the shopping cart.