Patents by Inventor Jason W. Skudlarek
Jason W. Skudlarek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9624197Abstract: The present invention is directed to 2-pyridylamino-4-nitrile-piperidinyl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridylamino-4-nitrile-piperidinyl compounds described herein in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.Type: GrantFiled: November 22, 2013Date of Patent: April 18, 2017Assignee: MERCK SHARP & DOHME CORP.Inventors: Scott D. Kuduk, Jason W. Skudlarek
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Patent number: 9617246Abstract: The present invention is directed to thioether-piperidinyl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the thioether-piperidinyl compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.Type: GrantFiled: December 16, 2014Date of Patent: April 11, 2017Assignee: MERCK SHARP & DOHME CORP.Inventors: Scott D. Kuduk, Jason W. Skudlarek
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Patent number: 9586950Abstract: The present invention is directed to 2-pyridyloxy-3-ester-4-nitrile compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridyloxy-3-ester-4-nitrile compounds described herein in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.Type: GrantFiled: October 14, 2013Date of Patent: March 7, 2017Assignee: MERCK SHARP & DOHME CORP.Inventors: Scott D. Kuduk, Jason W. Skudlarek
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Patent number: 9586934Abstract: The present invention is directed to 2-pyridyloxy-4-methyl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridyloxy-4-methyl compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.Type: GrantFiled: December 4, 2014Date of Patent: March 7, 2017Assignee: MERCK SHARP & DOHME CORP.Inventors: Scott D. Kuduk, Jason W. Skudlarek
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Patent number: 9556145Abstract: The present invention is directed to 2-pyridyloxy-4-ester compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridyloxy-4-ester compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.Type: GrantFiled: December 16, 2013Date of Patent: January 31, 2017Assignee: MERCK SHARP & DOHME CORP.Inventors: Scott D. Kuduk, Jason W. Skudlarek
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Patent number: 9556190Abstract: The present invention is directed to piperidinyloxy lactone compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the piperidinyloxy lactone compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.Type: GrantFiled: December 18, 2014Date of Patent: January 31, 2017Assignee: MERCK SHARP & DOHME CORP.Inventors: Scott D. Kuduk, Jason W. Skudlarek
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Patent number: 9546152Abstract: The present invention is directed to 2-pyridyloxy-3-substituted-4-nitrile compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridyloxy-3-substituted-4-nitrile compounds described herein in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.Type: GrantFiled: October 21, 2013Date of Patent: January 17, 2017Assignee: MERCK SHARP & DOHME CORP.Inventors: Scott D. Kuduk, Jason W. Skudlarek
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Publication number: 20160368898Abstract: The present invention is directed to 2-pyridyloxy-4-methyl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridyloxy-4-methyl compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.Type: ApplicationFiled: December 4, 2014Publication date: December 22, 2016Applicant: MERCK SHARP & DOHME CORP.Inventors: SCOTT D. KUDUK, JASON W. SKUDLAREK
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Publication number: 20160318944Abstract: The present invention is directed to piperidinyloxy lactone compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the piperidinyloxy lactone compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.Type: ApplicationFiled: December 18, 2014Publication date: November 3, 2016Applicant: MERCK SHARP & DOHME CORP.Inventors: SCOTT D. KUDUK, JASON W. SKUDLAREK
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Publication number: 20160318899Abstract: The present invention is directed to thioether-piperidinyl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the thioether-piperidinyl compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.Type: ApplicationFiled: December 16, 2014Publication date: November 3, 2016Applicant: MERCK SHARP & DOHME CORP.Inventors: SCOTT D. KUDUK, JASON W. SKUDLAREK
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Publication number: 20160318900Abstract: The present invention is directed to 2-amino-3-ester pyridyl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-amino-3-ester pyridyl compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.Type: ApplicationFiled: December 18, 2014Publication date: November 3, 2016Applicant: MERCK SHARP & DOHME CORP.Inventors: SCOTT D. KUDUK, JASON W. SKUDLAREK
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Publication number: 20160304490Abstract: The present invention is directed to 2-pyridyloxy-3-ester-4-ether compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridyloxy-4-ether compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.Type: ApplicationFiled: December 4, 2014Publication date: October 20, 2016Applicant: MERCK SHARP & DOHME CORP.Inventors: SCOTT D. KUDUK, JASON W. SKUDLAREK
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Publication number: 20160214960Abstract: The present invention is directed to 2-pyridyloxy-4-ester compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridyloxy-4-ester compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.Type: ApplicationFiled: December 16, 2013Publication date: July 28, 2016Applicant: MERCK SHARP & DOHME CORP.Inventors: SCOTT D. KUDUK, JASON W. SKUDLAREK
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Patent number: 9314468Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts, solvates, tautomers, stereoisomers, and/or esters thereof. These compounds, and pharmaceutical composition comprising such compounds are useful treating or preventing HIV infections, and in treating proliferative disorders such as inhibiting the metastasis of various cancers.Type: GrantFiled: November 15, 2012Date of Patent: April 19, 2016Assignee: Altiris Therapeutics, Inc.Inventors: Michael P Clark, Florence F Wagner, Michael G Natchus, Brandon C Doroh, Tricia L Johnson, Yesim Altas Tahirovic, Lawrence Wilson, John M Wiseman, Jason W Skudlarek, Mark A Lockwood
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Publication number: 20160102073Abstract: The present invention is directed to 2-hydroxymethyl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.Type: ApplicationFiled: April 21, 2014Publication date: April 14, 2016Applicant: MERCK SHARP & DOHME CORP.Inventors: SCOTT D. KUDUK, JASON W. SKUDLAREK
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Publication number: 20160068510Abstract: The present invention is directed to hydroxy compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.Type: ApplicationFiled: April 21, 2014Publication date: March 10, 2016Applicant: MERCK SHARP & DOHME CORP.Inventors: Scott D. KUDUK, Nigel L. LIVERTON, Jason W. SKUDLAREK
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Publication number: 20160016935Abstract: The present invention is directed to 2-pyridyloxy-4-ether compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridyloxy-4-ether compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.Type: ApplicationFiled: March 3, 2014Publication date: January 21, 2016Applicant: MERCK SHARP & DOHME CORP.Inventors: SCOTT D. KUDUK, JASON W. SKUDLAREK
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Publication number: 20150322039Abstract: The present invention is directed to 2-pyridylamino-4-nitrile-piperidinyl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridylamino-4-nitrile-piperidinyl compounds described herein in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.Type: ApplicationFiled: November 22, 2013Publication date: November 12, 2015Applicant: MERCK SHARP & DOHME CORP.Inventors: SCOTT D. KUDUK, JASON W. SKUDLAREK
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Publication number: 20150322041Abstract: The present invention is directed to 2-pyridyloxy-3-nitrile-4-substituted compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridyloxy-3-nitrile-4-substituted compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.Type: ApplicationFiled: December 16, 2013Publication date: November 12, 2015Applicant: MERCK SHARP & DOHME CORP.Inventors: SCOTT D. KUDUK, JASON W. SKUDLAREK
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Publication number: 20150322040Abstract: The present invention is directed to 3-ester-4-substituted compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 3-ester-4-substituted compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.Type: ApplicationFiled: December 16, 2013Publication date: November 12, 2015Applicant: MERCK SHARP & DOHME CORP.Inventors: Scott D. KUDUK, Jason W. SKUDLAREK