Abstract: Disclosed systems and methods include or support a message logging service in which, responsive to receiving an event message generated by a business function, the message is logged in accordance with a message severity, one or more severity level attributes of the system, and one or more message logging criterion. Responsive to determining the message severity meets a first criterion, the message may be routed to and saved within a first persistent log file. Responsive to determining the message severity satisfies a second criterion, the message may be temporarily stored to a FIFO message queue, for possible inclusion in a second persistent log file. A health monitoring service for monitoring application programs corresponding to various business functions, upon detecting a degraded health state of a business function, may cause messages stored in the message queue to be dumped to a second persistent log file.

Abstract: Disclosed systems and methods may retrieve a base image of a plugin for a hyperconverged infrastructure (HCl) platform and create a Docker image for an HCl platform plugin based, in part, on the base image. The HCl platform plugin enables an extended function not native to the HCl platform. Disclosed methods may include registering the Docker image within an HCl platform instance running on an HCl appliance associated with a customer, and saving the Docker image to a Docker image repository within the HCl platform instance. The extended HCl platform function may be any suitable function including, as an illustrative example, a function for provisioning a third party storage device within the HCl platform. Disclosed method steps may be performed by an independent third party developer that lacks authorized access to an HCl platform instance.

Abstract: Provided herein are engineered hMPV F proteins. In some aspects, the engineered F proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of the engineered F proteins as diagnostics, in screening platforms, and/or in vaccine compositions.

Abstract: A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and (d) using the microfluidic device to identify at least one B cell that produces antibodies capable of binding to cancer cells. The cancer cells can be the patient's own cancer cells. Also provided are methods of treating patients, methods of labeling or detecting cancer, engineered T or NK cells comprising antibodies or fragments thereof, and engineered antibody constructs.

Abstract: A method includes obtaining a multi-utterance training sample that includes audio data characterizing utterances spoken by two or more different speakers and obtaining ground-truth speaker change intervals indicating time intervals in the audio data where speaker changes among the two or more different speakers occur. The method also includes processing the audio data to generate a sequence of predicted speaker change tokens using a sequence transduction model. For each corresponding predicted speaker change token, the method includes labeling the corresponding predicted speaker change token as correct when the predicted speaker change token overlaps with one of the ground-truth speaker change intervals. The method also includes determining a precision metric of the sequence transduction model based on a number of the predicted speaker change tokens labeled as correct and a total number of the predicted speaker change tokens in the sequence of predicted speaker change tokens.

Abstract: The current invention provides a synthetic prokaryotic genome comprising 5 or fewer occurrences of one or more sense codons; and/or a synthetic prokaryotic genome derived from a parent genome, wherein the synthetic prokaryotic genome comprises less than 10%, 5%, 2%, 1%, 0.5%, 0.1% of the occurrences of one or more sense codons, relative to the parent genome; and/or a synthetic prokaryotic genome comprising 100 or more, 200 or more, or 1000 or more genes with no occurrences of one or more sense codons.

Abstract: Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.

Abstract: A vehicle detection system warns snowmobilers of other approaching vehicles with potential risk of collision. To better prevent accidents, the system calculates collision risks and warns the rider based on level of risk. When riding in groups, a member can press a stop request button to ask the group to slow down. When a member exits the group, everyone in the group will receive a message, alerts or indication with the update. The vehicle detection system utilizes Bluetooth® low energy (BLE), LoRaWAN® technologies and/or global positioning system technologies and is designed to detect other devices in the region and use acquired information to calculate proximity and risk of collision.

Abstract: A method of imaging a turbine engine test component with a first surface and a second surface that is spaced from the first surface. The turbine engine test component includes a plurality of film holes with inlets formed in the second surface or interior that are fluidly coupled to outlets formed in the first surface or exterior. The method includes flowing airflow through the plurality of film holes of the turbine engine test component, obtaining thermographic data, determining a test dataset, and calculating a performance score.

Abstract: Systems and methods are provided for vector-quantized image modeling using vision transformers and improved codebook handling. In particular, the present disclosure provides a Vector-quantized Image Modeling (VIM) approach that involves pretraining a machine learning model (e.g., Transformer model) to predict rasterized image tokens autoregressively. The discrete image tokens can be encoded from a learned Vision-Transformer-based VQGAN (example implementations of which can be referred to as ViT-VQGAN). The present disclosure proposes multiple improvements over vanilla VQGAN from architecture to codebook learning, yielding better efficiency and reconstruction fidelity. The improved ViT-VQGAN further improves vector-quantized image modeling tasks, including unconditional image generation, conditioned image generation (e.g., class-conditioned image generation), and unsupervised representation learning.

Abstract: An electronic device may include an antenna and a coaxial cable coupled to the antenna. The coaxial cable may have a signal conductor coupled to an antenna resonating element of the antenna and a ground conductor coupled to an antenna ground of the antenna. The ground conductor may include an ungrounded segment that is separated from the antenna ground by a gap. A capacitive coupling between the ground conductor in the ungrounded segment and the antenna ground via the gap may form an impedance matching component for the coaxial cable. A dielectric retention layer may overlap the coaxial cable and hold the coaxial cable in place relative to the antenna ground to maintain the gap.

Abstract: A system and/or method for imaging system calibration, including: determining a dense correspondence map matching features in a first image to features in a second image, and determining updated calibration parameters associated with the image acquisition system based on the matching features.

Abstract: A cyclo-stationary characteristic of a communications channel and/or storage media is determined. The cyclo-stationary characteristic has K-cycles, K>1. Markov transition probabilities are determined that depend on a discrete phase ?=t mod K, wherein t is a discrete time value. An encoder to optimize the Markov transition probabilities for encoding data sent through the communications channel and/or stored on the storage media. The optimized Markov transition probabilities are used to decode the data from the communication channel and/or read from the storage media.

Abstract: A speaker verification method includes receiving audio data corresponding to an utterance, processing a first portion of the audio data that characterizes a predetermined hotword to generate a text-dependent evaluation vector, and generating one or more text-dependent confidence scores. When one of the text-dependent confidence scores satisfies a threshold, the operations include identifying a speaker of the utterance as a respective enrolled user associated with the text-dependent confidence score that satisfies the threshold and initiating performance of an action without performing speaker verification. When none of the text-dependent confidence scores satisfy the threshold, the operations include processing a second portion of the audio data that characterizes a query to generate a text-independent evaluation vector, generating one or more text-independent confidence scores, and determining whether the identity of the speaker of the utterance includes any of the enrolled users.

Abstract: Various embodiments disclosed herein describe photonic passive delay lines that have a waveguide wound into a plurality of straight segments and bends. The photonic passive delay lines are configured to reduce losses from parasitic modes of light generated at the bends. Embodiments of the photonic passive delay lines vary the dimensions of the straight segments to provide different amounts of dephasing between a mode of input light received by the photonic passive delay line and one or more parasitic modes.

Abstract: Provided herein are opioid receptor modulators and pharmaceutical compositions comprising said compounds.

Abstract: An automatic valve actuator unit and method for use with an associated manual shutoff valve configured to permit or restrict the flow of fluid through an associated supply pipe. The unit comprises a housing, an attachment mechanism for securing the housing to at least one of the associated supply pipe or manual shutoff valve, and an actuator at least partially supported in the housing and having an output shaft extending from the housing. The output shaft includes a locating member supported at a distal end thereof for non-rotatingly engaging a surface of a valve handle of the associated manual shutoff valve adjacent a point of attachment of the handle to the associated manual shutoff valve, the locating member configured to center the output shaft over an axis of rotation of the handle of the associated manual shutoff valve.

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I? and I?? or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.

Abstract: A method for evaluating a verification model includes receiving a first and a second set of verification results where each verification result indicates whether a primary model or an alternative model verifies an identity of a user as a registered user. The method further includes identifying each verification result in the first and second sets that includes a performance metric. The method also includes determining a first score of the primary model based on a number of the verification results identified in the first set that includes the performance metric and determining a second score of the alternative model based on a number of the verification results identified in the second set that includes the performance metric. The method further includes determining whether a verification capability of the alternative model is better than a verification capability of the primary model based on the first score and the second score.