Patents by Inventor Jason Watling
Jason Watling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11787906Abstract: A drug-polymer conjugate, which is a copolymer of at least one monomer of formula (I): (I) where: X may be the same or different at each occurrence and represents a terminal functional group comprising an alkyne or an azide; Q is independently selected at each occurrence and may be present or absent and when present, represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon, optionally substituted aryl and optionally substituted heteroaryl; D is a releasable drug selected from prostaglandins, ?-blockers and mixtures thereof; L is a linker group group; and at least one co-monomer of Formula III III J represents a linking functional group, n is 2 to 8, preferably 3 to 8; Y comprises a polyether of formula (ORa)m wherein Ra is independently ethylene, propylene and butylene and m is from 1 to 300 (preferably 2 to 300) and the polyether is in chain with one or more groups which are preferably selected from one or more of optionally substituted straight or branched C1 toType: GrantFiled: March 14, 2018Date of Patent: October 17, 2023Assignee: POLYACTIVA PTY LTDInventors: Stephen Lonsdale Birkett, Andrew Craig Donohue, Asha Marina D'Souza, Sarah Man Yee Ng, Adrian Sulistio, Russell John Tait, David Valade, Alan Naylor, Jason Watling, Carmen Vittoria Scullino
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Patent number: 11696955Abstract: A polymer-prostaglandin conjugate comprising: a polymer backbone comprising a plurality of moieties of formula (I): where: T represents a triazole moiety; Q is independently selected at each occurrence and may be present or absent and when present represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon; D is selected from prostaglandins; and L is a group of formula (II) wherein R5 is selected from hydrogen and C1 to C6 alkyl; (R) indicates the end of the group bonded to the R group; and (D) indicates the end of the group attached to the group D.Type: GrantFiled: December 23, 2021Date of Patent: July 11, 2023Assignee: POLYACTIVA PTY LTDInventors: Stephen Lonsdale Birkett, Andrew Craig Donohue, Asha Marina D'Souza, Sarah Man Yee Ng, Adrian Sulistio, Russell John Tait, David Valade, Alan Naylor, Jason Watling
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Publication number: 20220401455Abstract: A drug-polymer conjugate, which is a copolymer of at least one monomer of formula (I) where: X may be the same or different at each occurrence and represents a terminal functional group comprising an alkyne or an azide; Q is independently selected at each occurrence and may be present or absent and when present, represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon, optionally substituted aryl and optionally substituted heteroaryl; D is a releasable bicyclic prostaglandin; L is a linker group; and at least one co-monomer of Formula III J-(Y1-A)n, J represents a linking functional group, n is 2 to 8 preferably 3 to 8; Y1 comprises a polyether of formula (ORa)m wherein Ra is independently ethylene, propylene and butylene and m is from 1 to 300 (preferably 2 to 300) and the polyether is in chain with one or more groups which are preferably selected from one or more of optionally substituted straight or branched C1 to C10 alkylene, amino, ether, ester, amide, carbonType: ApplicationFiled: September 19, 2019Publication date: December 22, 2022Applicant: POLYACTIVA PTY LTDInventors: Stephen Lonsdale BIRKETT, Andrew Craig DONOHUE, Asha Marina D'SOUZA, Sarah Man Yee NG, Adrian SULISTIO, Russell John TAIT, David VALADE, Alan NAYLOR, Jason WATLING, Carmen Vittoria SCULLINO
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Publication number: 20220226483Abstract: A polymer-prostaglandin conjugate comprising: a polymer backbone comprising a plurality of moieties of formula (I): where: T represents a triazole moiety; Q is independently selected at each occurrence and may be present or absent and when present represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon; D is selected from prostaglandins; and L is a group of formula (II) wherein R5 is selected from hydrogen and C1 to C6 alkyl; (R) indicates the end of the group bonded to the R group; and (D) indicates the end of the group attached to the group D.Type: ApplicationFiled: December 23, 2021Publication date: July 21, 2022Applicant: POLYACTIVA PTY LTDInventors: Stephen Lonsdale BIRKETT, Andrew Craig DONOHUE, Asha Marina D'SOUZA, Sarah Man Yee NG, Adrian SULISTIO, Russell John TAIT, David VALADE, Alan NAYLOR, Jason WATLING
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Patent number: 11207417Abstract: A polymer-prostaglandin conjugate comprising: a polymer backbone comprising a plurality of moieties of formula (I): where: T represents a triazole moiety; Q is independently selected at each occurrence and may be present or absent and when present represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon; D is selected from prostaglandins; and L is a group of formula (II) wherein R5 is selected from hydrogen and C1 to C6 alkyl; (R) indicates the end of the group bonded to the R group; and (D) indicates the end of the group attached to the group D.Type: GrantFiled: March 14, 2018Date of Patent: December 28, 2021Assignee: POLYACTIVA PTY LTDInventors: Stephen Lonsdale Birkett, Andrew Craig Donohue, Asha Marina D'Souza, Sarah Man Yee Ng, Adrian Sulistio, Russell John Tait, David Valade, Alan Naylor, Jason Watling
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Publication number: 20200121798Abstract: A polymer-prostaglandin conjugate comprising: a polymer backbone comprising a plurality of moieties of formula (I): where: T represents a triazole moiety; Q is independently selected at each occurrence and may be present or absent and when present represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon; D is selected from prostaglandins; and L is a group of formula (II) wherein R5 is selected from hydrogen and C1 to C6 alkyl; (R) indicates the end of the group bonded to the R group; and (D) indicates the end of the group attached to the group D.Type: ApplicationFiled: March 14, 2018Publication date: April 23, 2020Applicant: POLYACTIVA PTY LTDInventors: Stephen Lonsdale BIRKETT, Andrew Craig DONOHUE, Asha Marina D'SOUZA, Sara Man Yee NG, Adrian SULISTIO, Russell John TAIT, David VALADE, Alan NAYLOR, Jason WATLING
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Publication number: 20200123322Abstract: A drug-polymer conjugate, which is a copolymer of at least one monomer of formula (I): (I) where: X may be the same or different at each occurrence and represents a terminal functional group comprising an alkyne or an azide; Q is independently selected at each occurrence and may be present or absent and when present, represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon, optionally substituted aryl and optionally substituted heteroaryl; D is a releasable drug selected from prostaglandins, ?-blockers and mixtures thereof; L is a linker group group; and at least one co-monomer of Formula III III J represents a linking functional group, n is 2 to 8, preferably 3 to 8; Y comprises a polyether of formula (ORa)m wherein Ra is independently ethylene, propylene and butylene and m is from 1 to 300 (preferably 2 to 300) and the polyether is in chain with one or more groups which are preferably selected from one or more of optionally substituted straight or branched Ci toType: ApplicationFiled: March 14, 2018Publication date: April 23, 2020Applicant: POLYACTIVA PTY LTDInventors: Stephen Lonsdale BIRKETT, Andrew Craig DONOHUE, Asha Marina D'SOUZA, Sara Man Yee NG, Adrian SULISTIO, Russell John TAIT, David VALADE, Alan NAYLOR, Jason WATLING, Carmen Vittoria SCULLINO
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Publication number: 20200024403Abstract: The present disclosure relates to injectable compositions and methods of making injectable compositions of moisture curing siloxane polymers for forming accommodating intraocular lenses. In certain embodiments, the moisture curing siloxane polymers are comprised of an organosilicon compound and a hydrolytically sensitive siloxane moiety and have a specific gravity of greater than about 0.95, a number average molecular weight (Mn) greater than about 5,000 or about 20,000 and a weight average molecular weight (Mw) greater than about 20,000 or about 40,000. The disclosure includes accommodating intraocular lenses formed from moisture curing siloxane polymers and having a modulus of elasticity of less than about 6 kPa, less than 20% post-cure extractables, refractive index ranging from 1.4 to 1.5 and dioptric range of accommodation of 0D to 10D.Type: ApplicationFiled: June 4, 2019Publication date: January 23, 2020Inventors: Jason Watling, Stephen Clarke, Kim-Anh Thi Nguyen, Tony Aitchison, Elda Markovic, Anton Blencowe, Chun Kit Lo
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Patent number: 10351675Abstract: The present disclosure relates to injectable compositions and methods of making injectable compositions of moisture curing siloxane polymers for forming accommodating intraocular lenses. In certain embodiments, the moisture curing siloxane polymers are comprised of an organosilicon compound and a hydrolytically sensitive siloxane moiety and have a specific gravity of greater than about 0.95, a number average molecular weight (Mn) greater than about 5,000 or about 20,000 and a weight average molecular weight (Mw) greater than about 20,000 or about 40,000. The disclosure includes accommodating intraocular lenses formed from moisture curing siloxane polymers and having a modulus of elasticity of less than about 6 kPa, less than 20% post-cure extractables, refractive index ranging from 1.4 to 1.5 and dioptric range of accommodation of 0D to 10D.Type: GrantFiled: December 21, 2015Date of Patent: July 16, 2019Assignee: Adventus Technology, Inc.Inventors: Jason Watling, Stephen Clarke, Kim-Anh Thi Nguyen, Tony Aitchison, Elda Markovic, Anton Blencowe, Chun Kit Lo
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Publication number: 20180273687Abstract: The present disclosure relates to injectable compositions and methods of making injectable compositions of moisture curing siloxane polymers for forming accommodating intraocular lenses. In certain embodiments, the moisture curing siloxane polymers are comprised of an organosilicon compound and a hydrolytically sensitive siloxane moiety and have a specific gravity of greater than about 0.95, a number average molecular weight (Mn) greater than about 5,000 or about 20,000 and a weight average molecular weight (Mw) greater than about 20,000 or about 40,000. The disclosure includes accommodating intraocular lenses formed from moisture curing siloxane polymers and having a modulus of elasticity of less than about 6 kPa, less than 20% post-cure extractables, refractive index ranging from 1.4 to 1.5 and dioptric range of accommodation of OD to 10D.Type: ApplicationFiled: December 21, 2015Publication date: September 27, 2018Inventors: Jason Watling, Stephen Clarke, Kim-Anh Thi Nguyen, Tony Aitchison, Elda Markovic, Anton Blencowe, Chun Kit Lo
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Patent number: 7452377Abstract: The invention provides in one form a macromonomer comprising a polysiloxane copolymer having a backbone structure derived from siloxane monomer units that are substituted or unsubstituted arylsiloxanes, arylalkylsiloxanes, alky(alkyl)siloxanes of the general formula —R1R2SiO— and wherein the terminal groups of the copolymer backbone include crosslinkable groups and wherein pendent from the backbone are at least two crosslinkable groups. The macromonomer may be cured in vivo by ultraviolet or visible light. The invention includes intraocular lenses formed by such macromonomers.Type: GrantFiled: July 30, 2003Date of Patent: November 18, 2008Inventors: Jason Watling, Justine Leigh Jeffery, Pathiraja Arachchillage Gunatillake, Timothy Charles Hughes
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Patent number: D505653Type: GrantFiled: September 29, 2003Date of Patent: May 31, 2005Assignee: Land and Marine Products LimitedInventor: Jason Watling