Abstract: Disclosed are compounds of Formula (I): or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.

Abstract: Disclosed are compounds of Formula (I): or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.

Abstract: A method for processing a natural language query. The method includes receiving a text query, the query referring to a plurality of objects, attributes, qualifiers and other arguments and parsing the query to produce an argument tree representing the substance and structure of the query. The method also includes the capability to define qualifiers as being possibly projectable onto other arguments and indicate their direction of projectability and the capability to denote nodes of the argument tree as foldable, as splittable, or as containing sequences of qualifier arguments. The method additionally includes defining validity rules for a domain of knowledge, used to determine whether a list of arguments form a valid granular query component and processing of the argument tree, in view of the above in order to derive a corresponding plurality of granular query components that collectively request the plurality of pieces of information representing the intent of the query.

Abstract: A conversational virtual assistant searches databases using as search result filters current arguments from a user's natural language expression together with conversational arguments stored in an historical conversation state. If a search finds no results, a second search may disregard some or all arguments in order to provide a response that includes some search results. The second search can disregard all conversational arguments or just some, the choice being based on one or more criteria such as: the presence of a conversational phrasing clue; conversational arguments being projectable onto current arguments; the relative importance of argument; the age of arguments; and a specific limit to the number of arguments. Conversational virtual assistants can respond to spoken utterances and to natural language expressions and can ask users for request disambiguation.

Abstract: A digital pulse controller uses digital logic to send pulses to a high side and low side switches of a switch-mode power supply converter. The digital logic uses a pulse frequency mode which includes a frequency targeting mode and an ultrasonic mode. The frequency targeting mode dynamically adjusts the size of the pulses in order to achieve a switching frequency within a desired band. The ultrasonic mode is switched into when the frequency of the pulses are at or below a threshold and the time of the pulses reaches a minimum threshold.

Abstract: A controller produces high-side and low-side control signals. The high and low-side signals are used to switch high-side and low-side transistors in the power stage to control the voltage across the power stage output capacitor of the power stage. A boost feedback charge pump receives the low or high-side signal to increase the charge on a charge pump output capacitor. The controller is configured to send Pulse Frequency Modulation (PFM) high and low-side signals that control the voltage on the power stage output capacitor and charge the charge pump output capacitor. The controller is also configured to send boost feedback (BFB) high and low-side signals that charge the boost feedback capacitor, but are designed to not significantly change the charge on the power stage output capacitor.

Abstract: A Digital-to-Analog Converter (DAC) produces an analog reference value from a first reference input. The analog reference value and an output value are used to produce an analog error signal. An Analog-to-Digital Converter (ADC) converts the analog error signal to a digital value. The ADC has higher level of resolution than the DAC. An error encoder adjusts the digital value to produce a digital error value using a second reference input.

Abstract: A digital pulse controller uses digital logic to send pulses to a high side and low side switches of a switch-mode power supply converter. The digital logic uses a pulse frequency mode which includes a frequency targeting mode and an ultrasonic mode. The frequency targeting mode dynamically adjusts the size of the pulses in order to achieve a switching frequency within a desired band. The ultrasonic mode is switched into when the frequency of the pulses are at or below a threshold and the time of the pulses reaches a minimum threshold.

Abstract: A controller produces high-side and low-side control signals. The high and low-side signals are used to switch high-side and low-side transistors in the power stage to control the voltage across the power stage output capacitor of the power stage. A boost feedback charge pump receives the low or high-side signal to increase the charge on a charge pump output capacitor. The controller is configured to send Pulse Frequency Modulation (PFM) high and low-side signals that control the voltage on the power stage output capacitor and charge the charge pump output capacitor. The controller is also configured to send boost feedback (BFB) high and low-side signals that charge the boost feedback capacitor, but are designed to not significantly change the charge on the power stage output capacitor.