Abstract: A heart valve therapy system including a delivery device and a stented valve. The delivery device includes an outer sheath, an inner shaft, an optional hub assembly, and a plurality of tethers. In a delivery state, a stent frame of the prosthesis is crimped over the inner shaft and maintained in a compressed condition by the outer sheath. The tethers are connected to the stent frame. In a partial deployment state, the outer sheath is at least partially withdrawn, allowing the stent frame to self-expand. Tension in the tethers prevents the stent frame from rapidly expanding and optionally allowing recapture. Upon completion of the stent frame expansion, the tethers are withdrawn.

Abstract: A method of manufacturing a cold box core includes injecting unbonded sand into a cold box core tool, the unbonded sand including sand mixed with a resin, the cold box core tool including: a first platen; a first insert half secured to the first platen; a second platen; and a second insert half secured to the second platen and configured to alternately mate with and separate from the first insert half, each of the first insert half and the second insert half being three-dimensionally printed from a polymer material, the first insert half and the second insert half together forming a cavity therebetween defining an outer geometric shape of the cold box core; and injecting gas into the unbonded sand to harden the cold box core.

Abstract: Exemplary embodiments provided herein include an attachment and deployment system and method. Exemplary embodiments may use features together or separately as desired. The attachment feature may be used to periodically couple a solar sail.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for controlling spraying of chemicals by an unmanned aerial vehicle (UAV). An unmanned aerial vehicle system includes one or more processors configured to perform operations of autonomously performing a flight path by the UAV and dispersing a chemical by the UAV along portions of the flight path. The UAV may include a chemical spray system having one or more spray booms with multiple nozzles for dispersing a chemical. The chemical spray system may include one or more tanks attached to the body of the UAV and a pump fluidly connected to the tanks to disperse chemical via the spray booms.

Abstract: An improved reusable containers system having a first threaded means located on the top of the containers and a second threaded means located on the bottom of the container. The container has an opening on top. The bottom of the container can be either open or closed. The various accessories can be attached to the threaded means. The containers can be secured to one another to create various configurations. Further, there are various accessories which can be secured to the threaded means for special applications.

Abstract: A controller is provided for calibrating an implantable pressure sensor. The controller includes an implantable pressure sensor configured to obtain characteristics of interest related to a patient, one or more processors, and a memory coupled to the one or more processors, wherein the memory stores program instructions. The program instructions are executable by the one or more processors to determine an implantable pressure sensor parameter in real time based on the characteristics of interest related to the patient and provide a drift threshold related to the implantable pressure sensor parameter. The one or more processors are also configured to determine whether the drift threshold has been exceeded based on the implantable pressure sensor parameter and communicate an alert in response to determining the drift threshold has been exceeded.

Abstract: A slide gate assembly is disclosed, comprising a gate frame with an integral frame seal and a slide gate slidably mounted on the gate frame. The gate frame includes a frame opening, a frame support structure, and the integral frame seal with a frame seating face. The slide gate consists of a gate body and an integral gate seal with a gate seating face that seals and slides along the frame seating face. The slide gate is movable between an open orientation, allowing fluid flow through the frame opening, and a closed orientation, restricting fluid flow through the frame opening.

Abstract: The present invention discloses a method for manufacturing a slide gate, involving providing a gate body with a first face and integrally forming an integral gate seal with the gate body through a hybrid manufacturing process. The hybrid manufacturing process includes depositing an additive material onto the first face of the gate body to create the integral gate seal, with the deposition carried out by a first machine. Subsequently, the integral gate seal is machined to achieve the desired size and shape, with the machining also performed by the same first machine. This method combines additive manufacturing and machining techniques to efficiently produce slide gates with integral gate seals of precise dimensions and configurations.

Abstract: A method of producing nanoscale carbon dots suitable for uptake by a plant and with increased affinity to Per- and poly-fluoroalkyl substances wherein the nanoscale carbon dots are synthesized through a hydrothermal reaction of branched polyethyleneimine and citric acid producing polyethyleneimine-based carbon dots.

Abstract: The disclosure relates to gene repressor systems comprising catalytically-dead Class 2 CRISPR proteins and one or more transcription repressor domains linked to the catalytically-dead Class 2 CRISPR protein as a fusion protein, as well as a guide ribonucleic acid (gRNA); and methods of making and using same.

Abstract: A medical device that is at least partially coated with an enhancement layer, and a method for inserting the medical device a patient. One non-limiting type of enhancement layer that can be used includes titanium oxynitride or titanium nitride oxide (TiNOx) and/or zirconium oxynitride (ZrNxOy).

Abstract: Described and demonstrated herein are embodiments of a self-supporting wearable device that can be used for medical training and simulations. Also described herein are methods of using the wearable device described herein.

Abstract: In-line processes for producing scrubby substrates, and related scrubby substrate cleaning articles. The process may include melting a polymer resin material, and extruding or otherwise dispensing the molten polymer resin material through one or more orifices of a heated nozzle, into a stream of hot inert gas, which attenuates the molten resin, so that the resin forms into elongated globules (rather than fibers or filaments). Such globules may have irregular cross-section and/or irregular thickness along a length of the globules. Alternatively, the molten resin may be formed into substantially continuous or discontinuous string or chain pattern of abrasive fibers, exhibiting a high frequency, low amplitude substantially linear pattern on the base substrate. In either case the globules or abrasive fibers are collected onto at least a portion of a base substrate layer to form a scrubby substrate that is more abrasive than typical meltblown materials.

Abstract: Methods and systems for generating physiological metrics for display on a computing device are disclosed herein. In some implementations, an exemplary system comprises a torso wearable device including a wireless transmitter and a sensor, and non-transitory computer-readable media (CRM). The CRM, when executed by a computing device in communication with the wireless transmitter, can perform operations comprising: receiving the input signals representing respiration of the user; displaying a graphical user interface to the user; receiving one or more user inputs associated with a desired metric; displaying on the graphical user interface a first visualization corresponding to the desired metric; and displaying on the graphical user interface a second visualization corresponding to a physiological metric based on the input signals generated from the sensor. The second visualization can change in real time based on real time angular displacement of the sensor in response to the respiration of the user.

Abstract: Disclosed herein is a console comprising: at least one air inlet; a first receptacle configured to host a first source of nitric oxide; a second receptacle configured to host a second source of nitric oxide; a controller configured to selectively couple the at least one air inlet to one of the first receptacle or the second receptacle to deliver the nitric oxide from the first or the second source; and an outlet coupled to the first and/or second receptacle and configured to deliver nitric oxide to a subject.

Abstract: A prosthetic heart valve that is at least partially coated with an enhancement layer, and a method for inserting the prosthetic heart valve in a patient. The prosthetic heart valve includes an expandable frame, a leaflet structure, and optionally an inner skirt and/or an outer skirt. One or more of the components of the prosthetic heart valve can be partially or fully coated with the enhancement layer. One type of enhancement layer that can be used includes titanium oxynitride or titanium nitride oxide (TiNOx) and/or zirconium oxynitride (ZrNxOy).

Abstract: A slide gate includes a gate body defining a first gate face and a second gate face; and an integral gate seal integrally formed with the first gate face, the integral gate seal comprising an additive material additively deposited on the first gate face, the integral gate seal defining a gate seating face.

Abstract: Disclosed herein is a console comprising: at least one air inlet; a first receptacle configured to host a first source of nitric oxide; a second receptacle configured to host a second source of nitric oxide; a controller configured to selectively couple the at least one air inlet to one of the first receptacle or the second receptacle to deliver the nitric oxide from the first or the second source; and an outlet coupled to the first and/or second receptacle and configured to deliver nitric oxide to a subject.

Abstract: A valve body with an integral bypass includes a primary valve body portion defining a primary bore extending through the primary valve body portion from a primary upstream end to a primary downstream end, the primary bore defining an axis, the primary bore including a primary upstream bore extending through the primary upstream end and a primary downstream bore extending through the primary downstream end, the primary valve body portion configured to house a valve member between the primary upstream bore and the primary downstream bore; and the bypass seamlessly integrated with the primary valve body portion, the bypass defining a bypass bore, the bypass bore including a bypass upstream bore and a bypass downstream bore, the bypass including a bypass valve body disposed between the bypass upstream bore and the bypass downstream bore.