Abstract: Disclosed herein is a console comprising: at least one air inlet; a first receptacle configured to host a first source of nitric oxide; a second receptacle configured to host a second source of nitric oxide; a controller configured to selectively couple the at least one air inlet to one of the first receptacle or the second receptacle to deliver the nitric oxide from the first or the second source; and an outlet coupled to the first and/or second receptacle and configured to deliver nitric oxide to a subject.

Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin/kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.

Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.

Abstract: A valve body with an integral bypass includes a primary valve body portion defining a primary bore extending through the primary valve body portion from a primary upstream end to a primary downstream end, the primary bore defining an axis, the primary bore including a primary upstream bore extending through the primary upstream end and a primary downstream bore extending through the primary downstream end, the primary valve body portion configured to house a valve member between the primary upstream bore and the primary downstream bore; and the bypass seamlessly integrated with the primary valve body portion, the bypass defining a bypass bore, the bypass bore including a bypass upstream bore and a bypass downstream bore, the bypass including a bypass valve body disposed between the bypass upstream bore and the bypass downstream bore.

Abstract: Provided herein are devices, systems, and methods for assessing, treating, and for developing new treatments for pulmonary arterial hypertension (PAH) using pulmonary artery pressure (PAP) values and/or cardiac output (CO) estimates.

Abstract: A bar linkage for a pipe coupling can include a first bar configured to span two end rings of the pipe coupling; a second bar configured to span the two end rings of the pipe coupling; and a single tensioner extending through each of the first bar and the second bar and joining the first bar to the second bar along an axis of the bar linkage in an assembled condition of the bar linkage, the tensioner configured to draw the first bar towards the second bar, the first bar and the second bar able to be angled with respect to each other and with respect to the axis of the pipe coupling in a tightened condition of the pipe coupling when viewing the bar linkage from the top when the pipe coupling couples pipes of unequal diameter.

Abstract: Method of cleaning sucker rods using a portable cleaning tool containing a rotating brush assembly to remove scale and corrosion residue on the sucker rods is described herein. The brush is annular with an empty or hollow center, such that the rod can penetrate through the hole in the brush. The tool is powered by air compression, and also contains a mechanism of removing the collected debris for disposal. The cleaning tool assembly could be either a standalone device on site placed on a mounted rack, or could be attached to the rod to be cleaned.

Abstract: Methods and systems for generating physiological metrics for display on a computing device are disclosed herein. In some implementations, an exemplary system comprises a torso wearable device including a wireless transmitter and a sensor, and non-transitory computer-readable media (CRM). The CRM, when executed by a computing device in communication with the wireless transmitter, can perform operations comprising: receiving the input signals representing respiration of the user; displaying a graphical user interface to the user; receiving one or more user inputs associated with a desired metric; displaying on the graphical user interface a first visualization corresponding to the desired metric; and displaying on the graphical user interface a second visualization corresponding to a physiological metric based on the input signals generated from the sensor. The second visualization can change in real time based on real time angular displacement of the sensor in response to the respiration of the user.

Abstract: Start-up protocols for a device and method for administering NO is described.

Abstract: A squeeze doser with a childproof cap is described herein. The squeeze doser with a childproof cap includes a container, a reservoir, and a cap. The container includes a neck. A reservoir is coupled with the neck of the container, wherein the reservoir further comprises a spout and at least one notch located on an outer surface of the neck, said spout coupled with a fill tube that guides liquid stored in the container to the spout, the spout including one or more holes positioned to maintain a predetermined dosage of liquid within the reservoir. The cap is releaseably attached to the neck and includes at least one protrusion that is configured to mate with the at least one notch of the neck, whereby the at least one protrusion coupled with the at least one notch renders the container childproof.

Abstract: Provided herein are devices, systems, and methods for assessing, treating, and for developing new treatments for pulmonary arterial hypertension (PAH) using pulmonary artery pressure (PAP) values and/or cardiac output (CO) estimates.

Abstract: Various systems and methods that may relate to referral and/or delivery services are described. Some embodiments may include billing merchants for delivery services in a consolidated fashion, some embodiments may include interactions with point of sale systems.

Abstract: Systems and methods for tokenization of sensitive data are described, such as a method that includes receiving data to be protected which is provided by a data provider and obtained by or on behalf of a data controller, determining a data controller ID associated with the data controller and a data provider ID associated with the data provider, and generating, by a tokenization engine, a corresponding token for the data controller ID in combination with the data provider ID and in combination with the data to be protected, wherein the token is a reference that maps back to the data to be protected. The data controller ID in combination with the data provider ID and the data to be protected may be stored in a data vault, wherein the data to be protected is accessible from the data vault when the corresponding token is presented.

Abstract: Various systems and methods that may relate to referral and/or delivery services are described. Some embodiments may include billing merchants for delivery services in a consolidated fashion, some embodiments may include interactions with point of sale systems.

Abstract: A seal for a pipe coupling can include an outer gasket defining a radially inner surface defining a plurality of grooves; and an inner gasket separably joined to the outer gasket and defining a radially outer surface, the radially outer surface defining a plurality of ridges extending radially outward and including: a first ridge, each of first and second side surfaces of the first ridge angled in cross-section with respect to a radial direction of the inner gasket towards a first axial end of the inner gasket when in an uncompressed state; and a second ridge, each of first and second side surfaces of the second ridge angled in cross-section with respect to the radial direction towards a second axial end of the inner gasket when in the uncompressed state; wherein the radially outer surfaces of the inner and outer gaskets contact each other.

Abstract: A delivery system for an intracorporeal device includes a sheath defining one or more lumens shaped to receive a delivery catheter or shaft and a guidewire. The system may include a delivery shaft having a distal coupling feature adapted to releasably couple with a proximal coupling feature of the intracorporeal device. The delivery system may further include a hub through which the delivery shaft and guidewire are passed. The delivery shaft may be coupled to a feature, such as a knob, that enables manipulation of the delivery shaft to decouple the distal fixation feature from the proximal fixation feature of the intracorporeal device in order to deploy the intracorporeal device within a patient.

Abstract: The present invention teaches multilayer cleaning articles that include a substantially dry surface contact layer and a gripping layer. The contact layer may represent one exposed major face of the cleaning article (e.g., a cleaning pad), while the gripping layer may represent the opposite exposed major face of the cleaning article. The contact layer may include abrasive synthetic fibers, so as to be effective in scrubbing soils and spills from a surface. The contact layer includes a cleaning composition pre-loaded therein. The cleaning composition is such that the contact layer feels dry to the touch prior to use, before wetting with water. The cleaning composition may include about 1% to about 40% by weight water. The gripping layer includes at least 40% by weight of pulp fibers (e.g., natural cellulose pulp fiber), and exhibits a mean hand grip value that is at least 0.015 1/in2 (reciprocal inches squared).

Abstract: A slide gate includes a gate body defining a first gate face and a second gate face; and an integral gate seal integrally formed with the first gate face, the integral gate seal comprising an additive material additively deposited on the first gate face, the integral gate seal defining a gate seating face.