Patents by Inventor Jason Whitt
Jason Whitt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140296708Abstract: A transvascular system (10) for delivering a drug to a tissue region from a blood vessel, such as a coronary vein, includes a catheter (12) having a distal portion (26) with puncturing (14), orientation (16), drug delivery (62), and imaging elements (18). The puncturing element (14) is deployable for penetrating the vessel wall to access the tissue region. The orientation element (16), e.g. a “cage” including a plurality of struts (38) (40) and/or a radiopaque marker, has a predetermined relationship with the puncturing element (14), the imaging element (18) detecting the location of the orientation element (16) with respect to the tissue region to orient the puncturing element. The catheter (12) is percutaneously introducing into the vessel, the puncturing element (14) is oriented towards the tissue region, the puncturing element (14) is deployed to access the tissue region, and the drug is delivered to the tissue region.Type: ApplicationFiled: April 23, 2014Publication date: October 2, 2014Applicant: Medtronic Vascular, Inc.Inventors: Christopher Flaherty, Joshua Makower, Philip Evard, Patrick Macaulay, Jason Whitt, Robert Colloton
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Publication number: 20140249507Abstract: A transvascular system (10) for delivering a drug to a tissue region from a blood vessel, such as a coronary vein, includes a catheter (12) having a distal portion (26) with puncturing (14), orientation (16), drug delivery (62), and imaging elements (18). The puncturing element (14) is deployable for penetrating the vessel wall to access the tissue region. The orientation element (16), e.g. a “cage” including a plurality of struts (38) (40) and/or a radiopaque marker, has a predetermined relationship with the puncturing element (14), the imaging element (18) detecting the location of the orientation element (16) with respect to the tissue region to orient the puncturing element. The catheter (12) is percutaneously introducing into the vessel, the puncturing element (14) is oriented towards the tissue region, the puncturing element (14) is deployed to access the tissue region, and the drug is delivered to the tissue region.Type: ApplicationFiled: September 20, 2013Publication date: September 4, 2014Applicant: Medtronic Vascular, Inc.Inventors: Christopher Flaherty, Joshua Makower, Philip Evard, Patrick Macaulay, Jason Whitt, Robert Colloton
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Patent number: 8083708Abstract: A transvascular system for delivering a drug to a tissue region from a blood vessel includes a catheter having a distal portion with puncturing, orientation, drug delivery, and imaging elements. The puncturing element is deployable for penetrating the vessel wall to access the tissue region. The orientation element has a predetermined relationship with the puncturing element, the imaging element detecting the location of the orientation element with respect to the tissue region to orient the puncturing element. The catheter is percutaneously introduced into the vessel, the puncturing element is oriented towards the tissue region, the puncturing element is deployed to access the tissue region, and the drug is delivered to the tissue region. An ablation device may also be deployed to create a cavity or fluid reservoir in the tissue region for receiving the drug therein, or an indwelling catheter may be advanced into and left in the tissue region.Type: GrantFiled: March 1, 2010Date of Patent: December 27, 2011Assignee: Medtronic Vascular, Inc.Inventors: Christopher Flaherty, Joshua Makower, Philip Evard, Patrick MacAulay, Jason Whitt, Robert Colloton, K. Angela MacFarlane
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Publication number: 20110178106Abstract: 5-Quinolinone and Imidazopyrimidine compounds are provided that are useful for inhibiting the efflux of any therapeutic agent that is a MRP1 substrate. Also provided is a method for screening to identify additional MRP1 inhibitors.Type: ApplicationFiled: July 10, 2009Publication date: July 21, 2011Applicant: SOUTHERN RESEARCH INSTITUTE OFFICE OF COMMERCIALIZInventors: Joseph A. Maddry, Adam Keeton, Jason Whitt, Gary Piazza
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Patent number: 7955343Abstract: Methods and apparatus for occluding blood flow within a blood vessel. In a first series of embodiments, the present invention comprises a plurality of embolic devices deployable through the lumen of a conventional catheter such that when deployed, said embolic devices remain resident and occlude blood flow at a specific site within the lumen of the blood vessel. Such embolic devices comprise either mechanical embolic devices that become embedded within or compress against the lumen of the vessel or chemical vaso-occlusive agents that seal off blood flow at a given site. A second embodiment of the present invention comprises utilization of a vacuum/cauterizing device capable of sucking in the lumen of the vessel about the device to maintain the vessel in a closed condition where there is then applied a sufficient amount of energy to cause the tissue collapsed about the device to denature into a closure.Type: GrantFiled: October 26, 2007Date of Patent: June 7, 2011Assignee: Medtronic Vascular, Inc.Inventors: Joshua Makower, J. Christopher Flaherty, Timothy Machold, Jason Whitt, Philip Evard, Patrick Macaulay, John Garibotto, Marc Jensen
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Patent number: 7670329Abstract: A transvascular system (10) for delivering a drug to a tissue region from a blood vessel, such as a coronary vein, includes a catheter (12) having a distal portion (26) with puncturing (14), orientation (16), drug delivery (62), and imaging elements (18). The puncturing element (14) is deployable for penetrating the vessel wall to access the tissue region. The orientation element (16), e.g. a “cage” including a plurality of struts (38) (40) and/or a radiopaque marker, has a predetermined relationship with the puncturing element (14), the imaging element (18) detecting the location of the orientation element (16) with respect to the tissue region to orient the puncturing element. The catheter (12) is percutaneously introducing into the vessel, the puncturing element (14) is oriented towards the tissue region, the puncturing element (14) is deployed to access the tissue region, and the drug is delivered to the tissue region.Type: GrantFiled: August 15, 2006Date of Patent: March 2, 2010Assignee: Medtronic Vascular, Inc.Inventors: Christopher Flaherty, Joshua Makower, Philip Evard, Patrick Macaulay, Jason Whitt, Robert Colloton, K. Angela MacFarlane
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Publication number: 20080045996Abstract: Methods and apparatus for occluding blood flow within a blood vessel. In a first series of embodiments, the present invention comprises a plurality of embolic devices deployable through the lumen of a conventional catheter such that when deployed, said embolic devices remain resident and occlude blood flow at a specific site within the lumen of the blood vessel. Such embolic devices comprise either mechanical embolic devices that become embedded within or compress against the lumen of the vessel or chemical vaso-occlusive agents that seal off blood flow at a given site. A second embodiment of the present invention comprises utilization of a vacuum/cauterizing device capable of sucking in the lumen of the vessel about the device to maintain the vessel in a closed condition where there is then applied a sufficient amount of energy to cause the tissue collapsed about the device to denature into a closure.Type: ApplicationFiled: October 26, 2007Publication date: February 21, 2008Applicant: Medtronic Vascular, Inc.Inventors: Joshua Makower, J. Christopher Flaherty, Timothy Machold, Jason Whitt, Philip Evard, Patrick Macaulay, John Garibotto, Marc Jensen
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Patent number: 7316655Abstract: Devices and methods for achieving directed placement of guidewires or other flexible rails over which other catheters or other devices may be introduced to a targeted location. A guidewire directing device includes a lumen extending between a proximal end and a distal peripheral opening for directing a guidewire laterally from the device, and may have a deflecting member with a predetermined deflection angle in the lumen adjacent the peripheral opening. A snaring device is also provided that includes one or more lumens through which a snare or other grasping member is directed for releasably capturing or coupling to a guidewire. The snaring and target guidewire devices may include cooperating end effectors for releasably coupling or securing the devices together.Type: GrantFiled: April 30, 2002Date of Patent: January 8, 2008Assignee: Medtronic Vascular, Inc.Inventors: John Garibotto, Steven W. Kim, Jason Whitt, J. Christopher Flaherty, Joshua Makower, Motoya Hayase, John Chang
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Publication number: 20070021730Abstract: A transvascular system (10) for delivering a drug to a tissue region from a blood vessel, such as a coronary vein, includes a catheter (12) having a distal portion (26) with puncturing (14), orientation (16), drug delivery (62), and imaging elements (18). The puncturing element (14) is deployable for penetrating the vessel wall to access the tissue region. The orientation element (16), e.g. a “cage” including a plurality of struts (38) (40) and/or a radiopaque marker, has a predetermined relationship with the puncturing element (14), the imaging element (18) detecting the location of the orientation element (16) with respect to the tissue region to orient the puncturing element. The catheter (12) is percutaneously introducing into the vessel, the puncturing element (14) is oriented towards the tissue region, the puncturing element (14) is deployed to access the tissue region, and the drug is delivered to the tissue region.Type: ApplicationFiled: August 15, 2006Publication date: January 25, 2007Applicant: Medtronic Vascular, Inc.Inventors: Christopher Flaherty, Joshua Makower, Philip Evard, Patrick Macaulay, Jason Whitt, Robert Colloton, K. MacFarlane
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Publication number: 20060184089Abstract: Methods and apparatus for direct coronary revascularization wherein a transmyocardial passageway is formed between a chamber of the heart and a coronary blood vessel to permit blood to flow therebetween. In some embodiments, the transmyocardial passageway is formed between a chamber of the heart and a coronary vein. The invention includes unstented transmyocardial passageways, as well as transmyocardial passageways wherein protrusive stent devices extend from the transmyocardial passageway into an adjacent coronary vessel or chamber of the heart. The apparatus of the present invention include protrusive stent devices for stenting of transmyocardial passageways, intraluminal valving devices for valving of transmyocardial passageways, intracardiac valving devices for valving of transmyocardial passageways, endogenous tissue valves for valving of transmyocardial passageways, and ancillary apparatus for use in conjunction therewith.Type: ApplicationFiled: January 30, 2006Publication date: August 17, 2006Inventors: Joshua Makower, J. Flaherty, Timothy Machold, Jason Whitt, Margaret Tumas, Theodore Lamson, Marc Jensen
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Publication number: 20020123698Abstract: Devices and methods for achieving directed placement of guidewires or other flexible rails over which other catheters or other devices may be introduced to a targeted location. A guidewire directing device includes a lumen extending between a proximal end and a distal peripheral opening for directing a guidewire laterally from the device, and may have a deflecting member with a predetermined deflection angle in the lumen adjacent the peripheral opening. A snaring device is also provided that includes one or more lumens through which a snare or other grasping member is directed for releasably capturing or coupling to a guidewire. The snaring and target guidewire devices may include cooperating end effectors for releasably coupling or securing the devices together.Type: ApplicationFiled: April 30, 2002Publication date: September 5, 2002Applicant: Transvascular, Inc.Inventors: John Garibotto, Steven W. Kim, Jason Whitt, J. Christopher Flaherty, Joshua Makower, Motoya Hayase, John Chang
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Patent number: 6379319Abstract: Devices and methods for achieving directed placement of guidewires or other flexible rails over which other catheters or other devices may be introduced to a targeted location. A guidewire directing device includes a lumen extending between a proximal end and a distal peripheral opening for directing a guidewire laterally from the device, and may have a deflecting member with a predetermined deflection angle in the lumen adjacent the peripheral opening. A snaring device is also provided that includes one or more lumens through which a snare or other grasping member is directed for releasably capturing or coupling to a guidewire. The snaring and target guidewire devices may include cooperating end effectors for releasably coupling or securing the devices together.Type: GrantFiled: October 27, 1998Date of Patent: April 30, 2002Assignee: Transvascular, Inc.Inventors: John Garibotto, Steven W. Kim, Jason Whitt, J. Christopher Flaherty, Joshua Makower, Motoya Hayase, John Chang