Patents by Inventor Jason William Castle
Jason William Castle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220041976Abstract: A system for isolating a target molecule from a bioprocess fluid includes a single-use disposable separation device having a plurality of perimeter-bonded layers defining one or more mesofluidic channels of the separation device, wherein each layer includes a biocompatible polymer material, wherein the separation device is configured to separate at least a portion of particles from the bioprocess fluid to generate a substantially clarified bioprocess fluid, and a chromatography system fluidically coupled at the outflow of the separation device in a configuration for further processing the clarified bioprocess fluid.Type: ApplicationFiled: August 30, 2019Publication date: February 10, 2022Inventors: Matthew Jeremiah Misner, Rachel Marie Gettings, Christine Angela Morton, Erik Leeming Kvam, Jason William CASTLE, Anindya Kanti De, Jared Timothy Hale, Craig Patrick Galligan, Vincent Francis Pizzi
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Patent number: 11028359Abstract: A system for isolating a target molecule from a bioprocess fluid includes a single-use disposable separation device having a plurality of perimeter-bonded layers defining one or more mesofluidic channels of the separation device, wherein each layer includes a biocompatible polymer material, wherein the separation device is configured to separate at least a portion of particles from the bioprocess fluid to generate a substantially clarified bioprocess fluid, and a chromatography system fluidically coupled at the outflow of the separation device in a configuration for further processing the clarified bioprocess fluid.Type: GrantFiled: September 11, 2018Date of Patent: June 8, 2021Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Matthew Jeremiah Misner, Rachel Marie Gettings, Christine Angela Morton, Erik Leeming Kvam, Jason William Castle, Anindya Kanti De, Jared Timothy Hale, Craig Patrick Galligan, Vincent Francis Pizzi
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Patent number: 11007285Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.Type: GrantFiled: July 22, 2020Date of Patent: May 18, 2021Assignee: GENERAL ELECTRIC COMPANYInventors: Matthew David Butts, Jason William Castle, Andrew Soliz Torres, Jeannette Christine Roberts, Binil Itty Ipe Kandapallil
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Publication number: 20200345869Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.Type: ApplicationFiled: July 22, 2020Publication date: November 5, 2020Inventors: Matthew David BUTTS, Jason William CASTLE, Andrew Soliz TORRES, Jeannette Christine ROBERTS, Binil Itty Ipe KANDAPALLIL
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Patent number: 10751429Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.Type: GrantFiled: August 13, 2018Date of Patent: August 25, 2020Assignee: GENERAL ELECTRIC COMPANYInventors: Matthew David Butts, Jason William Castle, Andrew Soliz Torres, Jeannette Christine Roberts, Binil Itty Ipe Kandapallil
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Publication number: 20200080047Abstract: A system for isolating a target molecule from a bioprocess fluid includes a single-use disposable separation device having a plurality of perimeter-bonded layers defining one or more mesofluidic channels of the separation device, wherein each layer includes a biocompatible polymer material, wherein the separation device is configured to separate at least a portion of particles from the bioprocess fluid to generate a substantially clarified bioprocess fluid, and a chromatography system fluidically coupled at the outflow of the separation device in a configuration for further processing the clarified bioprocess fluid.Type: ApplicationFiled: September 11, 2018Publication date: March 12, 2020Inventors: Matthew Jeremiah Misner, Rachel Marie Gettings, Christine Angela Morton, Erik Leeming Kvam, Jason William Castle, Anindya Kanti De, Jared Timothy Hale, Craig Patrick Galligan, Vincent Francis Pizzi
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Patent number: 10518196Abstract: A separation device, system and associated method are provided herein for separation of particulates form a base fluid. The separation device comprises a first microchannel comprising a fluid inlet and a mesofluidic collection chamber. The mesofluidic collection chamber has a first side and a second side, wherein the mesofluidic collection chamber is operatively coupled to the first microchannel on the first side, and wherein the mesofluidic collection chamber comprises a first fluid outlet at the second side, such that the fluid inlet, first microchannel, and first fluid outlet are in fluidic communication via the mesofluidic collection chamber.Type: GrantFiled: July 13, 2016Date of Patent: December 31, 2019Assignee: General Electric CompanyInventors: Christopher Michael Puleo, Craig Patrick Galligan, Gregory Andrew Grossman, Erik Leeming Kvam, Robert Scott Duthie, Kenneth Wayne Rigby, Paul Michael Smigelski, Jr., Victoria Eugenia Cotero, Jason William Castle, John Donald Burczak, James Edward Rothman
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Publication number: 20180344880Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.Type: ApplicationFiled: August 13, 2018Publication date: December 6, 2018Inventors: Matthew David BUTTS, Jason William CASTLE, Andrew Soliz TORRES, Jeannette Christine ROBERTS, Binil Itty Ipe KANDAPALLIL
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Patent number: 10052394Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.Type: GrantFiled: November 21, 2014Date of Patent: August 21, 2018Assignee: GENERAL ELECTRIC COMPANYInventors: Matthew David Butts, Jason William Castle, Andrew Soliz Torres, Jeannette Christine Roberts, Binil Itty Ipe Kandapallil
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Publication number: 20180001231Abstract: A separation device, system and associated method are provided herein for separation of particulates form a base fluid. The separation device comprises a first microchannel comprising a fluid inlet and a mesofluidic collection chamber. The mesofluidic collection chamber has a first side and a second side, wherein the mesofluidic collection chamber is operatively coupled to the first microchannel on the first side, and wherein the mesofluidic collection chamber comprises a first fluid outlet at the second side, such that the fluid inlet, first microchannel, and first fluid outlet are in fluidic communication via the mesofluidic collection chamber.Type: ApplicationFiled: July 13, 2016Publication date: January 4, 2018Inventors: Christopher Michael Puleo, Craig Patrick Galligan, Gregory Andrew Grossmann, Erik Leeming Kvam, Robert Scott Duthie, Kenneth Wayne Rigby, Paul Michael Smigelski, JR., Victoria Eugenia Cotero, Jason William Castle, John Donald Burczak, James Edward Rothman
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Publication number: 20160144059Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.Type: ApplicationFiled: November 21, 2014Publication date: May 26, 2016Inventors: Matthew David Butts, Jason William Castle, Andrew Soliz Torres, Jeannette Christine Roberts, Binil Itty Ipe Kandapallil
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Patent number: 8937047Abstract: Provided herein are methods of reducing liver uptake in vivo of a polypeptide that specifically binds to a target comprising: (a) providing a polypeptide that specifically binds to a target; and (b) substituting at least one basic or at least one neutral amino acid residue of the native polypeptide from step (a) with an acidic amino acid residue to produce a modified polypeptide, wherein the modified polypeptide demonstrates an isoelectric point at least 0.05-0.1 pH points less than the isoelectric point of the native polypeptide. Also provided are polypeptides made using the inventive methods as well as imaging techniques that employ the methods and agents.Type: GrantFiled: December 19, 2007Date of Patent: January 20, 2015Assignee: General Electric CompanyInventors: Michael Ernest Marino, Faisal Ahmed Syud, Jason William Castle, Brian Duh-Lan Lee, Malin Lindborg, Elin Gunneriusson, Christofer Lendel
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Patent number: 8905992Abstract: A portable microbubble and drug mixing device is provided. The portable microbubble and drug mixing device comprises a flexible outer container comprising an interior chamber for accommodating a drug, and a rigid inner container within the flexible outer container and comprising an interior chamber for accommodating microbubbles. The outer container has a tensile strength at break less than or equal to approximately 15 MPa, and the inner container has a tensile strength at break greater than or equal to approximately 20 MPa and is capable of storing microbubbles at a concentration higher than or equal to approximately 5×106 microbubbles/ml. The inner container is configured to separate the microbubbles in the interior chamber of the inner container from the drug in the interior chamber of the outer container until a point of mixing when the microbubbles are released into the interior chamber of the outer container.Type: GrantFiled: November 7, 2011Date of Patent: December 9, 2014Assignee: General Electric CompanyInventors: Kevin Peter Kent, Hae Won Lim, Jason William Castle
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Publication number: 20130112575Abstract: A portable microbubble and drug mixing device is provided. The portable microbubble and drug mixing device comprises a flexible outer container comprising an interior chamber for accommodating a drug, and a rigid inner container within the flexible outer container and comprising an interior chamber for accommodating microbubbles. The outer container has a tensile strength at break less than or equal to approximately 15 MPa, and the inner container has a tensile strength at break greater than or equal to approximately 20 MPa and is capable of storing microbubbles at a concentration higher than or equal to approximately 5×106 microbubbles/ml. The inner container is configured to separate the microbubbles in the interior chamber of the inner container from the drug in the interior chamber of the outer container until a point of mixing when the microbubbles are released into the interior chamber of the outer container.Type: ApplicationFiled: November 7, 2011Publication date: May 9, 2013Applicant: GENERAL ELECTRIC COMPANYInventors: Kevin Peter Kent, Hae Won Lim, Jason William Castle
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Publication number: 20120114563Abstract: The present invention relates to a method of in vivo optical imaging, of the margins around tumours, which comprises an optical imaging contrast agent. The optical imaging agents comprise conjugates of near-infrared dyes with synthetic polyethylene glycol (PEG) polymers having a molecular weight in the range 15-45 kDa. Also disclosed are optical imaging contrast agents, pharmaceutical compositions and kits.Type: ApplicationFiled: March 19, 2010Publication date: May 10, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: Randall Lee Carter, Jason William Castle, Kenneth Michael Fish, Anup Sood, Natalie Anne Staples, Brian Duh-Lan Lee
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Patent number: 7846735Abstract: Provided herein are compositions and methods for lipoprotein uptake assay. These compositions and methods may be used for lipoprotein uptake assays, including high-throughput assays. The disclosed compositions and method may further be used to characterize the activity agents that inhibit or stimulate lipoprotein uptake.Type: GrantFiled: August 22, 2007Date of Patent: December 7, 2010Assignee: General Electric CompanyInventors: Anton Beletskii, Liming Lu, Jason William Castle
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Publication number: 20100143258Abstract: In one aspect, the present invention provides a functionalized monodisperse polylysine comprising a linear monodisperse polylysine chain comprising constituent lysine monomer residues containing appended C4-C24 polyethylene glycol groups and at least one appended fluorescent dye moiety is provided.Type: ApplicationFiled: December 5, 2008Publication date: June 10, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Anup Sood, Jason William Castle, Evelina Roxana Loghin, Natalie Anne Staples, Kenneth Michael Fish, Randall Lee Carter, Brian Duh-Lan Lee, Kathleen Bove
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Publication number: 20090274623Abstract: Provided are in vivo imaging agents comprising muteins of hTLc having detectable binding affinity for c-Met or a domain thereof, coupled to a signal generator, and the mutein coupled to a signal generator is disposed in a pharmaceutically acceptable carrier. Also provided are diagnostic methods using in vivo imaging agents comprising muteins of hTLc having detectable binding affinity for c-Met or a domain thereof.Type: ApplicationFiled: January 30, 2008Publication date: November 5, 2009Applicant: GENERAL ELECTRIC COMPANYInventors: Clifford L. Smith, Faisal Ahmed Syud, Brian Duh-Lan Lee, Matthew Sam Morrison, Michael Ernest Marino, Jason William Castle, Paul Schaffer, Gabriele Matschiner, Andreas Hohlbaum, Martin Huelsmeyer, Stefan Trentmann
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Publication number: 20090180954Abstract: Provided herein are methods of reducing liver uptake in vivo of a polypeptide that specifically binds to a target comprising: (a) providing a polypeptide that specifically binds to a target; and (b) substituting at least one basic or at least one neutral amino acid residue of the native polypeptide from step (a) with an acidic amino acid residue to produce a modified polypeptide, wherein the modified polypeptide demonstrates an isoelectric point at least 0.05-0.1 pH points less than the isoelectric point of the native polypeptide. Also provided are polypeptides made using the inventive methods as well as imaging techniques that employ the methods and agents.Type: ApplicationFiled: December 19, 2007Publication date: July 16, 2009Applicant: GENERAL ELECTRIC COMPANYInventors: Michael Ernest Marino, Faisal Ahmed Syud, Jason William Castle, Brian Duh-Lan Lee
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Patent number: 7279296Abstract: Provided herein are compositions and methods for lipoprotein uptake assay. These compositions and methods may be used for the lipoprotein uptake assays, including high-throughput assays. The disclosed compositions and method may further be used to characterize the activity agents that inhibit or stimulate lipoprotein uptake.Type: GrantFiled: December 16, 2005Date of Patent: October 9, 2007Assignee: General Electric CompanyInventors: Anton Beletskii, Liming Yu, Jason William Castle