Abstract: The high-voltage and/or high-frequency pulse dielectric breakdown strength (DBS) of an implantable medical device is increased by strategically positioning insulation materials on or adjacent to the external surfaces of a filter capacitor. Dielectric breakdown strength is further increased by adding polymeric or ceramic nanoscale metal oxide insulative powders to the insulation materials.

Abstract: A self-centering washer is positioned between the feedthrough and filter capacitor of a filtered feedthrough. The washer has openings through which first and second terminal pins extend. A first opening has an inner arcuate portion contacting the first terminal pin and an outer perimeter portion exposing the braze sealing the terminal pin to the insulator. A second opening has an inner arcuate portion contacting the second terminal pin and an outer perimeter portion exposing the braze sealing the terminal pin to the insulator. In an imaginary configuration with the first and second washer openings superimposed one on top of the other, the cumulative arcuate distance of the inner arcuate portions about one of the terminal pins, subtracting overlap, results in a gap between the superimposed washer openings that is less than a diameter of the first and second terminal pins so that the washer is prevented from lateral movement.

Abstract: Methods, systems, and computer storage media for providing an optimal control configuration for a material processing system are provided. In operation, a material processing engine accesses causal graph input data. Causal graph input data includes input data of a continuous flow process. Based on the causal graph and the input data, a causal graph that aligns with do-calculus manipulations—associated with determining identifiable causal relationships corresponding to input materials of the continuous flow process—is generated. The causal graph is parsed based on the do-calculus manipulations to determine valid conditioning sets associated with estimating a causal impact on an optimization target. Based on the valid conditioning sets, an optimal control configuration comprising optimal control variable values is generated.

Abstract: Disclosed herein are compositions and methods for the treatment of bronchiolitis obliterans syndrome (BOS), in particular, in association with hematopoietic stem cell transplant (HSCT recipients, and methods for patients for effective treatment of same using protein and functional biomarkers. In certain aspect, the disclosed compositions and methods may be used for early identification of individuals likely to develop BOS such that optimal treatment may be provided, wherein the methods may employ detection and assessment of one or both of a biomarker and lung function.

Abstract: Techniques and structures to prevent exhaustion of a database connection pool, including retrieving data from the database connection pool, monitoring the data to determine whether the connection pool is at risk of an exhaustion condition, analyzing the data to determine whether one or more clients accessing the database connection pool are offenders upon determining that the connection pool is at risk and throttling access to the one or more clients accessing the database connection pool upon determining the one or more clients to be offenders.

Abstract: Techniques and structures to facilitate automatic adjustment of a database connection pool, including calculating a first value indicating a number of connections of to be provided by a first of a plurality of application servers, determining whether the first value is equal to a second value previously calculated to indicate the number of connections to be provided by the first application server and adjusting the database connection pool by providing the number of connections to access the database as indicated by the first value upon a determination that the first value is not equal to the second value.

Abstract: A feedthrough for an AIMD is described. The feedthrough includes an electrically conductive ferrule having a ferrule sidewall defining a ferrule opening. The ferrule sidewall has a height. At least one recessed pocket has a depth extending part-way through the height of the ferrule. An oxide-resistant pocket-pad is nested in the recessed pocket. An electrical connection material is supported on the pocket-pad for making an oxide-resistant electrical connection to the ferrule. An insulator is hermetically sealed to the ferrule in the ferrule opening. At least one active via hole extends through the insulator with an active conductive pathway residing in and hermetically sealed to the insulator in the active via hole.

Abstract: An interventional medical device includes an insertion tube extending between a proximal end and a distal end. The distal end configured to be inserted into internal tissues of a patient during a medical procedure. The insertion tube has an internal channel. The interventional medical device includes a tool received in the internal channel of the insertion tube. The tool has a tool body and a needle at an end of the tool body forms a tip of the tool. The tool body forms a tool channel. The interventional medical device includes a pressure sensor module received in the tool channel. The pressure sensor module includes a pressure sensor and a carrier holding the pressure sensor. The carrier is coupled to the tool body to position the pressure sensor in the tool channel proximate to the tip of the tool for measuring pressure of fluid of the internal tissues of the patient.

Abstract: A hermetically sealed feedthrough assembly for an active implantable medical device having an oxide-resistant electrical attachment for connection to an EMI filter, an EMI filter circuit board, an AIMD circuit board, or AIMD electronics. The oxide-resistant electrical attachment, including an oxide-resistant sputter layer 165 is disposed on the device side surface of the hermetic seal ferrule over which an ECA stripe is provided. The ECA stripe may comprise one of a thermal-setting electrically conductive adhesive, an electrically conductive polymer, an electrically conductive epoxy, an electrically conductive silicone, an electrically conductive polyimides, or an electrically conductive polyimide, such as those manufactured by Ablestick Corporation. The oxide-free electrical attachment between the ECA stripe and the filter or AIMD circuits may comprise one of gold, platinum, palladium, silver, iridium, rhenium, rhodium, tantalum, tungsten, niobium, zirconium, vanadium, and combinations or alloys thereof.

Abstract: Disclosed are some implementations of systems, apparatus, methods and computer program products for implementing a shim driver configurable to provide a database driver. A shim driver class is loaded from a class path and instantiated such that a shim driver is generated. A directory path and database driver class name are obtained from a configuration file. An application transmits a request for a database driver via an application programming interface (API) of the shim driver, where the request includes the directory path and database driver class name. The shim driver loads a database driver class identified by the database driver class name using the directory path, instantiates the database driver class such that a first database driver is generated, and provides the first database driver responsive to the request.

Abstract: A tube-in-tube heat exchanger utilizes a selectively permeable tube having a selective permeable layer to allow the refrigerant to transfer into an ionic liquid to generate heating or cooling. The ionic liquid then provides heating or cooling to a heat transfer fluid through a non-permeable layer or tube. The system may be configured as a shell and tube design, with the third fluid free to flow on the outside of the shell, or as a shell and tube-in-tube, with a central tube containing a first liquid, a second tube containing a second liquid, and an outer shell containing the third liquid. The selectively permeable tube may include an anion or cation selectively permeable layer and this layer may be supported by a support layer or tube.

Abstract: A hermetically sealed feedthrough assembly for an active implantable medical device having an oxide-resistant electrical attachment for connection to an EMI filter, an EMI filter circuit board, an AIMD circuit board, or AIMD electronics. The oxide-resistant electrical attachment, including an oxide-resistant sputter layer 165 is disposed on the device side surface of the hermetic seal ferrule over which an ECA stripe is provided. The ECA stripe may comprise one of a thermal-setting electrically conductive adhesive, an electrically conductive polymer, an electrically conductive epoxy, an electrically conductive silicone, an electrically conductive polyimide, or a thermal-setting electrically conductive polyimide, such as those manufactured by Ablestick Corporation.

Abstract: Within one or more instances of a computing environment where an instance is a self-contained architecture to provide at least one database with corresponding search and file system. User information from the one or more instances of the computing environment is organized as zones. A zone is based on one or more characteristics of corresponding user information that are different than the instance to which the user information belongs. User information is selectively obfuscated prior to transmitting blocks of data including the obfuscated user information. The selective obfuscation is based on zone information for one or more zones to which the user information belongs.

Abstract: A tube-in-tube heat exchanger utilizes a selectively permeable tube having a selective permeable layer to allow the refrigerant to transfer into an ionic liquid to generate heating or cooling. The ionic liquid then provides heating or cooling to a heat transfer fluid through a non-permeable layer or tube. The system may be configured as a shell and tube design, with the third fluid free to flow on the outside of the shell, or as a shell and tube-in-tube, with a central tube containing a first liquid, a second tube containing a second liquid, and an outer shell containing the third liquid. The selectively permeable tube may include an anion or cation selectively permeable layer and this layer may be supported by a support layer or tube.

Abstract: A debris shield system for use with gutters and other water runoff collection systems is disclosed. The debris shield system provides universal fit to various gutter systems and enables easier assembly on-site and simplifies manufacturing. The debris shield system includes various water adhesion and water capture features, which function to slow the flow of water, break surface tension of the water, and encourage the water flow into a gutter or other water runoff system.

Abstract: Elastic connection pools for database nodes are described. A system receives a user request that references data in a database, and uses the user request to identify a partition of multiple partitions of the database. The system uses the identified partition to identify a database node in a cluster of database nodes. The system uses the identified database node to identify a connection pool of multiple connection pools provided by an application server. If the identified connection pool does not have any available connections to the identified database node, the system uses connection criteria to select another connection pool of the remainder of the connection pools. The system enables the user request to access the referenced data in the identified partition of the database by providing the user request with an available connection, from the other connection pool, to another database node in the cluster.

Abstract: Techniques and structures to prevent exhaustion of a database connection pool, including retrieving data from the database connection pool, monitoring the data to determine whether the connection pool is at risk of an exhaustion condition, analyzing the data to determine whether one or more clients accessing the database connection pool are offenders upon determining that the connection pool is at risk and throttling access to the one or more clients accessing the database connection pool upon determining the one or more clients to be offenders.

Abstract: A debris shield system for use with gutters and other water runoff collection systems is disclosed. The debris shield system provides universal fit to various gutter systems and enables easier assembly on-site and simplifies manufacturing. The debris shield system includes various water adhesion and water capture features, which function to slow the flow of water, break surface tension of the water, and encourage the water flow into a gutter or other water runoff system.

Abstract: Techniques and structures to facilitate automatic adjustment of a database connection pool, including calculating a first value indicating a number of connections of to be provided by a first of a plurality of application servers, determining whether the first value is equal to a second value previously calculated to indicate the number of connections to be provided by the first application server and adjusting the database connection pool by providing the number of connections to access the database as indicated by the first value upon a determination that the first value is not equal to the second value

Abstract: A hermetically sealed filtered feedthrough for an active implantable medical device includes a first conductive leadwire extending from a first end to a second end, the first leadwire second end extending outwardly beyond the device side of an insulator hermetically sealed to a ferrule for the feedthrough. A circuit board supporting a chip capacitor is disposed adjacent to a device side of the insulator and has a circuit board passageway. The first leadwire first end resides in the circuit board passageway. A second conductive leadwire on the device side has a second leadwire first end disposed in the circuit board passageway with a second leadwire second end extending outwardly beyond the circuit board to be connectable to AIMD internal electronics. The second leadwire first end is connected to the first leadwire first end and a capacitor internal metallization in the circuit board passageway.