Abstract: The present application describes a thyroid hormone receptor ? subtype agonist derivative, a preparation method and a use thereof.

Abstract: Disclosed are a compound of Formula I, stereoisomers, pharmaceutically acceptable salts and deuterated compounds thereof and a method for treating, inhibiting and/or preventing a disease or disorder in a subject in need thereof: wherein A, R, G, Y and n are defined as in the present disclosure.

Abstract: A pharmaceutical composition comprising: a compound of formula (1) and a polymer material, wherein the compound of formula (1) maintains a supersaturated concentration in the pharmaceutical composition and is suitable for storage at room temperature.

Abstract: Certain anti-viral compounds, pharmaceutical compositions, and methods related thereto are disclosed.

Abstract: Certain antiviral compounds, pharmaceutical compositions, and methods related thereto are disclosed.

Abstract: Certain anti-viral compounds, pharmaceutical compositions, and methods related thereto are disclosed.

Abstract: A ground-engaging device that is capable of sustained rolling, stable braking, secure standing, and walking. In one preferred embodiment, the invention relates to a wheeled footwear device. In another preferred embodiment, the invention relates to a wheeled footwear platform. In yet another preferred embodiment, the invention relates to a wheeled artificial foot.

Abstract: Certain anti-viral compounds, pharmaceutical compositions, and methods related thereto are disclosed.

Abstract: Embodiments described herein provide a method and system for generating a reading interface for a user. The method includes receiving a first text passage from a first data source and a second text passage from a second data source. The method also includes generating a candidate question relating to contents of the first and the second text passages. The method further includes generating a first answer to the candidate question and a second answer to the candidate question. The method further includes determining that the candidate question qualifies as a discord question when the first answer and the second answer are both available and exhibit semantic diversity. The method further includes constructing a reading interface comprising a first component displaying the discord question and one or more user-engageable components each displaying the first or the second answer and linking to the first or the second data source, respectively.

Abstract: An example process for placing virtual objects in an environment includes: displaying a first view of the environment, the first view including a virtual object displayed at a first location on a first surface of the environment, the first location corresponding to a current location of the electronic device; detecting movement of the electronic device from the current location to an updated location; in accordance with detecting the movement from the current location to the updated location: displaying a second view of the environment, the second view including the virtual object displayed at a second location on the first surface of the environment, the second location corresponding to the updated location; and receiving user input to place the virtual object; and in response to receiving the user input, placing the virtual object at the second location.

Abstract: Pharmaceutical compositions suitable for long-term storage at room temperature are described. The pharmaceutical composition comprises the compound of formula (I) and can be used for the treatment of steatohepatitis. Also described are methods for preparing the pharmaceutical composition and methods of treatment using the pharmaceutical compositions.

Abstract: Disclosed are crystal of thyroid hormone ? receptor agonist, process for preparing the same and use thereof. The crystal with basically no hygroscopicity, a relatively small crystal particle size and a relatively large drug specific surface area can improve the dissolution rate of drugs, is beneficial to the absorption of drugs and improves the bioavailability.

Abstract: A method for preparing the cyclic phosphonate compound of Formula I is described. The method significantly improves the stereoselectivity of the compound with the required configuration.

Abstract: Pharmaceutical compositions suitable for long-term storage at room temperature are described. The pharmaceutical composition comprises the compound of formula (1) and can be used for the treatment of steatohepatitis. Also described are methods for preparing the pharmaceutical composition and methods of treatment using the pharmaceutical compositions.

Abstract: A catalytic converter system having oxygen storage materials is disclosed and methods for determining whether to reactivate oxygen storage materials and monitoring failure events of the oxygen storage materials are also disclosed.

Abstract: Certain anti-viral compounds, pharmaceutical compositions, and methods related thereto are disclosed.

Abstract: Methods and systems are provided for an emissions aftertreatment device. In one example, the emissions aftertreatment device may include a catalyst and a high entropy oxygen storage material formed of at least five metal oxides in equal molar proportions. The at least five metal oxides includes one or more rare earth metals as well as other metals with similar chemical properties as the rare earth metals.

Abstract: Certain anti-viral compounds, pharmaceutical compositions, and methods related thereto are disclosed.

Abstract: A method for quantitatively evaluating the expected ultrasonic inspectability of a designed part using ray tracing. First, a model of a part imported. Materials having different indices of refraction are selected for the part and an acoustic coupling medium. Then the following structures and positional relationships are defined: an ultrasonic transducer array comprising a plurality of elements, a position of the acoustic coupling medium between the transducer array and the part, and a plurality of positions of a transmit aperture relative to the part. For each defined position of the transmit aperture, a path of a respective ray is traced from a center of the transmit aperture through the part and then to a respective receive location on the transducer array. Also, a respective value of an inspectability margin is calculated based at least in part on a respective distance between a center of the receive aperture and the respective receive location.

Abstract: A catalytic converter system having oxygen storage materials is disclosed and methods for determining whether to reactivate oxygen storage materials and monitoring failure events of the oxygen storage materials are also disclosed.