Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for performing protein design. In one aspect, a method comprises: processing an input characterizing a target protein structure of a target protein using an embedding neural network having a plurality of embedding neural network parameters to generate an embedding of the target protein structure of the target protein; determining a predicted amino acid sequence of the target protein based on the embedding of the target protein structure, comprising: conditioning a generative neural network having a plurality of generative neural network parameters on the embedding of the target protein structure; and generating, by the generative neural network conditioned on the embedding of the target protein structure, a representation of the predicted amino acid sequence of the target protein.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for generating a final progression score characterizing a likelihood that a state of a medical condition affecting eye tissue will progress to a target state in a future interval of time. In one aspect, a method comprises: obtaining: (i) an input image of eye tissue captured using an imaging modality, and (ii) a segmentation map of the eye tissue in the input image into a plurality of tissue types; providing the input image to each of one or more first classification neural networks to obtain a respective first progression score from each first classification neural network; providing the segmentation map to each of one or more second classification neural networks to obtain a respective second progression score from each second classification neural network; and generating the final progression score based on the first and second progression scores.

Abstract: A device for spinal surgery that may be used for tightening a locking cap onto at least a portion of a pedicle screw. The device may include a torque-generating body having a proximal end and an opposing distal end and a drive shaft rotatably driven by the torque-generating body. A proximal end of the drive shaft may be operatively engaged to the distal end of the torque-generating body and an opposing distal end of the drive shaft may engage at least a portion of one of the locking cap and the pedicle screw. An anti-torque device is provided that has an elongated and generally hollow member defining a longitudinal axis. The member has a proximal end and an opposing distal end, where the proximal end of the anti-torque device may be fixed from rotating relative to at least a portion of the torque-generating body and the distal end may be fixed from rotating relative to a spine rod or a pedicle screw.

Abstract: A device for spinal surgery that may be used for tightening a locking cap onto at least a portion of a pedicle screw. The device may include a torque-generating body having a proximal end and an opposing distal end and a drive shaft rotatably driven by the torque-generating body. A proximal end of the drive shaft may be operatively engaged to the distal end of the torque-generating body and an opposing distal end of the drive shaft may engage at least a portion of one of the locking cap and the pedicle screw. An anti-torque device is provided that has an elongated and generally hollow member defining a longitudinal axis. The member has a proximal end and an opposing distal end, where the proximal end of the anti-torque device may be fixed from rotating relative to at least a portion of the torque-generating body and the distal end may be fixed from rotating relative to a spine rod or a pedicle screw.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for generating a final progression score characterizing a likelihood that a state of a medical condition affecting eye tissue will progress to a target state in a future interval of time. In one aspect, a method comprises: obtaining: (i) an input image of eye tissue captured using an imaging modality, and (ii) a segmentation map of the eye tissue in the input image into a plurality of tissue types; providing the input image to each of one or more first classification neural networks to obtain a respective first progression score from each first classification neural network; providing the segmentation map to each of one or more second classification neural networks to obtain a respective second progression score from each second classification neural network; and generating the final progression score based on the first and second progression scores.

Abstract: An augmented reality (AR) game system is disclosed wherein real-world objects are transformed into AR terrain elements and AR events generate real-world impact. The game environment is set up using real-world objects that include everyday objects and game pieces on a field of play. When viewed on the screen of a computing device executing the modules of the game system, the everyday objects are transformed into elements of an AR terrain while the game pieces can be augmented with various controls. Multiple viewing modes, for example, a third person view, a first person view or “POV” view from a selected game piece or a split screen view are contemplated for viewing the field of play. A subset of the augmented controls can be activated by the user to execute AR events some of which can have real-world impact. The AR events are executed based on game rules.

Abstract: An augmented reality (AR) game system is disclosed wherein real-world objects are transformed into AR terrain elements and AR events generate real-world impact. The game environment is set up using real-world objects that include everyday objects and game pieces on a field of play. When viewed on the screen of a computing device executing the modules of the game system, the everyday objects are transformed into elements of an AR terrain while the game pieces can be augmented with various controls. Multiple viewing modes, for example, a third person view, a first person view or “POV” view from a selected game piece or a split screen view are contemplated for viewing the field of play. A subset of the augmented controls can be activated by the user to execute AR events some of which can have real-world impact. The AR events are executed based on game rules.

Abstract: Embodiments of a bony structure tap with a plurality of landmarks. Other embodiments may be described and claimed.

Abstract: Embodiments of systems to dynamically provide therapy to user by providing real time streaming of seminars based a therapy schedule, the therapy schedule based a user demographic database and feedback database.

Abstract: An augmented reality (AR) game system is disclosed wherein real-world objects are transformed into AR terrain elements and AR events generate real-world impact. The game environment is set up using real-world objects that include everyday objects and game pieces on a field of play. When viewed on the screen of a computing device executing the modules of the game system, the everyday objects are transformed into elements of an AR terrain while the game pieces can be augmented with various controls. Multiple viewing modes, for example, a third person view, a first person view or “POV” view from a selected game piece or a split screen view are contemplated for viewing the field of play. A subset of the augmented controls can be activated by the user to execute AR events some of which can have real-world impact. The AR events are executed based on game rules.

Abstract: Embodiments of systems and methods that dynamically provide users with training/seminar presentations or direct users to attend specific training or seminars based on user demographics, other user demographics and results metrics. Embodiments of systems and methods that predict a user's potential progress when compliant or based on measured compliance with seminar participation based on other user demographics, other users' results metrics, health or training profession's analysis, and the user's result metrics before, after, and while participating in the seminars. Embodiments of systems and methods that determine a user's results or metric based on a combination of inputs including user subjective and objective data or input and health or training profession's analysis. Other embodiments may be described and claimed.

Abstract: An augmented reality (AR) game system is disclosed wherein real-world objects are transformed into AR terrain elements and AR events generate real-world impact. The game environment is set up using real-world objects that include everyday objects and game pieces on a field of play. When viewed on the screen of a computing device executing the modules of the game system, the everyday objects are transformed into elements of an AR terrain while the game pieces can be augmented with various controls. Multiple viewing modes, for example, a third person view, a first person view or “POV” view from a selected game piece or a split screen view are contemplated for viewing the field of play. A subset of the augmented controls can be activated by the user to execute AR events some of which can have real-world impact. The AR events are executed based on game rules.

Abstract: A game piece with a moveable base for use in an augmented reality (AR) game system is disclosed An object recognizing computing device enforces game rules. A main body is configured for unique, visible object recognition by the object recognizing computing device. A motorized base is detachably and re-attachably coupled to the main body and in communication with said transceiver, the base configured to physically move the game piece over a distance on a field of play from a first position on the field of play to a second position on the field of play in response to receiving an actuating signal from the processor. The game environment is set up using real-world objects that include everyday objects and a plurality of game pieces on a field of play.

Abstract: A device for spinal surgery that may be used for tightening a locking cap onto at least a portion of a pedicle screw. The device may include a torque-generating body having a proximal end and an opposing distal end and a drive shaft rotatably driven by the torque-generating body. A proximal end of the drive shaft may be operatively engaged to the distal end of the torque-generating body and an opposing distal end of the drive shaft may engage at least a portion of one of the locking cap and the pedicle screw. An anti-torque device is provided that has an elongated and generally hollow member defining a longitudinal axis. The member has a proximal end and an opposing distal end, where the proximal end of the anti-torque device may be fixed from rotating relative to at least a portion of the torque-generating body and the distal end may be fixed from rotating relative to a spine rod or a pedicle screw.

Abstract: An augmented reality (AR) game system is disclosed wherein real-world objects are transformed into AR terrain elements and AR events generate real-world impact. The game environment is set up using real-world objects that include everyday objects and game pieces on a field of play. When viewed on the screen of a computing device executing the modules of the game system, the everyday objects are transformed into elements of an AR terrain while the game pieces can be augmented with various controls. Multiple viewing modes, for example, a third person view, a first person view or “POV” view from a selected game piece or a split screen view are contemplated for viewing the field of play. A subset of the augmented controls can be activated by the user to execute AR events some of which can have real-world impact. The AR events are executed based on game rules. Detection mechanisms such as colored detection can be used for detecting positions of game pieces within the field of play.

Abstract: An augmented reality (AR) game system is disclosed wherein real-world objects are transformed into AR terrain elements and AR events generate real-world impact. The game environment is set up using real-world objects that include everyday objects and game pieces on a field of play. When viewed on the screen of a computing device executing the modules of the game system, the everyday objects are transformed into elements of an AR terrain while the game pieces can be augmented with various controls. Multiple viewing modes, for example, a third person view, a first person view or “POV” view from a selected game piece or a split screen view are contemplated for viewing the field of play. A subset of the augmented controls can be activated by the user to execute AR events some of which can have real-world impact. The AR events are executed based on game rules.

Abstract: An augmented reality (AR) game system is disclosed wherein real-world objects are transformed into AR terrain elements and AR events generate real-world impact. The game environment is set up using real-world objects that include everyday objects and game pieces on a field of play. When viewed on the screen of a computing device executing the modules of the game system, the everyday objects are transformed into elements of an AR terrain while the game pieces can be augmented with various controls. Multiple viewing modes, for example, a third person view, a first person view or “POV” view from a selected game piece or a split screen view are contemplated for viewing the field of play. A subset of the augmented controls can be activated by the user to execute AR events some of which can have real-world impact. The AR events are executed based on game rules.

Abstract: An augmented reality (AR) game system is disclosed wherein real-world objects are transformed into AR terrain elements and AR events generate real-world impact. The game environment is set up using real-world objects that include everyday objects and game pieces on a field of play. When viewed on the screen of a computing device executing the modules of the game system, the everyday objects are transformed into elements of an AR terrain while the game pieces can be augmented with various controls. Multiple viewing modes, for example, a third person view, a first person view or “POV” view from a selected game piece or a split screen view are contemplated for viewing the field of play. A subset of the augmented controls can be activated by the user to execute AR events some of which can have real-world impact. The AR events are executed based on game rules.

Abstract: Embodiments of systems to dynamically provide therapy to user by providing real time streaming of seminars based a therapy schedule, the therapy schedule based a user demographic database and feedback database.

Abstract: A game piece with a moveable base for use in an augmented reality (AR) game system is disclosed An object recognizing computing device enforces game rules. A main body is configured for unique, visible object recognition by the object recognizing computing device. A motorized base is detachably and re-attachably coupled to the main body and in communication with said transceiver, the base configured to physically move the game piece over a distance on a field of play from a first position on the field of play to a second position on the field of play in response to receiving an actuating signal from the processor. The game environment is set up using real-world objects that include everyday objects and a plurality of game pieces on a field of play.