Abstract: Disclosed herein are compounds useful for the inhibition of STAT6. The compounds have a general Formula (I) or (II) or pharmaceutically acceptable salts thereof, wherein the variables of Formula (I) and (II) are as defined herein. Also provided herein are pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, diseases/disorders related to the activity of STAT6, such as an allergic disease or an inflammatory disease, including but not limited to atopic dermatitis or bronchial asthma. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I) and (II).

Abstract: A platform and method for testing antibiotic sensitivity of a polymicrobial infection is provided. The platform includes a body defining a plurality of sets of chambers and a plurality of wells. Each set of chambers has a plurality of chambers adapted for culturing microbes of the polymicrobial infection therein. Each well is associated with a corresponding set of chambers and has an input in fluidic communication with the outlets of the plurality of chambers in the corresponding set of chambers. Selected antibiotic therapies may be received in the wells which fluidically connect the plurality of chambers in a corresponding set of chambers such that microbes cultured in the plurality of chambers in the corresponding set of chambers are in soluble factor contact.

Abstract: According to an aspect, there is provided an electrical socket system comprising: an electrical socket comprising at least one temperature sensor; and a controller configured to monitor a temperature sensed by the temperature sensor, wherein the controller is configured to: determine a temperature gradient of the temperature with respect to time; determine if the temperature gradient exceeds a threshold gradient value; and trigger an alarm event if it is determined that the temperature gradient exceeds the threshold gradient value.

Abstract: According to an aspect, there is provided an electrical socket system comprising: an electrical socket comprising at least one temperature sensor; and a controller configured to monitor a temperature sensed by the temperature sensor, wherein the controller is configured to: determine a temperature gradient of the temperature with respect to time; determine if the temperature gradient exceeds a threshold gradient value; and trigger an alarm event if it is determined that the temperature gradient exceeds the threshold gradient value.

Abstract: A platform and method for testing antibiotic sensitivity of a polymicrobial infection is provided. The platform includes a body defining a plurality of sets of chambers and a plurality of wells. Each set of chambers has a plurality of chambers adapted for culturing microbes of the polymicrobial infection therein. Each well is associated with a corresponding set of chambers and has an input in fluidic communication with the outlets of the plurality of chambers in the corresponding set of chambers. Selected antibiotic therapies may be received in the wells which fluidically connect the plurality of chambers in a corresponding set of chambers such that microbes cultured in the plurality of chambers in the corresponding set of chambers are in soluble factor contact.

Abstract: A method for forming a semiconductor arrangement is provided. The method includes forming a patterned photoresist over a top surface of a substrate. The method includes doping a first portion of the substrate using the patterned photoresist. The method includes removing the patterned photoresist using a gas comprising fluoride, wherein fluoride residue from the gas remains on the top surface of the substrate after removing the patterned photoresist. The method includes treating the substrate with nitrous oxide to remove the fluoride residue.

Abstract: A platform and method for testing antibiotic sensitivity of a polymicrobial infection is provided. The platform includes a body defining a plurality of sets of chambers and a plurality of wells. Each set of chambers has a plurality of chambers adapted for culturing microbes of the polymicrobial infection therein. Each well is associated with a corresponding set of chambers and has an input in fluidic communication with the outlets of the plurality of chambers in the corresponding set of chambers. Selected antibiotic therapies may be received in the wells which fluidically connect the plurality of chambers in a corresponding set of chambers such that microbes cultured in the plurality of chambers in the corresponding set of chambers are in soluble factor contact.

Abstract: According to an aspect, there is provided an electrical socket system comprising: an electrical socket comprising at least one temperature sensor; and a controller configured to monitor a temperature sensed by the temperature sensor, wherein the controller is configured to: determine a temperature gradient of the temperature with respect to time; determine if the temperature gradient exceeds a threshold gradient value; and trigger an alarm event if it is determined that the temperature gradient exceeds the threshold gradient value.

Abstract: According to an aspect, there is provided an electrical socket system comprising: an electrical socket comprising at least one temperature sensor; and a controller configured to monitor a temperature sensed by the temperature sensor, wherein the controller is configured to: determine a temperature gradient of the temperature with respect to time; determine if the temperature gradient exceeds a threshold gradient value; and trigger an alarm event if it is determined that the temperature gradient exceeds the threshold gradient value.

Abstract: A method for forming a semiconductor arrangement is provided. The method includes forming a patterned photoresist over a top surface of a substrate. The method includes doping a first portion of the substrate using the patterned photoresist. The method includes removing the patterned photoresist using a gas comprising fluoride, wherein fluoride residue from the gas remains on the top surface of the substrate after removing the patterned photoresist. The method includes treating the substrate with nitrous oxide to remove the fluoride residue.

Abstract: According to an aspect, there is provided an electrical socket system comprising: an electrical socket comprising at least one temperature sensor; and a controller configured to monitor a temperature sensed by the temperature sensor, wherein the controller is configured to: determine a temperature gradient of the temperature with respect to time; determine if the temperature gradient exceeds a threshold gradient value; and trigger an alarm event if it is determined that the temperature gradient exceeds the threshold gradient value.

Abstract: Embodiments of the disclosure provide systems and methods for measuring performance of a web page and elements of the web page. According to one embodiment, web page performance measurement can comprise initiating measurement of performance of a web page rendered by a client device. The web page can comprise a plurality of elements and the plurality of elements can comprise at least one Web Component element. Performance of the web page can be monitored based on interaction with the client device and one or more performance metrics for each of the elements of the web page receive can be received from the client device. A set of performance metrics for the web page can be maintained. The set of performance metrics can comprise server-side performance metrics based on the monitoring of the performance of the web page and client-side performance metrics received from the client device.

Abstract: A platform and method for testing antibiotic sensitivity of a polymicrobial infection is provided. The platform includes a body defining a plurality of sets of chambers and a plurality of wells. Each set of chambers has a plurality of chambers adapted for culturing microbes of the polymicrobial infection therein. Each well is associated with a corresponding set of chambers and has an input in fluidic o communication with the outlets of the plurality of chambers in the corresponding set of chambers. Selected antibiotic therapies may be received in the wells which fluidically connect the plurality of chambers in a corresponding set of chambers such that microbes cultured in the plurality of chambers in the corresponding set of chambers are in soluble factor contact.

Abstract: A power adapter includes a primary side and a secondary side. The primary side rectifies an alternating current voltage. The secondary side is coupled to the primary side, provides a direct current voltage of a specific voltage level to a cable. The second side includes a sensing resistor, and a compensation circuit. The compensation circuit monitors a voltage level across the sensing resistor, and injects a current into the cable based on the voltage level across the sensing resistor.

Abstract: A power adapter includes a primary side and a secondary side. The primary side rectifies an alternating current voltage. The secondary side is coupled to the primary side, provides a direct current voltage of a specific voltage level to a cable. The second side includes a sensing resistor, and a compensation circuit. The compensation circuit monitors a voltage level across the sensing resistor, and injects a current into the cable based on the voltage level across the sensing resistor.

Abstract: A film capacitor comprising (1) of electric conduction electrodes and (2) of semi-crystalline polymeric dielectric film(s), the thickness of which ranges from 1 micron to 80 micron, made by a melt-stretching extrusion process through a die (circular die or flat die) with a drawdown ratio of 30 or higher (the ratio of die gap to the film thickness) at die temperatures higher than the melting point of said semi-crystalline polymer(s). The semi-crystalline polymeric dielectric films made by such melt-stretching extrusion process show a significantly low shrinkage at high temperatures until they are melted. The capacitor comprising such low shrinkage film dielectrics can be used at a much higher temperature than comprising conventional biaxially oriented film dielectrics made of the same plastic materials.

Abstract: A rotary disk for an image-changing light device includes a metal disk body adapted to be disposed in the light device. The disk body is formed by two disk halves coupled detachably with each other, and a plurality of colored lenses. Each of the disk halves is pressed to form a circle of angularly spaced recess units and is punched to form a circle of openings through the disk half. Each of the recess units is defined by a bottom wall unit through a portion of which a corresponding one of the openings is formed so that the light beam emitted from a light emitting unit of the light device can pass through the openings when the disk rotates. Each of the lenses is clamped between the bottom wall units of the disk halves in such a manner that a portion of the lens is fitted within a corresponding one of the recess units of one of the disk halves while another portion of the lens is fitted within a corresponding one of the recess units of the other one of the disk halves.

Abstract: A control apparatus capable of resetting a shielding wheel of a stepwise light projecting device to a predetermined starting position includes a photosensor, a slotted wheel and a control circuit unit. The device includes a stepping motor, an output shaft which extends outwardly from front and rear lateral walls of the motor, and the shielding wheel fixed to a front end of the shaft. The photosensor includes a phototransmitter and a photoreceiver spaced from the phototransmitter to define a channel therebetween. The slotted wheel is mounted on a rear end of the shaft, and has a circumferential portion that extends into the channel and that is formed with a radial slot to permit transmission of radiant energy from the phototransmitter to the protoreceiver only when the shielding wheel is in the starting position.

Abstract: A light emitting apparatus includes a first stepper motor, a mounting frame, a second stepper motor, at least one reflector, and a light source. The first stepper motor has a first rotor and a first output shaft coupled to and driven by the first rotor. The frame is fixed to and rotates together with the first output shaft. The second stepper motor has a second rotor and a second output shaft coupled to and driven by the second rotor. The second stepper motor is mounted on the mounting frame such that the second output shaft is transverse to the first output shaft and is rotatable relative to the mounting frame. The reflector is fixed to and rotates with the second output shaft, and has a light reflecting surface and a plurality of differently colored reflecting facets disposed around an axis of the second output shaft and on the reflecting surface.

Abstract: A coaxial cable includes a coaxial wire having a central conductor, an outer conductor, an inner insulating layer between said central and outer conductors and an outer insulating layer covering said outer conductor. A hollow metal tube has an inner wall, a first end and a second end which is restricted and press-formed to possess a polygonal wall surface tightly receiving the outer conductor of the coaxial wire when the latter is inserted into the metal tube. The metal tube further has a stop member adjacent to the first end. A plug member is inserted into the first end of the hollow metal tube where the stop member limits the movement of the plug member in the metal tube. The first end of the metal tube is in electrical contact with an annular electric conducting wall of the plug member, and a central electric conducting blade axially extends into the metal tube and electrically contacts the central conductor of the coaxial wire.