Abstract: A package substrate may include a circuit and a leaky surface wave launcher. The circuit may perform engineering tests and end-user operations using sideband signals. The leaky surface wave launcher may perform near field wireless communication. The leaky surface wave launcher may include a via and a strip line. The via may be electrically coupled to the circuit. The via may provide the sideband signals to and receive the sideband signals from the circuit. The strip line may be electrically coupled to the via. The strip line may be excited by the sideband signals to wirelessly couple the leaky surface wave launcher with an external device. The strip line and the via may be unbalanced such that the strip line generates a leaky wave that propagates at least a portion of the package substrate and an environment proximate the package substrate.

Abstract: An ice making assembly includes a mold body defining an ice-making cavity. An evaporator is coupled to the mold body. The evaporator includes a cap positioned on the mold body such that an open end of the cap is positioned at the mold body. An inlet tube is mounted to the cap. An outlet tube is also mounted to the cap. An evaporation chamber is formed between the cap and the mold body. The inlet tube is configured for directing a flow of refrigerant into the evaporation chamber, and the outlet tube configured for directing the flow of refrigerant out of the evaporation chamber.

Abstract: An alternating pressure fatigue test system for a high-speed train based on an internal root pump loading mechanism includes a train body; a first tube having one end forming a gas output opening and a second tube having one end forming a gas input opening; another end of the first tube and another end of the second tube being connected to each other to form a third joint; a connective tube connected to a first joint on the first tube and a second joint on the second tube and being installed with at least one root pump; a first isolation valve and a third isolation valve installed in the first tube; a second isolation valve and a fourth isolation valve installed in the second tube; and at least one transferring tube connected between the third joint and the train body.

Abstract: It may be desirable for a remote advisor to request an autonomous vehicle to relocate to a target relocation pose using a freespace planner that has fewer constraints than the structured planner that is used for normal driving. The autonomous vehicle planning stack can include a remote vehicle interface, which can serve as the application programming interface for remote requestors to request relocation of the autonomous vehicle. The remote vehicle interface may implement a relocation state machine to carry out different parts of a relocation session. A scenario manager may subscribe to the state of the relocation state machine. Based on the state, the scenario manager can request the freespace planner to generate an output plan for the target relocation pose and can orchestrate handoff between different motion planners to relocate the autonomous vehicle.

Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

Abstract: A majority of neuroendocrine (NE) cancers overexpress somatostatin receptors (SSTRs). Disclosed herein are anti-SSTR2 monoclonal antibodies, and antibody-drug conjugates (ADCs) for use as NE cancer targeting therapeutics. Also disclosed is an isolated nucleic acid encoding the disclosed antibodies, as well as nucleic acid vectors containing this isolated nucleic acid operably linked to an expression control sequence. Also disclosed are cells transfected with these vectors and the use of these cells to produce the disclosed recombinant antibodies. Also disclosed is a method of treating a neuroendocrine (NE) cancer in a subject, comprising administering to the subject an effective amount of the disclosed antibody conjugated to an anti-cancer agent.

Abstract: HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.

Abstract: A system and method for appliance communication is provided. The method includes connecting an initially-connected device to a server via a network; initiating, at a first appliance, a first appliance registration process; detecting, via the first appliance, a communications signal from a second appliance; communicatively coupling the second appliance to the server via the initially-connected device; and transmitting second appliance registration data from the second appliance to the server via communicative coupling of the second appliance to the initially-connected device connected to the network.

Abstract: Described herein are methods of purifying nucleic acids (e.g., mRNAs) from feed solutions using continuous, multicolumn chromatography approaches. Also described are methods of increasing the efficiency of chromatography methods by performing purification methods in parallel using multiple columns.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.

Abstract: According to examples, systems and methods for implementing a conductive trace via laser direct structuring (LDS) and a light-emitting diode (LED) via surface-mount technology (SMT) on a carrier structure of a display device are described. A method may include printing a conductive trace onto a carrier, mounted a light-emitting diode (LED) onto the carrier, and attaching a flexible printed circuit (FPC) to the carrier, wherein the light-emitting diode (LED) is communicatively coupled to the flexible printed circuit (FPC) via the conductive trace.

Abstract: Load management of chargers at a charging site is provided in which one or more processors coupled with memory can identify a setting for a first charger and a second charger that can be coupled with a phase line of an electrical panel to conduct power at a first phase. The one or more processors can determine that the phase line is configured to operate below a phase line capacity of the phase line while the first charger coupled with the phase line operates at a charger capacity of the first charger. The one or more processors can cause the first charger to operate at the charger capacity according to the setting in response to determining that the phase line is configured to operate below the phase line capacity while the first charger coupled with the phase line operates at the charger capacity.

Abstract: A clamping device includes an installation plate and a pair of clamping claws installed on the installation plate. One of the clamping claws has a first clamping surface and the other has a second clamping surface. The first clamping surface contacts a side of a fixed part of the elastic contact member and a row of first elastic arms. The second clamping surface contacts another side of the fixed part and a row of second elastic arms. The first clamping surface matches an outer surface of the side of the fixed part and a plurality of outer surfaces of the row of first elastic arms, the second clamping surface matches an outer surface of the other side of the fixed part and a plurality of outer surfaces of the row of second elastic arms. A clamping force applied by the clamping claws is evenly distributed on the elastic contact member.

Abstract: An example method for training a machine-learned sequence processing model includes obtaining a plurality of training examples for training the machine-learned sequence processing model. For each respective training example of the plurality of training examples, the example method includes: obtaining a respective query associated with the respective training example; inputting the respective query to the machine-learned sequence processing model; obtaining, from the machine-learned sequence processing model a response to the respective query and a trace of intermediate states from the respective query to the response; evaluating the response using a ground truth response associated with the respective training example; evaluating the trace using a ground truth trace associated with the respective training example; and updating one or more parameters of the machine-learned sequence processing model based on the evaluation of the response and based on the evaluation of the trace.

Abstract: A gastrostomy tube for insertion through an abdomen and into a stomach, including a cylindrical outer tube including a first proximal opening and a first distal opening, a flange surrounding the first proximal opening of the outer tube, a detachable cylindrical inner tube including a second proximal opening and a second distal opening, and one or more spokes attached to a distal end of the gastrostomy tube, wherein the one or more spokes include an actuatable portion configured to rotate the one or more spokes between a retracted position and an expanded position, wherein the inner tube is insertable into the first proximal opening of the outer tube, wherein the one or more spokes are rotatable into the expanded position when the inner tube is inserted through the first distal opening of the outer tube, and wherein the one or more spokes are substantially perpendicular to the outer tube in the expanded position.

Abstract: An engine hood insulator is provided. The engine hood insulator includes an insulating layer and a plurality of first elastic connecting elements coupled with the insulating layer. The first elastic connecting elements are detachably connected with a plurality of second connecting elements disposed on a lower surface of the engine hood.

Abstract: A window switch assembly of a vehicle comprises a base; a rail on the base; and a control member partially received in the rail and slidable in the rail. The rail includes a first rail body extending at a traverse direction, a first end portion and a second end portion communicated with the first rail body. The first end portion includes a first switch and a second switch opposite each other in a longitudinal direction, and the second end portion includes a third switch and a fourth switch opposite each other in the longitudinal direction. The control member selectively contacts the first switch and the second switch to control a first window, and selectively contacts the third switch and the fourth switch to control a second window.