Patents by Inventor Jasper Clube
Jasper Clube has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11578333Abstract: The invention relates to the production and use of Cas-encoding sequences and vectors comprising these. Aspects of the invention provide products, vectors, delivery vehicles, uses and methods for producing Cas-encoding sequences in bacterial or archaeal cells.Type: GrantFiled: March 8, 2021Date of Patent: February 14, 2023Assignee: SNIPR Biome ApSInventors: Virginia Martinez, Ruben Vazquez-Uribe, Adam Takos, Eric Van Der Helm, Jasper Clube
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Patent number: 11547716Abstract: The invention relates to methods, uses, systems, arrays, engineered nucleotide sequences and vectors for inhibiting bacterial population growth or for altering the relative ratio of sub-populations of first and second bacteria in a mixed population of bacteria. The invention is particularly useful, for example, for treatment of microbes such as for environmental, medical, food and beverage use The invention relates infer alio to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system.Type: GrantFiled: May 20, 2022Date of Patent: January 10, 2023Assignee: SNIPR Technologies LimitedInventor: Jasper Clube
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Patent number: 11517582Abstract: The invention relates to methods, uses, systems, arrays, engineered nucleotide sequences and vectors for inhibiting bacterial population growth or for altering the relative ratio of sub-populations of first and second bacteria in a mixed population of bacteria. The invention is particularly useful, for example, for treatment of microbes such as for environmental, medical, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system.Type: GrantFiled: April 4, 2017Date of Patent: December 6, 2022Assignee: SNIPR TECHNOLOGIES LIMITEDInventors: Jasper Clube, Morten Sommer, Christian Grøndahl, Eric Van Der Helm, Ruben Vanquez-Uribe
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Publication number: 20220362280Abstract: The invention relates to methods, uses, systems, arrays, engineered nucleotide sequences and vectors for inhibiting bacterial population growth or for altering the relative ratio of sub-populations of first and second bacteria in a mixed population of bacteria. The invention is particularly useful, for example, for treatment of microbes such as for environmental, medical, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system.Type: ApplicationFiled: May 20, 2022Publication date: November 17, 2022Applicant: SNIPR Technologies LimitedInventor: Jasper CLUBE
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Patent number: 11485973Abstract: The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease.Type: GrantFiled: September 23, 2020Date of Patent: November 1, 2022Assignee: SNIPR Biome ApSInventors: Morten Sommer, Virginia Martinez, Eric Van der Helm, Jakob Krause Haaber, Ana De Santiago Torio, Christian Grøndahl, Jasper Clube
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Patent number: 11471531Abstract: The invention relates to methods of modulating immune cells in a patient by altering microbiota of the patient. The invention also relates to methods of modulating treatments or therapies in a subject organism by altering microbiota of the subject. The invention also relates to cell populations, systems, arrays, cells, RNA, kits and other means for effecting this. In an example, advantageously selective targeting of a particular species in a human gut microbiota using guided nucleic acid modification is carried out to effect the alteration.Type: GrantFiled: December 23, 2020Date of Patent: October 18, 2022Assignee: SNIPR Technologies LimitedInventors: Jasper Clube, Morten Sommer, Christian Grøndahl
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Patent number: 11471530Abstract: The invention relates to methods of modulating immune cells in a patient by altering microbiota of the patient. The invention also relates to methods of modulating treatments or therapies in a subject organism by altering microbiota of the subject. The invention also relates to cell populations, systems, arrays, cells, RNA, kits and other means for effecting this. In an example, advantageously selective targeting of a particular species in a human gut microbiota using guided nucleic acid modification is carried out to effect the alteration.Type: GrantFiled: April 19, 2019Date of Patent: October 18, 2022Assignee: SNIPR Technologies LimitedInventor: Jasper Clube
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Patent number: 11453726Abstract: The invention relates to multimers such as tetramers of polypeptides and tetramers and octamers of effector domains, such as antigen binding sites (eg, antibody or TCR binding sites that specifically bind to antigen or pMHC, or variable domains thereof) or peptides such as incretin, insulin or hormone peptides.Type: GrantFiled: September 18, 2017Date of Patent: September 27, 2022Assignee: QUADRUCEPT BIO LIMITEDInventors: Hanif Ali, Terence Rabbitts, Christian Grøndahl, Jasper Clube
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Publication number: 20220295765Abstract: The present invention relates to humanisation of antibodies in vivo. The invention provides non-human vertebrates, cells, populations and methods useful for humanising chimaeric antibodies in vivo. Using the present invention, it is possible straightforwardly and rapidly to obtain antigen-specific antibodies that are fully human (i.e., comprising human variable and constant regions) and have undergone recombination, junctional diversification, affinity maturation and isotype switching in vivo in a non-human vertebrate system. Furthermore, such antibodies are humanised (e.g., totally human)—and selected—totally in vivo, and as such the present invention harnesses in vivo filtering for expressibility, affinity and biophysical characteristics in the context of the desired human variable and constant region pairings. This avoids problems of down-grading antibody characteristics when humanising the constant region of chimaeric antibodies in vitro.Type: ApplicationFiled: March 29, 2022Publication date: September 22, 2022Inventor: Jasper Clube
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Publication number: 20220290133Abstract: The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease.Type: ApplicationFiled: May 19, 2022Publication date: September 15, 2022Applicant: SNIPR Biome ApSInventors: Morten SOMMER, Virginia MARTINEZ, Eric VAN DER HELM, Jakob Krause HAABER, Ana DE SANTIAGO TORIO, Christian GRØNDAHL, Jasper CLUBE
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Publication number: 20220287283Abstract: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising the antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in the methods.Type: ApplicationFiled: March 24, 2022Publication date: September 15, 2022Inventors: Allan Bradley, E-Chiang Lee, Qi Liang, Wei Wang, Dominik Spensberger, Hui Liu, Jasper Clube
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Publication number: 20220282245Abstract: The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease.Type: ApplicationFiled: May 20, 2022Publication date: September 8, 2022Applicant: SNIPR Biome ApSInventors: Morten SOMMER, Virginia MARTINEZ, Eric VAN DER HELM, Jakob Krause HAABER, Ana DE SANTIAGO TORIO, Christian GRØNDAHL, Jasper CLUBE
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Publication number: 20220273696Abstract: The invention relates to methods, uses, systems, arrays, engineered nucleotide sequences and vectors for inhibiting bacterial population growth or for altering the relative ratio of sub-populations of first and second bacteria in a mixed population of bacteria. The invention is particularly useful, for example, for treatment of microbes such as for environmental, medical, food and beverage use The invention relates infer alio to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system.Type: ApplicationFiled: May 20, 2022Publication date: September 1, 2022Applicant: SNIPR Technologies LimitedInventor: Jasper CLUBE
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Patent number: 11421227Abstract: The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease.Type: GrantFiled: March 11, 2021Date of Patent: August 23, 2022Assignee: SNIPR Biome ApSInventors: Morten Sommer, Virginia Martinez, Eric Van Der Helm, Jakob Krause Haaber, Ana De Santiago Torio, Christian Grøndahl, Jasper Clube
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Publication number: 20220259588Abstract: The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease.Type: ApplicationFiled: April 25, 2022Publication date: August 18, 2022Applicant: SNIPR Biome ApSInventors: Morten SOMMER, Virginia MARTINEZ, Eric VAN DER HELM, Jakob Krause HAABER, Ana DE SANTIAGO TORIO, Christian GRØNDAHL, Jasper CLUBE
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Publication number: 20220241318Abstract: The invention relates to methods, uses, systems, arrays, engineered nucleotide sequences and vectors for inhibiting bacterial population growth or for altering the relative ratio of sub-populations of first and second bacteria in a mixed population of bacteria. The invention is particularly useful, for example, for treatment of microbes such as for environmental, medical, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system.Type: ApplicationFiled: February 14, 2022Publication date: August 4, 2022Applicant: SNIPR Technologies LimitedInventors: Jasper CLUBE, Morten SOMMER, Christian GRØNDAHL, Eric VAN DER HELM, Ruben VAZQUEZ-URIBE
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Patent number: 11400110Abstract: The invention relates to methods, uses, systems, arrays, engineered nucleotide sequences and vectors for inhibiting bacterial population growth or for altering the relative ratio of sub-populations of first and second bacteria in a mixed population of bacteria. The invention is particularly useful, for example, for treatment of microbes such as for environmental, medical, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system.Type: GrantFiled: November 25, 2020Date of Patent: August 2, 2022Inventor: Jasper Clube
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Patent number: 11399522Abstract: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.Type: GrantFiled: February 19, 2021Date of Patent: August 2, 2022Assignee: Kymab LimitedInventors: E-Chiang Lee, Jasper Clube, Allan Bradley
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Publication number: 20220233575Abstract: The invention relates to methods, uses, systems, arrays, engineered nucleotide sequences and vectors for inhibiting bacterial population growth or for altering the relative ratio of sub-populations of first and second bacteria in a mixed population of bacteria. The invention is particularly useful, for example, for treatment of microbes such as for environmental, medical, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system.Type: ApplicationFiled: August 3, 2021Publication date: July 28, 2022Inventors: Jasper CLUBE, Morten SOMMER, Christian GRØNDAHL, Eric VAN DER HELM, Ruben VAZQUEZ-URIBE
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Publication number: 20220226396Abstract: The invention relates to means for carrying out conjugation between bacteria, and in particular the invention relates to carrier bacteria comprising antimicrobial agents and methods of use. The carrier bacteria are capable of conjugative transfer of DNA encoding the agent to a target cells. The invention further relates to growth or feed conversion ratio promotion in animals. The invention further relates to killing Salmonella or inhibiting the growth or proliferation of Salmonella.Type: ApplicationFiled: May 10, 2020Publication date: July 21, 2022Inventors: Martin WOODWARD, Tristan COGAN, Edward FUCHS, Holger KNEUPER, Alessandro RICCIO, Christian GRØNDAHL, Jasper CLUBE