Patents by Inventor Jasper D. Rine

Jasper D. Rine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AFC1 and RCE1: isoprenylated CAAX processing enzymes
    Patent number: 7029911
    Abstract: Two genes which encode polypeptides that mediate post-prenylation processing steps in CAAX polypeptides such as Ras are provided. The two genes (AFC1 and RCE1) encode polypeptides that mediate the removal of the AAX tripeptide from the CAAX polypeptide following prenylation. The genes and encoded polypeptides provide assays for testing compounds for an effect on post-prenylation processing steps. A heat shock assay for assessing Ras activity is also provided.
    Type: Grant
    Filed: October 2, 1998
    Date of Patent: April 18, 2006
    Assignee: The Regents of the University of California
    Inventors: Jasper D. Rine, Victor L. Boyartchuk, Matthew N. Ashby
  • AFC1 and RCE1: isoprenylated CAAX processing enzymes
    Publication number: 20040072296
    Abstract: Two genes which encode polypeptides that mediate post-prenylation processing steps in CAAX polypeptides such as Ras are provided. The two genes (AFC1 and RCE1) encode polypeptides that mediate the removal of the AAX tripeptide from the CAAX polypeptide following prenylation. The genes and encoded polypeptides provide assays for testing compounds for an effect on post-prenylation processing steps. A heat shock assay for assessing Ras activity is also provided.
    Type: Application
    Filed: August 21, 2003
    Publication date: April 15, 2004
    Inventors: Jasper D. Rine, Victor L. Boyartchuk, Matthew N. Ashby
  • Genes and proteins controlling cholesterol synthesis
    Patent number: 6531292
    Abstract: The present invention provides isolated nucleic acid sequences which encode a family of HMG-CoA Reductase Degradation (HRD) polypeptides. More particularly, the present invention provides isolated HRD1, HRD2 and HRD3 nucleic acids and the Hrd polypeptides encoded by such nucleic acids, i.e., Hrd1, Hrd2 and Hrd3, respectively. Vectors comprising the nucleic acids are provided. In addition, the present invention provides screening assay related to cholesterol biosynthesis.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: March 11, 2003
    Assignee: The Regents of the University of California
    Inventors: Jasper D. Rine, Randolph Hampton
  • AFC1 and RCE1: isoprenylated CAAX processing enzymes
    Patent number: 6391574
    Abstract: Two genes which encode polypeptides that mediate post-prenylation processing steps in CAAX polypeptides such as Ras are provided. The two genes (AFC1 and RCE1) encode polypeptides that mediate the removal of the AAX tripeptide from the CAAX polypeptide following prenylation. The genes and encoded polypeptides provide assays for testing compounds for an effect on post-prenylation processing steps. A heat shock assay for assessing Ras activity is also provided.
    Type: Grant
    Filed: November 3, 1998
    Date of Patent: May 21, 2002
    Assignee: The Regents of the University of California
    Inventors: Jasper D. Rine, Victor L. Boyartchuk, Matthew N. Ashby
  • Genes and proteins controlling cholesterol synthesis
    Patent number: 6333172
    Abstract: The present invention provides isolated nucleic acid sequences which encode a family of HMG-CoA Reductase Degradation (HRD) polypeptides. More particularly, the present invention provides isolated HRD1, HRD2 and HRD3 nucleic acids and the Hrd polypeptides encoded by such nucleic acids, i.e., Hrd1, Hrd2 and Hrd3, respectively. Vectors comprising the nucleic acids are provided. In addition, the present invention provides screening assay related to cholesterol biosynthesis.
    Type: Grant
    Filed: January 11, 1999
    Date of Patent: December 25, 2001
    Assignee: The Regents of the University of California
    Inventors: Jasper D. Rine, Randolph Hampton
  • Genes and proteins controlling cholesterol synthesis
    Patent number: 6107462
    Abstract: The present invention provides isolated nucleic acid sequences which encode a family of HMG-CoA Reductase Degradation (HRD) polypeptides. More particularly, the present invention provides isolated HRD1, HRD2 and HRD3 nucleic acids and the Hrd polypeptides encoded by such nucleic acids, i.e., Hrd1, Hrd2 and Hrd3, respectively. Vectors comprising the nucleic acids are provided. In addition, the present invention provides screening assay related to cholesterol biosynthesis.
    Type: Grant
    Filed: August 16, 1996
    Date of Patent: August 22, 2000
    Assignee: The Regents of the University of California
    Inventors: Jasper D. Rine, Randolph Hampton