Abstract: A lipid-based coating composition for coating a medical device, wherein the coating composition includes a) lipid vesicles consisting of i. 85-95 mol % of a phospholipid (A) having a phosphatidylcholine group; ii. 5-12 mol % of a PEGylated phospholipid (B); optionally 0-3 mol % of a lipophilic compound (C) other than lipids (A) and (B); b) 0-5 wt. % of a water-soluble additive (D); and c) at least 95 wt. % of water, wherein lipid vesicles having a number average size between 50 and 140 nm (measured according to dynamic light scattering) and wherein the lipid vesicle concentration ranges between 0.025 mg/ml and 2 mg/ml, and wherein the mol % of lipids (A), (B) and (C) is calculated relative to the total molar amount of lipids (A)+(B)+(C) in the lipid-based coating composition and wherein the wt. % of water-soluble additive (D) is calculated relative to the weight of the total composition. Preferably the medical device is a contact lens, a catheter or a medical implant.

Abstract: A process for making lipid-coated substrates including the steps of a. providing a lipid solution (A) of phospholipids in a water miscible organic solvent at a phospholipid concentration between 25 and 450 mg/ml; b. provide an aqueous solution (B) having pH between 4 and 8; c. agitate the aqueous solution (B) and dispense the lipid solution (A) into the aqueous solution (B) to prepare an aqueous dispersion including lipid vesicles (C) having a number average size between 80 and 120 nm (measured according to dynamic light scattering) at a phospholipid concentration between 0.05 mg/ml and 2 mg/ml; and d. applying the aqueous dispersion (C) to a substrate and formation of a lipid-based coating; wherein aqueous dispersion (C) contains at least 95 wt. % water. Medical devices including a lipid-based coating, for example contact lenses and catheters.

Abstract: A process for the preparation of an object, supporting a lipid bilayer, for use in tissue engineering including the steps of providing an object having a surface, treating the surface of the object with a plasma containing active oxygen to provide the surface of the object with reactive groups A, to provide the surface of the object with reactive groups A, covalently attaching a sterol group to the reactive groups A and contacting the object activated with sterol groups with a lipid solution to form a lipid bilayer.

Abstract: A process for the preparation of an object, supporting a lipid bilayer, for use in tissue engineering including the steps of providing an object having a surface, treating the surface of the object with a plasma containing active oxygen to provide the surface of the object with reactive groups A, to provide the surface of the object with reactive groups A, covalently attaching a sterol group to the reactive groups A and contacting the object activated with sterol groups with a lipid solution to form a lipid bilayer.