Patents by Inventor Jaulang Hwang

Jaulang Hwang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tn vaccine composition and method for alleviating inflammation
    Patent number: 10485868
    Abstract: The present invention develops a vaccine composition against and treatment or prevention on inflammation and lung injury (particularly hyperoxia-induced lung injury) and progression of periodontitis. Tn immunization increases serum anti-Tn antibody titers, while it decreases lavaged protein and cytokines, and also decreases mean linear intercept and lung injury score. Furthermore, the improvement in lung injury is accompanied by a decrease in NF-?B activity.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: November 26, 2019
    Assignee: TAIPEI MEDICAL UNIVERSITY
    Inventors: Jaulang Hwang, Chung-Ming Chen
  • TN VACCINE COMPOSITION AND METHOD FOR ALLEVIATING INFLAMMATION
    Publication number: 20190083613
    Abstract: The present invention develops a vaccine composition against and treatment or prevention on inflammation and lung injury (particularly hyperoxia-induced lung injury) and progression of periodontitis. Tn immunization increases serum anti-Tn antibody titers, while it decreases lavaged protein and cytokines, and also decreases mean linear intercept and lung injury score. Furthermore, the improvement in lung injury is accompanied by a decrease in NF-?B activity.
    Type: Application
    Filed: September 19, 2017
    Publication date: March 21, 2019
    Inventors: Jaulang HWANG, Chung-Ming CHEN
  • CETP antigenic peptide and fusion protein and their composition and applications
    Patent number: 9944684
    Abstract: The disclosure provides an antigenic peptide targeting the extracellular, but not the intracellular, form of CETP to reduce the level of LDL (including oxLDL and other derivatives of LDL) and increase the level of HDL. Accordingly, the disclosure provides a CETP vaccine to overcome the low immunogenicity of CETP and for long-term inhibition of CETP activity to prevent or treat oxLDL or other LDL derivative-related diseases/symptoms.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: April 17, 2018
    Assignee: Taipei Medical University
    Inventor: Jaulang Hwang
  • CETP ANTIGENIC PEPTIDE AND FUSION PROTEIN AND THEIR COMPOSITION AND APPLICATIONS
    Publication number: 20160145312
    Abstract: The disclosure provides an antigenic peptide targeting the extracellular, but not the intracellular, form of CETP to reduce the level of LDL (including oxLDL and other derivatives of LDL) and increase the level of HDL. Accordingly, the disclosure provides a CETP vaccine to overcome the low immunogenicity of CETP and for long-term inhibition of CETP activity to prevent or treat oxLDL or other LDL derivative-related diseases/symptoms.
    Type: Application
    Filed: October 22, 2015
    Publication date: May 26, 2016
    Inventor: Jaulang HWANG
  • Immunogenic protein carrier containing an antigen presenting cell binding domain and a cysteine-rich domain
    Patent number: 8383767
    Abstract: A protein carrier containing an antigen presenting cell binding domain and a cysteine-rich domain. Also described herein is an immunoconjugate containing the protein carrier with an antigen conjugated to multiple cysteine residues in the cysteine-rich domain, and an immune composition containing the immunoconjugate and an adjuvant, as well as their uses in eliciting immune responses.
    Type: Grant
    Filed: June 25, 2009
    Date of Patent: February 26, 2013
    Assignee: Academia Sinica
    Inventors: Jaulang Hwang, Chun-Cheng Lin, Hsiao-Ling Chiang, Fan-Dan Jan, Chiao-En Chen, Chia-Tse Shu
  • Immunogenic Protein Carrier Containing An Antigen Presenting Cell Binding Domain and A Cysteine-Rich Domain
    Publication number: 20090324619
    Abstract: A protein carrier containing an antigen presenting cell binding domain and a cysteine-rich domain. Also described herein is an immunoconjugate containing the protein carrier with an antigen conjugated to multiple cysteine residues in the cysteine-rich domain, and an immune composition containing the immunoconjugate and an adjuvant, as well as their uses in eliciting immune responses.
    Type: Application
    Filed: June 25, 2009
    Publication date: December 31, 2009
    Applicant: Academia Sinica
    Inventors: Jaulang Hwang, Chun-Cheng Lin, Hsiao-Ling Chiang, Fan-Dan Jan, Chiao-En Chen, Chia-Tse Shu
  • Peptide repeat immunogens
    Patent number: 6838553
    Abstract: The invention relates to a polypeptide including (1) a receptor binding domain of a Pseudomonas exotoxin A, and (2) at least two copies of a peptide sequence.
    Type: Grant
    Filed: October 5, 1999
    Date of Patent: January 4, 2005
    Assignee: Academia Sinica
    Inventors: Jaulang Hwang, Chia-Tse Hsu, Chun-Jen Ting
  • Peptide repeat immunogens
    Publication number: 20030044936
    Abstract: A polypeptide containing a carrier peptide sequence and a plurality of epitope peptide sequences.
    Type: Application
    Filed: April 11, 2002
    Publication date: March 6, 2003
    Inventors: Jaulang Hwang, Chia-Tse Hsu, Chun-Jen Ting
  • Topoisomerase 1-mediated DNA delivery
    Patent number: 6387684
    Abstract: The invention relates to a polypeptide having (1) a ligand domain that specifically binds to a molecule on an external surface of a cell, and (2) a DNA binding domain of a Topoisomerase I. The polypeptide optionally contains a translocation domain to facilitate DNA delivery into a cell.
    Type: Grant
    Filed: September 13, 1999
    Date of Patent: May 14, 2002
    Assignee: Academia Sinica
    Inventors: Jaulang Hwang, Cho-Fat Hui, Tzong-Yueh Chen