Patents by Inventor Jaume Veciana
Jaume Veciana has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240115502Abstract: The present invention refers to a liposome comprising: a) a phospholipid; b) cholesterol (chol); c) a conjugate comprising a cholesterol moiety, a polyethylene glycol (PEG) moiety and a peptide moiety comprising a RGD sequence, wherein the PEG moiety is covalently attached to the cholesterol moiety by one end via a bond of the type alkyl ether and is covalently attached to the peptide moiety comprising the RGD sequence by the other end: d) a non-lipid cationic surfactant present in a percentage of less than 30% mol in respect to the total mol of the components of the liposome a), b), c) and d); and e) alpha-galactosidase (GLA) enzyme present in a ratio of micrograms of GLA in respect to the total milligrams of the components of the liposome a), b), c) and d) of between and including 2 to 35. It also refers to a pharmaceutical composition that comprises it and to the liposome or the pharmaceutical composition for use as a medicament, in particular for use in the treatment of Fabry disease.Type: ApplicationFiled: January 26, 2022Publication date: April 11, 2024Inventors: Leonor VENTOSA RULL, Jaume VECIANA MIRÓ, Miriam ROYO EXPOSITO, Judit TOMSEN MELERO, Ibane ABASOLO OLAORTUA, Simón SCHWARTZ NAVARRO, Jose Luis CORCHERO NIETO, Daniel PULIDO MARTINEZ, Edgar CRISTÓBAL LECINA, Elisabet GONZÁLEZ MIRA, Santiago SALA VERGÉS, Alba CÓRDOBA INSENSÉ, Josep MERLO MAS, Andreu SOLDEVILA FÁBREGA, Albert FONT INGLÉS
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Publication number: 20230201114Abstract: The present invention discloses a hydrogel comprising a functionalized PEG multi-arm star polymer covalently combined with maleimide-functionalized low molecular weight heparin, further comprising at least one positively charged immune molecule, a method for producing this hydrogel and its use in T cell culture for immunotherapies. Furthermore, the invention relates to a bioink and its use in 3D-(bio)-printing.Type: ApplicationFiled: May 21, 2021Publication date: June 29, 2023Inventors: Judit GUASCH CAMELL, Imma RATERA BASTARDAS, Jaume VECIANA MIRÓ, Eduardo PÉREZ DEL RÍO, Marc MARTINEZ MIGUEL, Xavier RODRÍGUEZ RODRÍGEUEZ, Roberto Fabião SANTOS ABREU, Miguel Ángel MATEOS TIMONEDA, Elisabeth ENGEL LÓPEZ
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Patent number: 11510965Abstract: The invention relates to vesicles comprising Epidermal Growth Factor (EGF), a cationic surfactant and cholesterol or derivatives thereof. The invention also discloses a procedure for their preparation, based on compressed fluid technology (CFs). The vesicles of the invention are useful in the manufacture of drugs and cosmetics and in tissue engineering.Type: GrantFiled: July 31, 2017Date of Patent: November 29, 2022Assignee: Centro de Ingeniería Genética y BiotecnologíaInventors: Héctor Jesús Santana Milian, Leonor Ventosa Rull, Eduardo Martínez Díaz, Jorge Amador Berlanga Acosta, Ingrid Cabrera Puig, Jaume Veciana Miró
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Publication number: 20220249376Abstract: The present invention refers to a nanovesicle comprising a sterol and a non-lipid cationic surfactant, for example myristalkonium chloride, wherein the sterol comprises DC-cholesterol. It also refers to a pharmaceutical composition that comprises it and its uses as a delivery system and as a bioimaging and theranostic tool. Furthermore, it also refers to the nanovesicle or the pharmaceutical composition for use as a medicament, in particular for use in the treatment of cancer.Type: ApplicationFiled: May 12, 2020Publication date: August 11, 2022Inventors: Miguel Francisco SEGURA GINARD, Soledad GALLEGO MELCON, Josep SÁNCHEZ DE TOLEDO CODINA, Aroa SORIANO FERNÁNDEZ, Nora VENTOSA RULL, Jaume VECIANA MIRÓ, Ariadna BOLOIX AMENÓS, Nathaly Verónica SEGOVIA RAMOS
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Publication number: 20180015145Abstract: The invention relates to vesicles comprising Epidermal Growth Factor (EGF), a cationic surfactant and cholesterol or derivatives thereof. The invention also discloses a procedure for their preparation, based on compressed fluid technology (CFs). The vesicles of the invention are useful in the manufacture of drugs and cosmetics and in tissue engineering.Type: ApplicationFiled: July 31, 2017Publication date: January 18, 2018Inventors: Héctor Jesús Santana Milián, Leonor Ventosa Rull, Eduardo Martínez Díaz, Jorge Amador Berlanga Acosta, Ingrid Cabrera Puig, Jaume Veciana Miró
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Patent number: 9744247Abstract: The invention relates to conjugates in which a sterol is functionalized by an ether bond with a water-soluble polymer to which a guiding ligand is bound. These conjugates improve the physico-chemical and delivery properties of their carrying vesicles, making these more stable, homogeneous and effective. A method for their preparation, a pharmaceutical composition containing said liposomes, and their therapeutic use are described as well.Type: GrantFiled: June 28, 2013Date of Patent: August 29, 2017Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC), FUNDACIÓ PARC CIENTÍFIC DE BARCELONA, CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED, FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA), UNIVERSITAT DE BARCELONA, FUNDACIÓ HOSPITAL UNIVERSITARI VALL D'HEBRON—INSTITUT DE RECERCA, UNIVERSITAT AUTÒNOMA DE BARCELONAInventors: Leonor Ventosa Rull, Jaume Veciana Miró, Ingrid Cabrera Puig, Elisa Elizondo Saez De Vicuña, Marta Melgarejo Diaz, Miriam Royo Expósito, Fernando Albericio Palomera, Daniel Pulido Martinez, Santiago Sala Vergés, Jose Luis Corchero Nieto, Simón Schwartz Navarro, Ibane Abasolo Olaortua, Antonio Pedro Villaverde Corrales
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Patent number: 9717776Abstract: The invention relates to vesicles comprising Epidermal Growth Factor (EGF), a cationic surfactant and cholesterol or derivatives thereof. The invention also discloses a procedure for their preparation, based on compressed fluid technology (CFs). The vesicles of the invention are useful in the manufacture of drugs and cosmetics and in tissue engineering.Type: GrantFiled: August 2, 2013Date of Patent: August 1, 2017Assignees: CENTRO DE INGENIERÍA GENÉTICA Y BIOTECNOLOGÍA, CONSEJO SUPERIOR DE INVESTIGACIONES CENTÍFICASInventors: Héctor Jesús Santana Milián, Leonor Ventosa Rull, Eduardo Martínez Díaz, Jorge Amador Berlanga Acosta, Ingrid Cabrera Puig, Jaume Veciana Miró
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Publication number: 20150190530Abstract: The invention relates to conjugates in which a sterol is functionalized by an ether bond with a water-soluble polymer to which a guiding ligand is bound. These conjugates improve the physico-chemical and delivery properties of their carrying vesicles, making these more stable, homogeneous and effective. A method for their preparation, a pharmaceutical composition containing said liposomes, and their therapeutic use are described as well.Type: ApplicationFiled: June 28, 2013Publication date: July 9, 2015Applicants: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC), FUNDACIÓ PRIVADA PARC CIENTÍFIC DE BARCELONA, CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED EN BIONG- ENIERÍA, BIOMATERIALES Y NANOMEDICINA (CIBER-BBN), FUNDACIÓ PRIVADA INSTITUT DE RECERCA BIOMÈDICA, UNIVERSITAT DE BARCELONA, FUNDACIÓ HOSPITAL UNIVERSITARI VALL D'HEBRON- INSTITUT DE RECERCA, UNIVERSITAT AUTÒNOMA DE BARCELONAInventors: Leonor Ventosa Rull, Jaume Veciana Miró, Ingrid Cabrera Puig, Elisa Elizondo Saez De Vicuña, Marta Melgarejo Diaz, Miriam Royo Expósito, Fernando Albericio Palomera, Daniel Pulido Martinez, Santiago Sala Vergés, Jose Luis Corchero Nieto, Simón Schwartz Navarro, Ibane Abasolo Olaortua, Antonio Pedro Villaverde Corrales
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Publication number: 20150182590Abstract: The invention relates to vesicles comprising Epidermal Growth Factor (EGF), a cationic surfactant and cholesterol or derivatives thereof. The invention also discloses a procedure for their preparation, based on compressed fluid technology (CFs). The vesicles of the invention are useful in the manufacture of drugs and cosmetics and in tissue engineering.Type: ApplicationFiled: August 2, 2013Publication date: July 2, 2015Inventors: Héctor Jesús Santana Milián, Leonor Ventosa Rull, Eduardo Martínez Díaz, Jorge Amador Berlanga Acosta, Ingrid Cabrera Puig, Jaume Veciana Miró
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Patent number: 8613953Abstract: The invention provides a novel method for obtaining solid micro- or nanoparticles with a homogeneous structure. A method is provided for obtaining solid micro- or nanoparticles with a homogeneous structure having a particle size of less than 10 ?m where the processed solid compound has the natural, crystalline, amorphous, polymorphic and other features associated with the starting compound. In accordance with the invention a method which also makes it possible to obtain solid micro- or nanoparticles with a substantially spheroidal morphology is provided.Type: GrantFiled: November 6, 2009Date of Patent: December 24, 2013Assignees: Consejo Superior de Investigaciones Científicas, Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales Y NanomedicinaInventors: Nora Ventosa Rull, Jaume Veciana Miró, Mary Cano Sarabia, Santiago Sala Vergés
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Publication number: 20120004308Abstract: The invention provides a novel method for obtaining solid micro- or nanoparticles with a homogeneous structure. A method is provided for obtaining solid micro- or nanoparticles with a homogeneous structure having a particle size of less than 10 ?m where the processed solid compound has the natural, crystalline, amorphous, polymorphic and other features associated with the starting compound. In accordance with the invention a method which also makes it possible to obtain solid micro- or nanoparticles with a substantially spheroidal morphology is provided.Type: ApplicationFiled: November 6, 2009Publication date: January 5, 2012Applicants: CENTRO DE INVESTIGACION BIOMEDICA EN RED EN BIOINGENIERIA, BIOMATERIALES Y NANOM, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICASInventors: Nora Ventosa Rul, Jaume Veciana Miró, Mary Cano Sarabia, Santiago Sala Vergés
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Publication number: 20110268773Abstract: The present invention relates to an isolated inclusion body comprising a polypeptide, characterised in that such inclusion body is in particulate form. The present invention also refers to a bacterial cell comprising said inclusion body. The present invention additionally refers to a composition comprising said inclusion body and a eukaryotic cell. The present invention moreover refers to a composition comprising said inclusion body and animal or plant tissue. The present invention furthermore refers to the uses of said inclusion body as medicaments and cell-proliferation stimulators and tissue regenerators.Type: ApplicationFiled: December 22, 2009Publication date: November 3, 2011Applicants: UNIVERSITAT AUTÒNOMA DE BARCELONA, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICASInventors: Jaume Veciana Miro, Inmaculada Ratera Bastardas, César Díez Gil, Antonio Pedro Villaverde Corrales, Esther Vázquez Gómez, Elena García Fruitós
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Publication number: 20110184271Abstract: The invention is characterized in that it comprises a truncated contact lens (1), whose truncation plane is parallel to the base of said contact lens, and a polymeric nanocomposite material (2) centrally disposed and attached to the perimeter of the truncated area, said material being sensitive to pressure changes, biocompatible and transparent, and including contact electrodes (3), and in that it also comprises means for transmitting IOP measurement data to an external system. The invention also relates to a method for measuring IOP using said lens comprising: i) placing said sensor contact lens in the eye to determine its intraocular pressure; ii) providing a direct current value between external electrodes; iii) ?V measurement between internal electrodes; and iv) identifying whether the value obtained is outside the linear response, expressed in changes of resistivity, of the polymeric nanocomposite material. The invention also relates to a telemetry system comprising said lens.Type: ApplicationFiled: June 5, 2009Publication date: July 28, 2011Inventors: Jaume Veciana, Concepió Rovira, Marta Mas-Torrent, Rosa Villa Sanz, Jordi Aguiló Llobet, José Carlos Pastor, Fernando Ussa, Elena Laukhina, Vladimer Laukhin, Raúl Martin Herranz, Antón Guimera
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Patent number: 7754777Abstract: The invention relates to a method for obtaining micro- and nanodisperse systems. In particular, it relates to a method that allows said systems, such as liposomes, emulsions and suspensions, to be obtained with a size of less than 50 ?m, and preferably less than 1 ?m, and with improved stability properties over time, which includes the stages of a) Dissolving or suspending a compound C in a fluid A, to obtain a mixture AC, in the form of a solution or dispersion; b) Thermostatising said mixture AC to a temperature of between ?50° C. and 200° C.; c) Adding a fluid B to mixture AC until a pressure P is obtained; and it is characterised in that in said stage (c) formation of the solution AB occurs and because it includes, d) Reducing the pressure of solution AB to a pressure lower than or equal to 100 bars, and then e) Adding a fluid E, in which fluid A is miscible and in which compound C is partially or totally insoluble at atmospheric pressure, with said fluid E acting as a crystallisation interruption agent.Type: GrantFiled: January 3, 2006Date of Patent: July 13, 2010Assignee: Sociedad Espanola De Carburos Metalicos, S.A.Inventors: Nora Ventosa, Jaume Veciana, Santiago Sala, Mary Cano
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Publication number: 20100129258Abstract: Disclosed herein are embodiment relating to a methods of obtaining a functionalized porous or fibrous solid substrate with the chemical and/or physical properties of a nano-structured molecular or polymer chemical compound that contains it. In accordance with some example embodiments, the properties of the starting substrate may be modified to obtain a new functionalized substrate. The new substrate may have various applications, such as, for example, an optical- and/or fluorescent-type chemical sensor, as a chemical sequestrator, or as a modifier of the properties of a surface, making it, for example, superhydrophobic.Type: ApplicationFiled: December 5, 2007Publication date: May 27, 2010Inventors: César Diez Gil, Imma Ratera Bastardas, Jaume Veciana Miró, Rosario Martinez, Faboiola Zapata, Antonio Caballero, Alberto Tárraga, Pedro Molina
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Publication number: 20100028209Abstract: The invention is characterised in that it has a layer of organic material sensitive to changes in pressure, voltage, deformation, gases and/or temperature; wherein said organic layer consists of at least one conductive salt or complex including a molecule A and a dopant D, said molecule A being an electron donor or acceptor organic molecule or macromolecule capable of forming a conductive salt or complex, which without doping is not conductive, and with the presence of dopant D becomes a compound that is donor or acceptor of electrons and capable of forming conductive salt or complex with the molecule or macromolecule A; and a base substrate, in close contact with said layer of organic material. The sensor device is useful in molecular electronics or plastic electronics, in particular, in the field of organic sensors.Type: ApplicationFiled: November 13, 2007Publication date: February 4, 2010Inventors: Elena Laukhina, Marta Mas Torrent, Concepcio Rovira Angulo, Jaume Veciana Miro, Vladimir Laukhin
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Publication number: 20090302279Abstract: The invention relates to a chemical method that enables the direct design of a pattern on an organic substrate having semiconductor-, superconductor- or metallic-type conducting properties. The invention also relates to the organic material thus obtained, which is intended for use in electronic devices, such as resistors, capacitors, transistors, sensors or electrodes among others, or for use in other applications requiring a determined pattern of conductor or semiconductor zones and less-conducting, non-conducting or insulating zones.Type: ApplicationFiled: July 28, 2006Publication date: December 10, 2009Applicant: CONSEJO SUPRRIOR DE INVESGIGACIANES CIENTIFICASInventors: Jaume Veciana Miro, Maria Concepcion Rovira Angulo, Elena E. Laukhina, Marta Mas Torrent, Vladimir Laukhin, Dmitri V. Petrov, Caitriona M. Creely
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Patent number: 7291295Abstract: A method for precipitation of finely divided solid particles comprising a) Dissolving a compound C in a fluid A to provide a solution A; b) Thermostatization of said solution A to a temperature ranging between ?50°0 C. and 200° C.; c) Adding a fluid B to said solution A until a pressure P is obtained, characterized in that said fluid B at a pressure P is miscible with said solution A and acts as a co-solvent to form a solution AB; d) Adding an inert gas to solution AB so as to maintain the pressure P; and e) Reducing the pressure of said solution AB so as to produce the precipitation of said compound C, and wherein the method permits particles of average size less than 20 ?m, with a narrow distribution ranging between 1 and 100 ?m, from a solution, and not a mix, that contains the compound C precipitated.Type: GrantFiled: August 23, 2001Date of Patent: November 6, 2007Assignee: Sociedad Espanola de Carburos Metalicos, S.A.Inventors: Nora Ventosa Rull, Jaume Veciana Miro, Concepción Rovira Angulo, Santiago Sala Verges
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Publication number: 20030098517Abstract: Comprises a) dissolving a compound C in a fluid A to provide a solution A; b) Thermostatization of said solution A to a temperature ranging between −50° C. and 200° C.; c) Adding a fluid B to said solution A until a pressure P is obtained, and is characterized in that said fluid B at a pressure P is miscible with said solution A, and acts as a co-solvent to form a solution AB; and d) Reduce the pressure of said solution AB so as to produce the precipitation of said compound C.Type: ApplicationFiled: October 9, 2002Publication date: May 29, 2003Inventors: Nora Ventosa Rull, Jaume Veciana Miro, Concepcion Rovira Angulo, Santiago Sala Verges