Patents by Inventor Javier Apfeld

Javier Apfeld has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Eukaryotic genes involved in adult lifespan regulation
    Patent number: 7794957
    Abstract: The present invention relates to regulation of adult lifespan in eukaryotes. More particularly, the present invention is directed to methods of assaying for activators of the heat shock factor 1 (HSF-1) protein, which increases lifespan when overexpressed in an organism.
    Type: Grant
    Filed: November 18, 2005
    Date of Patent: September 14, 2010
    Assignee: Regents of the University of California
    Inventors: Cynthia Kenyon, Javier Apfeld, Andrew Dillin, Delia Garigan, Ao-Lin A. Hsu, Josh Lehrer-Graiwer, Coleen Murphy
  • Eukaryotic genes involved in adult lifespan regulation
    Publication number: 20060162002
    Abstract: The present invention relates to regulation of adult lifespan in eukaryotes. More particularly, the present invention is directed to methods of assaying for genes, gene products, and genes in pathways controlled by such genes and gene products, using RNAi and microarray analysis, that regulate lifespan (e.g., extend or truncate adult lifespan) in eukaryotes such as invertebrates (e.g., C. elegans), plants, and mammals, e.g., humans. For example, the present invention is directed to genes encoding components of the mitochondrial respiratory chain and genes encoding glycolysis enzymes, which are involved in lifespan regulation, and genes and gene products in pathways controlled by such genes.
    Type: Application
    Filed: November 18, 2005
    Publication date: July 20, 2006
    Applicant: The Regents of the University of California
    Inventors: Cynthia Kenyon, Javier Apfeld, Andrew Dillin, Delia Garigan, Ao-Lin Hsu, Josh Lehrer-Graiwer, Coleen Murphy
  • AMPK pathway components
    Publication number: 20060147947
    Abstract: Control of AMPK activity enables interventions that modulate lifespan regulation. Agents which alter lifespan regulation of a cell or organism are identified by screening for compounds that regulate AMPK activity or AMPK pathway activity. The agents so-identified and compounds known to alter AMPK pathway activity can be administered to a subject, e.g., to alter lifespan regulation in the subject or to affect a longevity-associated disorder, or a risk, symptom, predisposition thereof.
    Type: Application
    Filed: June 3, 2005
    Publication date: July 6, 2006
    Inventors: Javier Apfeld, Greg O'Connor
  • Eukaryotic genes involved in adult lifespan regulation
    Publication number: 20030190312
    Abstract: The present invention relates to regulation of adult lifespan in eukaryotes. More particularly, the present invention is directed to methods of assaying for genes, gene products, and genes in pathways controlled by such genes and gene products, using RNAi and microarray analysis, that regulate lifespan (e.g., extend or truncate adult lifespan) in eukaryotes such as invertebrates (e.g., C. elegans), plants, and mammals, e.g., humans. For example, the present invention is directed to genes encoding components of the mitochondrial respiratory chain and genes encoding glycolysis enzymes, which are involved in lifespan regulation, and genes and gene products in pathways controlled by such genes.
    Type: Application
    Filed: June 24, 2002
    Publication date: October 9, 2003
    Applicant: The Regents of the University of California
    Inventors: Cynthia Kenyon, Javier Apfeld, Andrew Dillin, Delia Garigan, Ao-Lin A. Hsu, Josh Lehrer-Graiwer, Coleen Murphy