Patents by Inventor Javier Campos Gómez

Javier Campos Gómez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vibrio cholerae with improved biological safety features in freeze dried form
    Patent number: 7592171
    Abstract: The present invention discloses new live attenuated strains for oral immunization against cholera that are provided in freeze dried formulations for long term storage and administration to humans. These strains combine the two most important properties of live attenuated cholera vaccine candidates. One such property is being well tolerated by people ingesting them. This was achieved by virtue of mutations already described in the art. The second property is having enhanced environmental safety due to the absence of VGJ? DNA in their genomes and also due to null mutations in the mshA gene or other spontaneous mutations conducive to the lack of MSHA type IV fimbria on the bacterial surface. This was done envisioning that VGJ? is a filamentous phage able to recombine with CTX? and disseminate the cholera toxin genes. This VGJ? phage as well as the VGJ?-CTX? recombinants uses the MSHA fibers as receptor.
    Type: Grant
    Filed: February 19, 2004
    Date of Patent: September 22, 2009
    Assignee: Centro Nacional de Investigaciones Cientificas (CNIC)
    Inventors: Javier Campos Gómez, Tomas Marcelino Moreira Hernandez, Boris Luis Rodriguez Gonzalez, Karen Marrero Dominguez, Eriel Martinez Gutierrez, Talena Yamile Ledon Perez, Yussuan Silva Larrañaga, Edith Suzarte Portal, Herminia de la Caridad Delgado Rodriguez, Caridad Urra Villavicencio, Rafael Alfredo Fando Calzada
  • Attenuated strains of vibrio cholerae with improved biological safety features in freeze dried form for oral vaccination
    Publication number: 20070071775
    Abstract: The present invention discloses new live attenuated strains for oral immunization against cholera that are provided in freeze dried formulations for long term storage and administration to humans. These strains combine the two most important properties of live attenuated cholera vaccine candidates. One such property is being well tolerated by people ingesting them. This was achieved by virtue of mutations already described in the art. The second property is having enhanced environmental safety due to the absence of VGJ? DNA in their genomes and also due to null mutations in the mshA gene or other spontaneous mutations conducive to the lack of MSHA type IV fimbria on the bacterial surface. This was done envisioning that VGJ? is a filamentous phage able to recombine with CTX? and disseminate the cholera toxin genes. This VGJ? phage as well as the VGJ?-CTX? recombinants uses the MSHA fibers as receptor.
    Type: Application
    Filed: February 19, 2004
    Publication date: March 29, 2007
    Inventors: Javier Campos Gomez, Tomas Marcelino Moreira Hermandez, Boris Rodriguez Gonzalez, Karen Marrero Dominguez, Eriel Martinez Gutierrez, Talena Ledon Perez, Yussuan Silva Larranaga, Edith Suzarte Portal, Herminia Delgado Rodriguez, Caridad Urra Villavicencio, Rafael Fando Calzada
  • Vibrio Cholerae vaccine candidates and method of their constructing
    Patent number: 6723323
    Abstract: Vibrio cholerae vaccine strains which have a disrupted hap gene and which are tagged with celA coding functions from Clostridium thermocellum are described. A contained, genetically defined thyA mutant of Vibrio cholerae and the general methodology of making along with the sequence of thyA gene are also described.
    Type: Grant
    Filed: December 4, 2000
    Date of Patent: April 20, 2004
    Assignee: Centro Nacional de Investigaciones Cientificas
    Inventors: Javier Campos Gómez, Rafael Alfredo Fando Calzada, Boris Luís Rodríguez Gónzalez, Edgar Valle Díaz, Talena Yamilé Ledón Pérez, Anisia Juana Silva, Jorge Antonio Benitez Robles