Patents by Inventor Javier Gordon Ogembo

Javier Gordon Ogembo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11401323
    Abstract: Disclosed herein are antibodies or immunogenic fragments thereof that specifically bind to Epstein-Barr virus (EBV) glycoprotein 350 (gp350) or 220 or one or more epitopes of EBV gp350 and neutralize EBV infection. Also disclosed are immunogenic peptides comprising one or more gp350 epitopes, EBV antibody-small molecule conjugates and pharmaceutical compositions comprising the antibody or an immunogenic fragment thereof, one or more epitopes of EBV gp350, one or more immunogenic peptides, or the EBV antibody-small molecule conjugate. The antibodies, epitopes, immunogenic peptides, conjugates, and pharmaceutical compositions can be used to treat or prevent EBV infections and EBV-associated conditions and diseases.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: August 2, 2022
    Assignees: CITY OF HOPE, CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Javier Gordon Ogembo, Lorraine Zvichapera Mutsvunguma, Alison Evelynn Ondrus
  • Publication number: 20220143174
    Abstract: Disclosed are vaccine compositions comprising a single KSHV-LP comprising two or more KSHV glycoproteins and/rl or one or more T cell antigens and methods of preventing or treating KSHV infections using the vaccine compositions. Also disclosed is an expression system or a single expression vector for co-expressing two or more KSHV glycoproteins simultaneously to generate a vaccine comprising a single virus-like particle. The expression system may include a single plasmid inserted with two or more nucleic acid sequences that encode two or more KSHV glycoproteins linked by one or more linking sequences such that the KSHV glycoproteins are co-expressed simultaneously.
    Type: Application
    Filed: February 21, 2020
    Publication date: May 12, 2022
    Applicant: CITY OF HOPE
    Inventors: Javier Gordon OGEMBO, Lorraine Zvichapera MUTSVUNGUMA, David H. MULAMA, Murali MUNIRAJU
  • Publication number: 20210115113
    Abstract: Disclosed herein are antibodies or immunogenic fragments thereof that specifically bind to Epstein-Barr virus (EBV) glycoprotein 350 (gp350) or 220 or one or more immunogenic peptides. Also disclosed are immunogenic peptides comprising fragments of gp350 amino acid sequence, EBV antibody-small molecule conjugates and pharmaceutical compositions comprising the antibody or an immunogenic fragment thereof, one or more immunogenic peptides, or the EBV antibody-small molecule conjugate. The antibodies, immunogenic peptides, conjugates, and pharmaceutical compositions can be used to treat or prevent EBV infections and EBV-associated conditions and diseases.
    Type: Application
    Filed: July 27, 2020
    Publication date: April 22, 2021
    Applicant: CITY OF HOPE
    Inventors: Javier Gordon OGEMBO, Lorraine Zvichapera MUTSVUNGUMA
  • Patent number: 10960072
    Abstract: The present invention relates to prophylactic and/or therapeutic vaccines that contain Newcastle disease Virus (NDV) virus-like particles (VLPs) comprising one or more Epstein-Barr Virus (EBV) antigens. In one embodiment, the invention provides a recombinant virus-like particle (VLP) comprising, in operable combination, a) Newcastle disease virus (NDV) matrix (M) protein, and b) one or more Epstein-Barr Virus (BBV) antigens. The invention's prophylactic and/or therapeutic vaccines are useful for preventing and/or treating infection with EBV and/or disease associated Epstein-Barr Virus, such as cancer.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: March 30, 2021
    Assignee: The University of Massachusetts
    Inventors: Javier Gordon Ogembo, Trudy Morrison
  • Publication number: 20200276295
    Abstract: Disclosed are vaccine compositions comprising a VLP comprising two or more EBV envelope glycoproteins and one or more T cell antigens and methods of preventing or treating EBV infections using the vaccine compositions. Also disclosed is an expression system or a single expression vector for co-expressing two or more EBV envelope glycoproteins simultaneously to generate a VLP vaccine. The expression system may include a single vector inserted with two or more nucleic acid sequences that encode two or more EBV envelope glycoproteins linked by one or more linking sequences such that the EBV envelope glycoproteins are co-expressed simultaneously.
    Type: Application
    Filed: September 16, 2018
    Publication date: September 3, 2020
    Applicant: CITY OF HOPE
    Inventors: Javier Gordon OGEMBO, Lorraine Zvichapera MUTSVUNGUMA
  • Publication number: 20200055924
    Abstract: Disclosed herein are antibodies or immunogenic fragments thereof that specifically bind to Epstein-Barr virus (EBV) glycoprotein 350 (gp350) or 220 or one or more epitopes of EBV gp350 and neutralize EBV infection. Also disclosed are immunogenic peptides comprising one or more gp350 epitopes, EBV antibody-small molecule conjugates and pharmaceutical compositions comprising the antibody or an immunogenic fragment thereof, one or more epitopes of EBV gp350, one or more immunogenic peptides, or the EBV antibody-small molecule conjugate. The antibodies, epitopes, immunogenic peptides, conjugates, and pharmaceutical compositions can be used to treat or prevent EBV infections and EBV-associated conditions and diseases.
    Type: Application
    Filed: April 27, 2018
    Publication date: February 20, 2020
    Inventors: Javier Gordon OGEMBO, Lorraine Zvichapera MUTSVUNGUMA, Alison Evelynn ONDRUS
  • Publication number: 20200038505
    Abstract: The present invention relates to prophylactic and/or therapeutic vaccines that contain Newcastle disease Virus (NDV) virus-like particles (VLPs) comprising one or more Epstein-Barr Virus (EBV) antigens. In one embodiment, the invention provides a recombinant virus-like particle (VLP) comprising, in operable combination, a) Newcastle disease virus (NDV) matrix (M) protein, and b) one or more Epstein-Barr Virus (BBV) antigens. The invention's prophylactic and/or therapeutic vaccines are useful for preventing and/or treating infection with EBV and/or disease associated Epstein-Barr Virus, such as cancer.
    Type: Application
    Filed: April 19, 2019
    Publication date: February 6, 2020
    Inventors: Javier Gordon Ogembo, Trudy Morrison
  • Patent number: 10314906
    Abstract: The present inaveation relates to prophylactic and/or therapeutic vaccines thatpoatairj Newcastle disease Virus (NDV) virus-like particles (VLPs) comprising one or more Epstein-Barr Virus (EBV) antigens, in one embodiment, the invention provides a recombinant virus-like particle (V'UP) comprising, i is operable combination, a) Newcastle disease virus? iNDVj matrix (M) protein, and b) one or more Epstein-Barr Virus (BBV) antigens. The im'eniion's prophylactic and/or therapeutic vacclrses are useful for preventing asc/or treatmg, infection with EBY aixi/or disease associated Epstein-Barr Virus, such as cancer.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: June 11, 2019
    Assignee: University of Massachusetts
    Inventors: Javier Gordon Ogembo, Trudy Morrison
  • Publication number: 20180078634
    Abstract: The present invention relates to prophylactic and/or therapeutic vaccines that contain Newcastle disease virus (NDV) virus-like particles (VLPs) comprising one or more Epstein-Barr Virus (EBV) antigens. In one embodiment, the invention provides a recombinant virus-like particle (VLP) comprising, in operable combination, a) Newcastle disease virus (NDV) matrix (M) protein, and b) one or more Epstein-Barr Virus (EBV) antigens. The invention's prophylactic and/or therapeutic vaccines are useful for preventing and/or treating infection with EBV and/or disease associated Epstein-Barr Virus, such as cancer.
    Type: Application
    Filed: March 16, 2016
    Publication date: March 22, 2018
    Applicant: THE UNIVERSITY OF MASSACHUSETTS
    Inventors: Javier Gordon Ogembo, Trudy Morrison