Patents by Inventor Javier H. Flores

Javier H. Flores has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multiwell assay apparatus and method for determining biological activity of compounds
    Patent number: 8852881
    Abstract: A device for characterizing the biological properties of cells can include a plurality of dual-compartment assay chambers wherein the compartments of each chamber are separated by a cell layer across which ions can flow. The biological properties of the cell layer in the presence or absence of experimental compounds can be determined by measuring an electrical gradient across the layer. A individual dual-compartment chamber of this type may be referred to as an “Ussing chamber.
    Type: Grant
    Filed: November 29, 2006
    Date of Patent: October 7, 2014
    Assignee: Vertex Pharmaceuticals, Inc.
    Inventors: Paul A. Negulescu, Alec T. Harootunian, Philip E. Salzmann, Javier H. Flores, James E. Sinclair, Minh Vuong, Ashvani K. Singh, Fred F. VanGoor
  • Method for sensing levels of conductive liquids
    Patent number: 7490513
    Abstract: A liquid level sensor comprises a plurality of electrodes arranged in a defined relationship with respect to a container filling trajectory, a signal generator coupled to one or more of the plurality of electrodes, a signal receiver coupled to one or more of the plurality of electrodes, and a sensing circuit coupled to at least one of the signal generator and signal receiver. The sensing circuit is configured to produce an output indicative of electrical resistance between at least one pair of the plurality of electrodes. The sensing circuit may be associated with the signal receiver and/or with the signal generator.
    Type: Grant
    Filed: May 10, 2007
    Date of Patent: February 17, 2009
    Assignee: Vertex Pharmaceuticals, Inc.
    Inventors: Philip E. Salzmann, Alec T. Harootunian, Michael P. Emery, Javier H. Flores, Todd N. Bennett, Minh Vuong
  • Sensor for levels of conductive liquids
    Patent number: 7219545
    Abstract: A liquid level sensor comprises a plurality of electrodes arranged in a defined relationship with respect to a container filling trajectory, a signal generator coupled to one or more of the plurality of electrodes, a signal receiver coupled to one or more of the plurality of electrodes, and a sensing circuit coupled to at least one of the signal generator and signal receiver. The sensing circuit is configured to produce an output indicative of electrical resistance between at least one pair of the plurality of electrodes. The sensing circuit may be associated with the signal receiver and/or with the signal generator.
    Type: Grant
    Filed: July 28, 2004
    Date of Patent: May 22, 2007
    Assignee: Vertex Pharmaceuticals, Inc.
    Inventors: Philip E. Salzmann, Alec T. Harootunian, Michael P. Emery, Javier H. Flores, Todd N. Bennett, Minh Vuong
  • Multiwell plate assembly for use in high throughput assays
    Patent number: 7169609
    Abstract: A device for characterizing the biological properties of cells can include a plurality of dual-compartment assay chambers wherein the compartments of each chamber are separated by a cell layer across which ions can flow. The biological properties of the cell layer in the presence or absence of experimental compounds can be determined by measuring an electrical gradient across the layer. A individual dual-compartment chamber of this type may be referred to as an “Ussing chamber.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: January 30, 2007
    Assignee: Vertex Pharmaceutcals, Inc.
    Inventors: Paul A. Negulescu, Alec T. Harootunian, Philip E. Salzmann, Javier H. Flores, James E. Sinclair, Minh Vuong, Ashvani K. Singh, Fred F. VanGoor