Abstract: A color printing system manages ICC profiles by controlling ink use without performing the ICC profile creation operations. To obtain an ink limit for an ICC profile, a table associated with the ICC profile is parsed to determine the ink limit. The ink limit is decreased or increased. For an ink limit decrease, a color over the decreased ink limit is adjusted to meet the new ink limit. The ICC profile is updated accordingly. For an ink limit increase, the combination of primary colors are boosted by a percentage amount. Checks are made with regard to the volume-based ink limit and an quality check operation to accepted the boosted amount. The ICC profile is updated accordingly.

Abstract: Variable data printing operations use static and variable content to create many different documents. An estimation system for printing operations implements accelerated consumable use estimation for variable data printing operations by tagging reused objects having static content. The static content is rendered within the estimation system once and then stored for use in later estimation operations, as needed. Variable content is rendered for each record. Using this process, the estimation system does not need to render reused content repeatedly in providing consumable use estimates.

Abstract: A peer-to-peer network of printing devices is configured to share printing device information, such as job queue status, configuration information, and resource information for automated load balancing, capability matching, failover, and print splitting operations. A digital front end (DFE) of a printing device establishes connections with the DFEs of other printing devices to manage output within the peer-to-peer network in an automated manner. When a print job is received at a DFE for a printing device, it is evaluated to determine how to best manage the output for the print job.

Abstract: A peer-to-peer network of printing devices is configured to share printing device information, such as job queue status, configuration information, and resource information for automated load balancing, capability matching, failover, and print splitting operations. A digital front end (DFE) of a printing device establishes connections with the DFEs of other printing devices to manage output within the peer-to-peer network in an automated manner. When a print job is received at a DFE for a printing device, it is evaluated to determine how to best manage the output for the print job.

Abstract: An estimation system provides consumable use estimations, such as for ink or toner, in printing operations. The estimation system uses a classification-based consumable use process to estimate the consumable use. A print job is assigned a classification category according to an arbitrary job category selected for the print job and a job property defined for the print job using job settings. An estimate is provided using the classification category and the distribution of the consumable use for print jobs in the category. The estimate is adjusted by a consumable use adjustment factor that reflects the amount of ink or toner disposed of during container replacement or wasted during printing operations.

Abstract: Therapeutic compositions and an associated method for improving a Toll-like receptor (TLR)-related condition, including determining a set of peptide sequences associated with a microorganism-related modulator of a TLR, determining a first set of binding parameters for the set of peptide sequences in relation to the TLR, selecting a target subset of peptide sequences from the set of peptide sequences based on the first set of binding parameters, reengineering the target subset of peptide sequences based on mutating amino acid residues of the target subset of peptide sequences, determining a second set of binding parameters for the reengineered target subset of peptide sequences in relation to the TLR, and identifying a first peptide for use in a therapeutic composition for improving the TLR-related condition, based on the second set of binding parameters for the reengineered target subset of peptide sequences.

Abstract: A spot color adjustment system allows an operator to adjust spot colors through the use of test charts printed at a printing device. A target color swatch is determined from a first spot color. A test chart is generated based on the target color swatch that includes a plurality of rings of color swatches centered on the target color swatch. Each ring of color swatches is positioned around the target color swatch at an adjustment value. The adjustment value for each ring of color swatches corresponds to a color change from the target color swatch. The system allows for determining a number of rings of color swatches depending on a selected paper size. The outer rings of a large number of rings of color include intermediary color swatches. A midpoint color is determined from a plurality of selected color swatches. The system provides color swatches showing gray component replacement.

Abstract: A method is provided that includes receiving, at a hot folder that processes print job files according to default print instructions associated with the hot folder, a submitted file selected from (a) a submitted print job file or (b) a submitted print ticket, where the submitted print ticket includes at least one submitted print instruction. The method further includes starting a delay timer upon receiving the submitted file, waiting to process the submitted file until the delay timer has expired, and, upon expiration of the delay timer, processing the submitted file. Also described are a non-transitory computer-readable medium and a printing device.

Abstract: A color printing system manages ICC profiles by controlling ink use without performing the ICC profile creation operations. To obtain an ink limit for an ICC profile, a table associated with the ICC profile is parsed to determine the ink limit. The ink limit is decreased or increased. For an ink limit decrease, a color over the decreased ink limit is adjusted to meet the new ink limit. The ICC profile is updated accordingly. For an ink limit increase, the combination of primary colors are boosted by a percentage amount. Checks are made with regard to the volume-based ink limit and an quality check operation to accepted the boosted amount. The ICC profile is updated accordingly.

Abstract: A printing system uses different color quality values to set quality levels for color printing operations. When creating a calibration for a paper, a color quality attribute is defined that corresponds with the level of color printing quality for the calibration. The resulting calibration is stored with the color quality attribute. The calibration is used to create an ICC profile that is used in color printing operations for the paper. Print jobs may indicate the color quality attribute for the paper for color printing such that the calibration and ICC profile are selected.

Abstract: A printing system uses different color quality values to set quality levels for color printing operations. When creating a calibration for a paper, a color quality attribute is defined that corresponds with the level of color printing quality for the calibration. The resulting calibration is stored with the color quality attribute. The calibration is used to create an ICC profile that is used in color printing operations for the paper. Print jobs may indicate the color quality attribute for the paper for color printing such that the calibration and ICC profile are selected.

Abstract: A printing device includes an inspection system that uses variable intervals to inspect printed sheets for a print job. The variable interval sets the inspection points for the inspection process. Once a defect is detected on a printed sheet, the sheets in the paper path are cleared and separated into good and defective sets of sheets. The cleared sheets are sent to an output bin for further review. After addressing the defect, the last good sheet printed is determined and adjusted to resume printing operations.

Abstract: A user interface works with a conflicts engine and print driver to check and prevent conflicts between the attributes related to job settings of a print job. Constraints are defined by the printing device. These constraints put limits on what can be printed. Job settings are selected for the print job by the operator using a user interface. Attributes related to the job settings are determined. Constraints are adjusted by values for the attributes. Potential conflicts are determined using the adjusted constraints and a property of the print job.

Abstract: A spot color adjustment system allows an operator to adjust spot colors through the use of test charts printed at a printing device. A target color swatch is determined from a first spot color. A test chart is generated based on the target color swatch that includes a plurality of rings of color swatches centered on the target color swatch. Each ring of color swatches is positioned around the target color swatch at an adjustment value. The adjustment value for each ring of color swatches corresponds to a color change from the target color swatch. The system allows for determining a number of rings of color swatches depending on a selected paper size. The outer rings of a large number of rings of color include intermediary color swatches. A midpoint color is determined from a plurality of selected color swatches. The system provides color swatches showing gray component replacement.

Abstract: A spot color adjustment system allows an operator to adjust spot colors through the use of test charts printed at a printing device. A target color swatch is determined from a first spot color. A test chart is generated based on the target color swatch. The test chart includes a plurality of rings of color swatches centered on the target color swatch. Each ring of color swatches is positioned around the target color swatch at an adjustment value. The adjustment value for each ring of color swatches corresponds to a color change from the target color swatch. The number of color swatches in each ring increases as they extend away from the target color swatch. A subsequent color swatch is selected having a second spot color from one of the color swatches. A new test chart is generated based on the second spot color of the subsequent color swatch.

Abstract: Variable data printing operations use static and variable content to create many different documents. An estimation system for printing operations implements accelerated consumable use estimation for variable data printing operations by tagging reused objects having static content. The static content is rendered within the estimation system once and then stored for use in later estimation operations, as needed. Variable content is rendered for each record. Using this process, the estimation system does not need to render reused content repeatedly in providing consumable use estimates.

Abstract: An estimation system provides consumable use estimations, such as for ink or toner, in printing operations. The estimation system uses a classification-based consumable use process to estimate the consumable use. A print job is assigned a classification category according to an arbitrary job category selected for the print job and a job property defined for the print job using job settings. An estimate is provided using the classification category and the distribution of the consumable use for print jobs in the category. The estimate is adjusted by a consumable use adjustment factor that reflects the amount of ink or toner disposed of during container replacement or wasted during printing operations. Estimation system also uses a size-agnostic consumable use estimation process based on the average consumable use for a specified imageable unit area.

Abstract: An estimation system provides consumable use estimations, such as for ink or toner, in printing operations. The estimation system uses a classification-based consumable use process to estimate the consumable use. A print job is assigned a classification category according to an arbitrary job category selected for the print job and a job property defined for the print job using job settings. An estimate is provided using the classification category and the distribution of the consumable use for print jobs in the category. The estimate is adjusted by a consumable use adjustment factor that reflects the amount of ink or toner disposed of during container replacement or wasted during printing operations. Estimation system also uses a size-agnostic consumable use estimation process based on the average consumable use for a specified imageable unit area.

Abstract: Relative calibration is used to generate tone reproduction curves (TRCs) at multiple printing devices. A first calibration is performed for a first paper at a first printing device to generate a first TRC. A second calibration is performed for the first paper at a second printing device to generate a second TRC. A third calibration is performed for a second paper at the first printing device to generate a third TRC. A device difference dataset is determined using the first TRC and the second TRC. A paper difference dataset is determined using the first TRC and the third TRC. The device difference dataset and the paper difference dataset are used to determine a fourth TRC for the second paper at the second printing device, thereby eliminating the need for further calibration operations.

Abstract: Described herein are antibodies (e.g., single chain variable fragment (scFv) antibodies) and constructs comprising antibody moieties that bind to the extracellular domain of CD22 or a portion thereof (e.g., SEQ ID NO: 205 or a portion thereof). Also provided herein are methods of using the same or compositions thereof for the therapeutic treatment of diseases characterized by CD22 expression, in particular, B-cell lymphomas and leukemias.