Abstract: A system and method for real-time, a closed-loop, complete body hemodynamic simulation of a patient undergoing a surgical procedure is disclosed. A simplified model of blood circulation that is nevertheless comprehensive and derives input representative of the patient's entire circulatory system, is mathematically modeled by a combination of 1-D mathematical models, and lumped parameter models. The system allows a clinician to select an intended intervention that is then computationally simulated in real, or quasi-real, time. The results of the simulation are presented as a heartbeat by heartbeat simulation of clinician selected, relevant hemodynamic parameters, allowing the clinician to decide whether or not to proceed with the intervention. The system includes accurate simulation of the effects of gravity, respiration and natural compensatory mechanisms, including the baroreflex.

Abstract: A system and method for determining a patient's suitability for a proposed surgical procedure is disclosed in which a simulated, procedure specific, whole-body, hemodynamic profile of an individual patient is obtained using a whole-body hemodynamic simulation module operating on a digital processor using a patient specific, whole-body, hemodynamic calculation parameter set. This is used by a trained clinician to evaluate whether the patient is a suitable candidate to undergo the proposed surgery. The patient specific, whole-body, hemodynamic calculation parameter set is obtained by optimizing a generic, whole-body, hemodynamic calculation parameter set. Optimization is done automatically by adjusting the generic, whole-body, hemodynamic calculation parameter set based on the comparison of simulated, whole-body, profiles corresponding to measured hemodynamic profiles of the patient in a non-operation situation. The automatic adjustment is guided by a Damped Least Squares Method and related algorithms.

Abstract: A system and method for determining a patient's suitability for a proposed surgical procedure is disclosed in which a simulated, procedure specific hemodynamic profile of an individual patient is obtained using a hemodynamic simulation module operating on a digital processor using a patient specific hemodynamic calculation parameter set. This is used by a trained clinician to evaluate whether the patient is a suitable candidate to undergo the proposed surgery. The patient specific hemodynamic calculation parameter set is obtained by optimizing a generic hemodynamic calculation parameter set. Optimization is done automatically by adjusting the generic hemodynamic calculation parameter set based on the comparison of simulated profiles corresponding to measured hemodynamic profiles of the patient in a non-operation situation. The automatic adjustment is guided by a Damped Least Squares Method and related algorithms.

Abstract: A system and method for real-time, a closed-loop, complete body hemodynamic simulation of a patient undergoing a surgical procedure is disclosed. A simplified model of blood circulation that is nevertheless comprehensive and derives input representative of the patient's entire circulatory system, is mathematically modeled by a combination of 1-D mathematical models, and lumped parameter models. The system allows a clinician to select an intended intervention that is then computationally simulated in real, or quasi-real, time. The results of the simulation are presented as a heartbeat by heartbeat simulation of clinician selected, relevant hemodynamic parameters, allowing the clinician to decide whether or not to proceed with the intervention. The system includes accurate simulation of the effects of gravity, respiration and natural compensatory mechanisms, including the baroreflex.