Patents by Inventor Javier Nazario-Larrieu

Javier Nazario-Larrieu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the production of bacterial toxins
    Patent number: 7829321
    Abstract: Methods and compositions are provided for the enhanced production of bacterial toxins in large-scale cultures. Specifically, methods and compositions for reducing bacterial toxin expression inhibitors are providing including, but not limited to, addition of toxin expression inhibitor binding compounds, culture media having reduced concentrations of toxin inhibitor metabolic precursors and genetically modified toxogenic bacteria lacking enzymes required to metabolize the toxin inhibitor metabolic precursors.
    Type: Grant
    Filed: November 29, 2005
    Date of Patent: November 9, 2010
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Milan S. Blake, John A. Bogdan, Jr., Javier Nazario-Larrieu
  • Method for the production of bacterial toxins
    Patent number: 7790185
    Abstract: Methods and compositions are provided for the enhanced production of bacterial toxins in large-scale cultures. Specifically, methods and compositions for reducing bacterial toxin expression inhibitors are providing including, but not limited to, addition of toxin expression inhibitor binding compounds, culture media having reduced concentrations of toxin inhibitor metabolic precursors and genetically modified toxogenic bacteria lacking enzymes required to metabolize the toxin inhibitor metabolic precursors.
    Type: Grant
    Filed: November 1, 2005
    Date of Patent: September 7, 2010
    Assignees: Baxter International Inc., Bacter Healthcare S.A.
    Inventors: Milan S. Blake, John A. Bogdan, Jr., Javier Nazario-Larrieu
  • Method for the production of bacterial toxins
    Publication number: 20060216789
    Abstract: Methods and compositions are provided for the enhanced production of bacterial toxins in large-scale cultures. Specifically, methods and compositions for reducing bacterial toxin expression inhibitors are providing including, but not limited to, addition of toxin expression inhibitor binding compounds, culture media having reduced concentrations of toxin inhibitor metabolic precursors and genetically modified toxogenic bacteria lacking enzymes required to metabolize the toxin inhibitor metabolic precursors.
    Type: Application
    Filed: November 1, 2005
    Publication date: September 28, 2006
    Applicants: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Milan Blake, John Bogdan, Javier Nazario-Larrieu
  • Method for the production of bacterial toxins
    Publication number: 20060204955
    Abstract: Methods and compositions are provided for the enhanced production of bacterial toxins in large-scale cultures. Specifically, methods and compositions for reducing bacterial toxin expression inhibitors are providing including, but not limited to, addition of toxin expression inhibitor binding compounds, culture media having reduced concentrations of toxin inhibitor metabolic precursors and genetically modified toxogenic bacteria lacking enzymes required to metabolize the toxin inhibitor metabolic precursors.
    Type: Application
    Filed: November 29, 2005
    Publication date: September 14, 2006
    Applicants: Baxter Healthcare S.A, Baxter International Inc.
    Inventors: Milan Blake, John Bogdan, Javier Nazario-Larrieu
  • Method for the production of bacterial toxins
    Patent number: 7045314
    Abstract: Methods and compositions are provided for the enhanced production of bacterial toxins in large-scale cultures. Specifically, methods and compositions for reducing bacterial toxin expression inhibitors are providing including, but not limited to, addition of toxin expression inhibitor binding compounds, culture media having reduced concentrations of toxin inhibitor metabolic precursors and genetically modified toxogenic bacteria lacking enzymes required to metabolize the toxin inhibitor metabolic precursors.
    Type: Grant
    Filed: April 4, 2001
    Date of Patent: May 16, 2006
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Milan S. Blake, John A. Bogdan, Jr., Javier Nazario-Larrieu
  • Method for the production of bacterial toxins
    Patent number: 7018813
    Abstract: Methods and compositions are provided for the enhanced production of bacterial toxins in large-scale cultures. Specifically, methods and compositions for reducing bacterial toxin expression inhibitors are providing including, but not limited to, addition of toxin expression inhibitor binding compounds, culture media having reduced concentrations of toxin inhibitor metabolic precursors and genetically modified toxogenic bacteria lacking enzymes required to metabolize the toxin inhibitor metabolic precursors.
    Type: Grant
    Filed: October 3, 2003
    Date of Patent: March 28, 2006
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Milan S. Blake, John A. Bogdan, Jr., Javier Nazario-Larrieu
  • Method for the production of bacterial toxins
    Publication number: 20050100553
    Abstract: Methods and compositions are provided for the enhanced production of bacterial toxins in large-scale cultures. Specifically, methods and compositions for reducing bacterial toxin expression inhibitors are providing including, but not limited to, addition of toxin expression inhibitor binding compounds, culture media having reduced concentrations of toxin inhibitor metabolic precursors and genetically modified toxogenic bacteria lacking enzymes required to metabolize the toxin inhibitor metabolic precursors.
    Type: Application
    Filed: October 3, 2003
    Publication date: May 12, 2005
    Applicant: Baxter Healthcare S.A.
    Inventors: Milan Blake, John Bogdan, Javier Nazario-Larrieu
  • Method for the production of bacterial toxins
    Patent number: 6686180
    Abstract: Methods and compositions are provided for the enhanced production of bacterial toxins in large-scale cultures. Specifically, methods and compositions for reducing bacterial toxin expression inhibitors are providing including, but not limited to, addition of toxin expression inhibitor binding compounds, culture media having reduced concentrations of toxin inhibitor metabolic precursors and genetically modified toxogenic bacteria lacking enzymes required to metabolize the toxin inhibitor metabolic precursors.
    Type: Grant
    Filed: April 4, 2001
    Date of Patent: February 3, 2004
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Milan S. Blake, John A. Bogdan, Jr., Javier Nazario-Larrieu
  • Method for the production of bacterial toxins
    Publication number: 20020165344
    Abstract: Methods and compositions are provided for the enhanced production of bacterial toxins in large-scale cultures. Specifically, methods and compositions for reducing bacterial toxin expression inhibitors are providing including, but not limited to, addition of toxin expression inhibitor binding compounds, culture media having reduced concentrations of toxin inhibitor metabolic precursors and genetically modified toxogenic bacteria lacking enzymes required to metabolize the toxin inhibitor metabolic precursors.
    Type: Application
    Filed: April 4, 2001
    Publication date: November 7, 2002
    Inventors: Milan S. Blake, John A. Bogdan, Javier Nazario-Larrieu
  • Method for the production of bacterial toxins
    Publication number: 20020061555
    Abstract: Methods and compositions are provided for the enhanced production of bacterial toxins in large-scale cultures. Specifically, methods and compositions for reducing bacterial toxin expression inhibitors are providing including, but not limited to, addition of toxin expression inhibitor binding compounds, culture media having reduced concentrations of toxin inhibitor metabolic precursors and genetically modified toxogenic bacteria lacking enzymes required to metabolize the toxin inhibitor metabolic precursors.
    Type: Application
    Filed: April 4, 2001
    Publication date: May 23, 2002
    Inventors: Milan S. Blake, John A. Bogdan, Javier Nazario-Larrieu