Patents by Inventor Javier Ochoa-Repáraz

Javier Ochoa-Repáraz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BACTERIA PRODUCING GAMMA-AMINOBUTYRIC ACID (GABA) AND USES OF THE BACTERIA
    Publication number: 20240424035
    Abstract: Probiotic bacteria are genetically modified to produce and excrete enhanced levels of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Exemplary probiotic bacteria include Lactococcus lactis (L. lactis). The genetically modified probiotic bacteria can be prepared as an aqueous suspension and/or incorporated into food and nutraceuticals for oral administration to a subject. An oral formulation including the genetically modified probiotic bacteria can be used to treat inflammatory diseases and/or behavioral disorders caused by or associated with GABA-GABA signaling deficiency or by excess of excitatory neurotransmitters (such as glutamate). Inflammatory conditions that can be treated with the genetically modified probiotic bacteria include multiple sclerosis (MS) and irritable bowel disease (IBD).
    Type: Application
    Filed: January 26, 2022
    Publication date: December 26, 2024
    Applicants: Washington State University, Eastern Washington University
    Inventors: Jean-Baptiste O. Roullet, Javier Ochoa-Reparaz, Kenneth Michael Gibson, Andrea Castillo
  • Nutraceutical Composition And Methods For Prevention Or Treating Multiple Sclerosis
    Publication number: 20160158269
    Abstract: The present invention embraces nutraceutical compositions containing isolated Bacteroides fragilis capsular polysaccharide A for use in methods of preventing or treating multiple sclerosis.
    Type: Application
    Filed: February 23, 2016
    Publication date: June 9, 2016
    Inventors: Lloyd H. Kasper, Javier Ochoa-Reparaz
  • NUTRACEUTICAL COMPOSITION AND METHODS FOR PREVENTING OR TREATING MULTIPLE SCLEROSIS
    Publication number: 20160143941
    Abstract: The present invention embraces nutraceutical compositions containing isolated Bacteroides fragilis capsular polysaccharide A for use in methods of preventing or treating multiple sclerosis.
    Type: Application
    Filed: December 14, 2015
    Publication date: May 26, 2016
    Applicant: Trustees of Dartmouth College
    Inventors: Lloyd H. Kasper, Javier Ochoa-Reparaz
  • METHOD FOR STIMULATING FOXP3+ REGULATORY T CELL EXPRESSION OF CD39
    Publication number: 20140030807
    Abstract: Disclosed is the use of isolated Bacteroides fragilis capsular polysaccharide A in a method for stimulating FoxP3+ regulatory T cell expression of CD39.
    Type: Application
    Filed: July 19, 2011
    Publication date: January 30, 2014
    Applicant: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Lloyd H. Kasper, Javier Ochoa-Reparaz
  • Prevention or treatment of immune-relevant disease by modification of microfloral populations
    Patent number: 8586029
    Abstract: The present invention is a method for preventing or treating an immune-relevant disease by modulating commensal microbiota populations via antibiotics, exogenous microbiota and/or probiotics.
    Type: Grant
    Filed: June 3, 2009
    Date of Patent: November 19, 2013
    Assignee: Trustees of Dartmouth College
    Inventors: Lloyd H. Kasper, Javier Ochoa-Repáraz
  • Nutraceutical composition and methods for preventing or treating multiple sclerosis
    Patent number: 8580278
    Abstract: The present invention embraces nutraceutical compositions containing isolated Bacteroides fragilis capsular polysaccharide A for use in methods of preventing or treating multiple sclerosis.
    Type: Grant
    Filed: June 17, 2011
    Date of Patent: November 12, 2013
    Assignee: Trustees of Dartmouth College
    Inventors: Lloyd H. Kasper, Javier Ochoa-Reparaz
  • Nutraceutical Composition and Methods for Preventing or Treating Multiple Sclerosis
    Publication number: 20120094950
    Abstract: The present invention embraces nutraceutical compositions containing isolated Bacteroides fragilis capsular polysaccharide A for use in methods of preventing or treating multiple sclerosis.
    Type: Application
    Filed: June 17, 2011
    Publication date: April 19, 2012
    Applicant: Trustees of Dartmouth College
    Inventors: Lloyd H. Kasper, Javier Ochoa-Reparaz
  • Prevention or Treatment of Immune-Relevant Disease by Modification of Microfloral Populations
    Publication number: 20110086011
    Abstract: The present invention is a method for preventing or treating an immune-relevant disease by modulating commensal microbiota populations via antibiotics, exogenous microbiota and/or probiotics.
    Type: Application
    Filed: June 3, 2009
    Publication date: April 14, 2011
    Inventors: Lloyd H. Kasper, Javier Ochoa-Repáraz
  • Nutraceutical Composition and Methods for Preventing or Treating Multiple Sclerosis
    Publication number: 20110009360
    Abstract: The present invention embraces nutraceutical compositions containing isolated Bacteroides fragilis capsular polysaccharide A for use in methods of preventing or treating multiple sclerosis.
    Type: Application
    Filed: July 20, 2010
    Publication date: January 13, 2011
    Inventors: Lloyd H. Kasper, Javier Ochoa-Reparaz
  • Nutraceutical composition and methods for preventing or treating multiple sclerosis
    Publication number: 20100311686
    Abstract: The present invention embraces nutraceutical compositions containing isolated Bacteroides fragilis capsular polysaccharide A for use in methods of preventing or treating multiple sclerosis.
    Type: Application
    Filed: November 3, 2009
    Publication date: December 9, 2010
    Inventors: Lloyd H. Kasper, Javier Ochoa-Reparaz