Patents by Inventor Javier R. Revollo

Javier R. Revollo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NAD biosynthesis systems
    Patent number: 8268575
    Abstract: The present invention generally relates to a nicotinamide adenine dinucleotide (NAD) biosynthesis system and methods of screening for NAD biosynthesis effectors. Among the various aspects of the present invention is the provision of an in vitro-reconstituted mammalian NAD biosynthesis system that can be used for the high-throughput screening of chemical activators and inhibitors for mammalian NAD biosynthesis. Another aspect of the invention provides a method of identifying a compound that effects in vivo activity of NAD metabolic enzymes. Further aspects of the invention include nucleic acid sequences, vectors, and transformed cells that can be used in the methods described herein.
    Type: Grant
    Filed: September 20, 2005
    Date of Patent: September 18, 2012
    Assignee: Washington University
    Inventors: Shin-Ichiro Imai, Javier R. Revollo, Andrew A. Grimm
  • Processes for regulating blood glucose in a mammal
    Patent number: 7737158
    Abstract: The present invention relates to processes for regulating the blood glucose concentration of a mammal.
    Type: Grant
    Filed: October 3, 2006
    Date of Patent: June 15, 2010
    Assignee: Washington University
    Inventors: Shin-ichiro Imai, Javier R. Revollo
  • NAD BIOSYNTHESIS SYSTEMS
    Publication number: 20090246803
    Abstract: The present invention generally relates to a nicotinamide adenine dinucleotide (NAD) biosynthesis system and methods of screening for NAD biosynthesis effectors. Among the various aspects of the present invention is the provision of an in vitro-reconstituted mammalian NAD biosynthesis system that can be used for the high-throughput screening of chemical activators and inhibitors for mammalian NAD biosynthesis. Another aspect of the invention provides a method of identifying a compound that effects in vivo activity of NAD metabolic enzymes. Further aspects of the invention include nucleic acid sequences, vectors, and transformed cells that can be used in the methods described herein.
    Type: Application
    Filed: September 20, 2005
    Publication date: October 1, 2009
    Applicant: WASHINGTON UNIVERSITY
    Inventors: Shin-Ichiro Imai, Javier R. Revollo, Andrew A. Grimm