Abstract: Disclosed herein are methods for personalized treatment of individual patient tumors. A computer software configured to integrate with a radiation therapy treatment planning system is presented. The computer software is configured to: assign a radiation sensitivity index (RSI) of a subject's tumor based at least in part on expression levels of one or more signature genes in the tumor; calculate a recommended personalized radiation dosage (RxRSI) for the subject based at least in part on a pre-determined genomic adjusted radiation dose (GARD) value and the RSI; and provide, to the radiation therapy treatment planning system, the recommended RxRSI as a radiation therapy dose for a radiation plan.

Abstract: A dynamic tagging system facilitates the control, monitoring, and operation of technical components, such as virtual machines, in cloud environments. The dynamic tagging system performs an analysis on unstructured metadata tags linked to the technical components. The unstructured metadata tags may be created for technical components by authorized operators of the technical components, for instance. The dynamic tagging system may analyze an individual unstructured metadata tag or a combination of unstructured metadata tags assigned to a technical component to automatically trigger any pre-configured control, monitoring or operational actions for the technical component. As one example, the dynamic tagging system detects a trigger condition for an action trigger to perform automated electronic communications between any selected entities to convey information about the technical component.

Abstract: The present invention provides a composition comprising one or more deoxyribonucleosides for use in the treatment of a mitochondrial DNA depletion and/or multiple deletions syndrome provided that the syndrome is not caused by a defect in the deoxyribonucleoside triphosphate (dNTP) metabolism. With the use of the invention there is a recovery in mitochondrial DNA levels independently from the severity of the patient's disease, which confers a great therapeutic value to the invention.

Abstract: Aspects of the subject technology provide miniaturization and improved power dissipation for communication systems that include a radio frequency power amplifier. In aspects, a radio frequency power amplifier may be mounted inside a cavity in a primary printed circuit board. Circuits related the power amplifier, such as output matching circuits, biasing circuits, and/or passive components, may be mounted on submodule printed circuit board that itself is mounted to the primary printed circuit board in a stacked configuration above the power amplifier and the cavity containing the power amplifier.

Abstract: Systems and methods for personalized dose and fractionation for radiation therapy are described herein. An example method can include predicting a patient-specific radiosensitivity parameter alpha (?) value for a tumor, where the patient-specific radiosensitivity parameter alpha (?) value is predicted based on a first set of signature genes. The method can also include predicting a patient-specific radiosensitivity parameter beta (?) value for the tumor, where the patient-specific radiosensitivity parameter beta (?) value is predicted based on a second set of signature genes. The method can further include calculating a patient-specific dose and fractionation using a radiation cytotoxicity score (RCS) function and the patient-specific radiosensitivity parameters alpha (?) and beta (?) values. RCS is predictive of clinical outcome.

Abstract: An apparatus for toning and strengthening the muscles of the neck, chin and face that is supported on one or more of the user's shoulders during use of the apparatus. The apparatus has a frame with frame members that define a shoulder supporting section configured to position an elastomeric sheet adjacent the user's head during use of the apparatus. The frame members also define a sheet support section that holds the elastomeric sheet on the frame. A positioning guide associated with the frame helps position the apparatus on the user. An adjusting mechanism allows the user to rotate the elastomeric sheet to increase or decrease its tension to increase or decrease the resistance from the user pressing his or her head against the elastomeric sheet. A locking mechanism prevents unwanted rotation of the elastomeric sheet. Clamps or other mechanisms removably attach the elastomeric sheet to the frame.

Abstract: Disclosed herein are methods for personalized treatment of individual patient tumors. A computer software configured to integrate with a radiation therapy treatment planning system is presented. The computer software is configured to: assign a radiation sensitivity index (RSI) of a subject's tumor based at least in part on expression levels of one or more signature genes in the tumor; calculate a recommended personalized radiation dosage (RxRSI) for the subject based at least in part on a pre-determined genomic adjusted radiation dose (GARD) value and the RSI; and provide, to the radiation therapy treatment planning system, the recommended RxRSI as a radiation therapy dose for a radiation plan.

Abstract: Disclosed herein are methods for personalized treatment of individual patient tumors. In one embodiment, a method of calculating a personalized radiation therapy dosage for a subject comprises determining expression levels of one or more signature genes from a subject's tumor sample, applying a linear regression model to the gene expression levels and assigning a radiation sensitivity index (RSI) to the subject's tumor sample, calculating a genomic adjusted radiation dose (GARD) value based on RSI, radiation dose and fractionation schedule of the subject, and calculating a personalized radiation dosage (RxRSI) for the subject based on a pre-determined GARD value.

Abstract: The present invention provides a composition comprising one or more deoxyribonucleosides for use in the treatment of a mitochondrial DNA depletion and/or multiple deletions syndrome provided that the syndrome is not caused by a defect in the deoxyribonucleoside triphosphate (dNTP) metabolism. With the use of the invention there is a recovery in mitochondrial DNA levels independently from the severity of the patient's disease, which confers a great therapeutic value to the invention.

Abstract: Utilizing a computing device executing a master chatbot and one or more modular chatbots to respond to one or more chat messages. A computing device executing the master chatbot receives one or more chat messages. The computing device parses the received one or more chat messages to discover an intent and entities contained within the chat messages. A ranking algorithm is employed to rank the master chatbot and a plurality of modular chatbots, the ranking algorithm scoring the master chatbot and the plurality of modular chatbots based upon the intent and entities contained within the one or more chat messages. The master chatbot responds to the chat message if the ranking algorithm rates the master chatbot highest or forwards automatically the one or more chat messages to a ranked modular chatbot for response if the ranking algorithm rates the ranked modular chatbot highest.

Abstract: A multi-layer resource control stack based system may generate an availability indication for multiple domains supported by the resource control stack and send the indication to a client node. The client node may respond with a selection of a domain. The client node may also indicate a compute resource to be managed by the resource control stack. In response to the selection from the client node, the resource control stack may initiate a virtual representation of the domain. The client node may interact with the virtual representation to receive recommendations, utilization data, and control information relevant to the compute resource and within a subject area associated with the domain.

Abstract: A dynamic tagging system facilitates the control, monitoring, and operation of technical components, such as virtual machines, in cloud environments. The dynamic tagging system performs an analysis on unstructured metadata tags linked to the technical components. The unstructured metadata tags may be created for technical components by authorized operators of the technical components, for instance. The dynamic tagging system may analyze an individual unstructured metadata tag or a combination of unstructured metadata tags assigned to a technical component to automatically trigger any pre-configured control, monitoring or operational actions for the technical component. As one example, the dynamic tagging system detects a trigger condition for an action trigger to perform automated electronic communications between any selected entities to convey information about the technical component.

Abstract: Utilizing a computing device executing a master chatbot and one or more modular chatbots to respond to one or more chat messages. A computing device executing the master chatbot receives one or more chat messages. The computing device parses the received one or more chat messages to discover an intent and entities contained within the chat messages. A ranking algorithm is employed to rank the master chatbot and a plurality of modular chatbots, the ranking algorithm scoring the master chatbot and the plurality of modular chatbots based upon the intent and entities contained within the one or more chat messages. The master chatbot responds to the chat message if the ranking algorithm rates the master chatbot highest or forwards automatically the one or more chat messages to a ranked modular chatbot for response if the ranking algorithm rates the ranked modular chatbot highest.

Abstract: A dynamic tagging system facilitates the control, monitoring, and operation of technical components, such as virtual machines, in cloud environments. The dynamic tagging system performs an analysis on unstructured metadata tags linked to the technical components. The unstructured metadata tags may be created for technical components by authorized operators of the technical components, for instance. The dynamic tagging system may analyze an individual unstructured metadata tag or a combination of unstructured metadata tags assigned to a technical component to automatically trigger any pre-configured control, monitoring or operational actions for the technical component. As one example, the dynamic tagging system detects a trigger condition for an action trigger to perform automated electronic communications between any selected entities to convey information about the technical component.

Abstract: Utilizing a computing device executing a master chatbot and one or more modular chatbots to respond to one or more chat messages. A computing device executing the master chatbot receives one or more chat messages. The computing device parses the received one or more chat messages to discover an intent and entities contained within the chat messages. A ranking algorithm is employed to rank the master chatbot and a plurality of modular chatbots, the ranking algorithm scoring the master chatbot and the plurality of modular chatbots based upon the intent and entities contained within the one or more chat messages. The master chatbot responds to the chat message if the ranking algorithm rates the master chatbot highest or forwards automatically the one or more chat messages to a ranked modular chatbot for response if the ranking algorithm rates the ranked modular chatbot highest.

Abstract: A multi-layer resource control stack based system may generate an availability indication for multiple domains supported by the resource control stack and send the indication to a client node. The client node may respond with a selection of a domain. The client node may also indicate a compute resource to be managed by the resource control stack. In response to the selection from the client node, the resource control stack may initiate a virtual representation of the domain. The client node may interact with the virtual representation to receive recommendations, utilization data, and control information relevant to the compute resource and within a subject area associated with the domain.

Abstract: Disclosed herein are methods for personalized treatment of individual patient tumors. In one embodiment, a method of calculating a personalized radiation therapy dosage for a subject comprises determining expression levels of one or more signature genes from a subject's tumor sample, applying a linear regression model to the gene expression levels and assigning a radiation sensitivity index (RSI) to the subject's tumor sample, calculating a genomic adjusted radiation dose (GARD) value based on RSI, radiation dose and fractionation schedule of the subject, and calculating a personalized radiation dosage (RxRSI) for the subject based on a pre-determined GARD value.

Abstract: A multi-layer resource control stack based system may generate an availability indication for multiple domains supported by the resource control stack and send the indication to a client node. The client node may respond with a selection of a domain. The client node may also indicate a compute resource to be managed by the resource control stack. In response to the selection from the client node, the resource control stack may initiate a virtual representation of the domain. The client node may interact with the virtual representation to receive recommendations, utilization data, and control information relevant to the compute resource and within a subject area associated with the domain.

Abstract: A multi-layer resource control stack based system may generate an availability indication for multiple domains supported by the resource control stack and send the indication to a client node. The client node may respond with a selection of a domain. The client node may also indicate a compute resource to be managed by the resource control stack. In response to the selection from the client node, the resource control stack may initiate a virtual representation of the domain. The client node may interact with the virtual representation to receive recommendations, utilization data, and control information relevant to the compute resource and within a subject area associated with the domain.

Abstract: Utilizing a computing device executing a master chatbot and one or more modular chatbots to respond to one or more chat messages. A computing device executing the master chatbot receives one or more chat messages. The computing device parses the received one or more chat messages to discover an intent and entities contained within the chat messages. A ranking algorithm is employed to rank the master chatbot and a plurality of modular chatbots, the ranking algorithm scoring the master chatbot and the plurality of modular chatbots based upon the intent and entities contained within the one or more chat messages. The master chatbot responds to the chat message if the ranking algorithm rates the master chatbot highest or forwards automatically the one or more chat messages to a ranked modular chatbot for response if the ranking algorithm rates the ranked modular chatbot highest.